Difference between revisions of "Team:DTU-Denmark"
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<!-- Collect the nav links, forms, and other content for toggling --> | <!-- Collect the nav links, forms, and other content for toggling --> | ||
<div class="collapse navbar-collapse" id="nav-collapse"> | <div class="collapse navbar-collapse" id="nav-collapse"> | ||
<ul class="nav navbar-nav"> | <ul class="nav navbar-nav"> | ||
| − | + | <li class="active"> | |
| − | + | <a href="/Team:DTU-Denmark" | |
| − | + | >Home | |
| − | + | </a></li> | |
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| − | + | > | |
| − | + | <a href="" | |
| − | + | class="dropdown-toggle" | |
| − | + | data-toggle="dropdown" | |
| − | + | role="button" | |
| − | + | aria-expanded="false">Team and Attributions | |
| − | + | <span class="caret"></span></a><ul class="dropdown-menu" role="menu"> | |
| − | + | <li > | |
| − | + | <a href="/Team:DTU-Denmark/Team" | |
| − | + | >Team | |
| − | + | </a></li> | |
| − | + | <li > | |
| − | + | <a href="/Team:DTU-Denmark/Attributions" | |
| − | + | >Attributions | |
| − | + | </a></li></ul></li> | |
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| + | aria-expanded="false">Project | ||
| + | <span class="caret"></span></a><ul class="dropdown-menu" role="menu"> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Project/Overview" | ||
| + | >Overview | ||
| + | </a></li> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Project/Background" | ||
| + | >Background | ||
| + | </a></li> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Project/MAGE" | ||
| + | >MAGE subtilis | ||
| + | </a></li> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Project/Tyrocidine" | ||
| + | >Tyrocidine | ||
| + | </a></li> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Project/Chip" | ||
| + | >Lab-on-a-disc | ||
| + | </a></li> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Project/Inteins" | ||
| + | >Inteins | ||
| + | </a></li> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Project/Detection" | ||
| + | >Detection of NRP | ||
| + | </a></li></ul></li> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Practices" | ||
| + | >Human Practices | ||
| + | </a></li> | ||
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| + | > | ||
| + | <a href="" | ||
| + | class="dropdown-toggle" | ||
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| + | aria-expanded="false">Parts Collection | ||
| + | <span class="caret"></span></a><ul class="dropdown-menu" role="menu"> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Parts" | ||
| + | >Parts | ||
| + | </a></li> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Description" | ||
| + | >Characterisation of xylR | ||
| + | </a></li></ul></li> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Journal" | ||
| + | >Journal | ||
| + | </a></li> | ||
| + | <li > | ||
| + | <a href="/Team:DTU-Denmark/Software" | ||
| + | >Software | ||
| + | </a></li> | ||
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| − | + | <li > | |
| − | + | <a href="/Team:DTU-Denmark/Achievements" | |
| − | + | >Key Achievements | |
| − | + | </a></li> | |
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| − | + | <a href="/Team:DTU-Denmark/Collaborations" | |
| − | + | >Collaborations | |
| − | + | </a></li> | |
| − | + | <li > | |
| − | + | <a href="/Team:DTU-Denmark/Judging_Form" | |
| + | >Judging Form | ||
| + | </a></li></ul></li> | ||
<li class="hidden-xs"> | <li class="hidden-xs"> | ||
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| − | + | <li><a class="page-scroll" href="#ProjectDescription">Project Description</a></li><li><a class="page-scroll" href="#SocialMedia">Social Media</a></li> | |
| − | + | </ul> | |
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| − | + | <h3>Technical University of Denmark</h3> | |
| − | + | <h1>The Synthesizer</h1> | |
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<hr/> | <hr/> | ||
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<ul class="list-inline hidden-xs hidden-sm"> | <ul class="list-inline hidden-xs hidden-sm"> | ||
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Scroll down for more<br> | Scroll down for more<br> | ||
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<i class="fa fa-angle-double-down"></i> | <i class="fa fa-angle-double-down"></i> | ||
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| − | <div id=" | + | |
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| − | Project | + | Project Description |
</h1> | </h1> | ||
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| + | <p style="text-align: center;"><span style="font-size:72px;"><span style="font-size:72px;"><span class="fa fa-headphones" style="color:rgb(0, 0, 0);"></span></span></span></p> | ||
| − | <p style="text-align: center;"> | + | <p style="text-align: center;">Listen to our podcast about our <a href="https://static.igem.org/mediawiki/2015/5/50/Podcast_project.mp4"><em>Project</em></a> or <a href="https://static.igem.org/mediawiki/2015/f/f5/Podcast_education.mp4"><em>Human practises</em></a></p> |
| − | <p> | + | <p> </p> |
| + | |||
| + | <p><img alt="" src="https://static.igem.org/mediawiki/2015/5/5e/DTU-Denmark_gold.png" style="float:left; margin-right:10px;" /></p> | ||
| + | |||
| + | <p><br /> | ||
