Difference between revisions of "Team:DTU-Denmark"

 
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{{Team:DTU-Denmark/header}}
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<html>
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<nav class="navbar navbar-default navbar-fixed-top" role="navigation">
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  <head>
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  <!-- Brand and toggle get grouped for better mobile display -->
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    <meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1, user-scalable=no">
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  <div class="container-fluid">
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    <meta http-equiv="X-UA-Compatible" content="IE=edge">
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    <div class="navbar-header">
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      <button type="button" class="navbar-toggle" data-toggle="collapse" data-target="#nav-collapse">
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      <link rel=stylesheet href="/Team:DTU-Denmark/loadphpcss?action=raw&ctype=text/css">
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        <span class="sr-only">Toggle navigation</span>
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      <link rel=stylesheet href="/Team:DTU-Denmark/bootstrapcss?action=raw&ctype=text/css">
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        <i class="fa fa-bars"></i>
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      <link rel=stylesheet href="/Team:DTU-Denmark/font-awesomecss?action=raw&ctype=text/css">
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      </button>
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      <link rel=stylesheet href="/Team:DTU-Denmark/wikicss?action=raw&ctype=text/css">
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      <a class="navbar-brand navimg" href="#"><img src="/_themes/dtu/images/dtulogo.png"></a>
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      <link rel=stylesheet href="/Team:DTU-Denmark/timelinecss?action=raw&ctype=text/css">
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    </div>
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      <link rel=stylesheet href="/Team:DTU-Denmark/menufixcss?action=raw&ctype=text/css">
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    <!-- Collect the nav links, forms, and other content for toggling -->
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    <div class="collapse navbar-collapse" id="nav-collapse">
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    <script type="text/javascript" src="/Team:DTU-Denmark/jqueryjs?action=raw&ctype=text/javascript"></script>
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      <ul class="nav navbar-nav">
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    <script type="text/javascript" src="/Team:DTU-Denmark/bootstrapjs?action=raw&ctype=text/javascript"></script>
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            <li id="Home">
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    <script type="text/javascript" src="/Team:DTU-Denmark/jqueryeasingjs?action=raw&ctype=text/javascript"></script>
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            <a href="/Team:DTU-Denmark"
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    <script type="text/javascript" src="/Team:DTU-Denmark/wikijs?action=raw&ctype=text/javascript"></script>
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              >Home
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              </a></li>
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    <!-- MathJax (LaTeX for the web) -->
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            <li id="Team">
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    <script src="https://2015.igem.org/common/MathJax-2.5-latest/MathJax.js?config=TeX-AMS-MML_SVG"></script>
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            <a href="/Team:DTU-Denmark/Team"
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              >Team
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  </head>
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              </a></li>
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  <body data-spy="scroll" data-target="#scrollspy" data-offset="90">
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            <li>
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    <div id="fb-root"></div>
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            <a href=""
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    <script>(function(d, s, id) {
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              class="dropdown-toggle"
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      var js, fjs = d.getElementsByTagName(s)[0];
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              data-toggle="dropdown"
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      if (d.getElementById(id)) return;
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              role="button"
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      js = d.createElement(s); js.id = id;
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              aria-expanded="false">Project
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      js.src = "//connect.facebook.net/da_DK/all.js#xfbml=1&version=v2.4";
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              <span class="caret"></span></a><ul class="dropdown-menu" role="menu">
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      fjs.parentNode.insertBefore(js, fjs);
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            <li id="Description">
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    }(document, 'script', 'facebook-jssdk'));</script>
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            <a href="/Team:DTU-Denmark/Description"
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    <nav class="navbar navbar-default navbar-fixed-top" role="navigation">
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              >Description
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      <!-- Brand and toggle get grouped for better mobile display -->
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              </a></li>
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      <div class="container-fluid">
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            <li id="ExperimentsProtocols">
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        <div class="navbar-header">
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            <a href="/Team:DTU-Denmark/Experiments"
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          <button type="button" class="navbar-toggle" data-toggle="collapse" data-target="#nav-collapse">
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              >Experiments &amp; Protocols
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            <span class="sr-only">Toggle navigation</span>
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              </a></li>
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            <i class="fa fa-bars"></i>
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            <li id="Results">
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          </button>
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            <a href="/Team:DTU-Denmark/Results"
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          <a class="navbar-brand navimg" href="#"><img src="https://static.igem.org/mediawiki/2015/b/b7/DTU-Denmark_dtulogo.png"></a>
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              >Results
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        </div>
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              </a></li>
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        <!-- Collect the nav links, forms, and other content for toggling -->
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            <li id="Design">
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        <div class="collapse navbar-collapse" id="nav-collapse">
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            <a href="/Team:DTU-Denmark/Design"
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          <ul class="nav navbar-nav">
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              >Design
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                <li class="active">
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              </a></li></ul></li>
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                <a href="/Team:DTU-Denmark"
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            <li>
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                  >Home
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            <a href=""
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                  </a></li>
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              class="dropdown-toggle"
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                <li  
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              data-toggle="dropdown"
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              role="button"
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              aria-expanded="false">Parts
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              <span class="caret"></span></a><ul class="dropdown-menu" role="