| + | DTU Denmark received a gold medal at the Giant Jamboree in Boston 2015 and a nomination for best educational human practises. Click on the headphones to hear our podcasts explaining our project and our human practises.</p> | ||
| + | |||
| + | <p>We also designed a <a href="https://2015.igem.org/Team:DTU-Denmark/Software">Wiki Wizard</a> that allows you to easily create and design wikis without knowing about HTML, CSS, and JavaScript. By using the shared editing mode, team members can edit the Wiki at the same time - just like Google Docs.</p> | ||
<p> </p> | <p> </p> | ||
| + | <p>Nonribosomal peptides have important anti-bacterial, anti-cancer, and immunosuppressive biological activities. They are synthesized by modular, high molecular weight enzymes that assemble more than 500 different amino acid substrates in an assembly line manner. For this reason, synthetic biologists have tried to engineer these proteins and to switch modules to create analogs and novel natural products, but with little success. Despite being modular, the interactions between modules have evolved to be highly specific, making synthetic Non-Ribosomal Peptide Synthases (NRPS) a challenge to engineer. Instead of switching modules we introduced a recombination system targeting oligo integration in Bacillus subtilis. We used the recombineering system to alter the active sites determining substrate specificity, thereby creating variants of antibiotics. Our focus was the tyrocidine antibiotic, which cannot be used intravenously due to its toxicity. Our goal is to create new analogs through multiplex automated genome engineering to reduce toxicity.</p> | ||
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| + | <p style="text-align: center;"><img alt="" src="https://static.igem.org/mediawiki/2015/7/7d/DTU-Denmark_drawingpng.png" style="width: 625px; height: 378px;" /></p> | ||
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| + | <p> </p> | ||
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| − | <div id=" | + | <div id="SocialMedia"> |
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<div class="row col-md-12"> | <div class="row col-md-12"> | ||
<h1> | <h1> | ||
Social Media | Social Media | ||
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| + | <div class="col-md-6"> | ||
<p><a class="twitter-timeline" data-widget-id="631150747221139456" href="https://twitter.com/iGEM_DTU">Tweets by @iGEM_DTU</a> <script>!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?'http':'https';if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+"://platform.twitter.com/widgets.js";fjs.parentNode.insertBefore(js,fjs);}}(document,"script","twitter-wjs");</script></p> | <p><a class="twitter-timeline" data-widget-id="631150747221139456" href="https://twitter.com/iGEM_DTU">Tweets by @iGEM_DTU</a> <script>!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?'http':'https';if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+"://platform.twitter.com/widgets.js";fjs.parentNode.insertBefore(js,fjs);}}(document,"script","twitter-wjs");</script></p> | ||
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<div class="col-md-6"> | <div class="col-md-6"> | ||
<div class="fb-page" data-adapt-container-width="true" data-height="600" data-hide-cover="false" data-href="https://www.facebook.com/dtubiobuilders" data-show-facepile="true" data-show-posts="true" data-small-header="false"> | <div class="fb-page" data-adapt-container-width="true" data-height="600" data-hide-cover="false" data-href="https://www.facebook.com/dtubiobuilders" data-show-facepile="true" data-show-posts="true" data-small-header="false"> | ||
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Latest revision as of 23:51, 20 November 2015
Project Description
Listen to our podcast about our Project or Human practises
DTU Denmark received a gold medal at the Giant Jamboree in Boston 2015 and a nomination for best educational human practises. Click on the headphones to hear our podcasts explaining our project and our human practises.
We also designed a Wiki Wizard that allows you to easily create and design wikis without knowing about HTML, CSS, and JavaScript. By using the shared editing mode, team members can edit the Wiki at the same time - just like Google Docs.
Nonribosomal peptides have important anti-bacterial, anti-cancer, and immunosuppressive biological activities. They are synthesized by modular, high molecular weight enzymes that assemble more than 500 different amino acid substrates in an assembly line manner. For this reason, synthetic biologists have tried to engineer these proteins and to switch modules to create analogs and novel natural products, but with little success. Despite being modular, the interactions between modules have evolved to be highly specific, making synthetic Non-Ribosomal Peptide Synthases (NRPS) a challenge to engineer. Instead of switching modules we introduced a recombination system targeting oligo integration in Bacillus subtilis. We used the recombineering system to alter the active sites determining substrate specificity, thereby creating variants of antibiotics. Our focus was the tyrocidine antibiotic, which cannot be used intravenously due to its toxicity. Our goal is to create new analogs through multiplex automated genome engineering to reduce toxicity.
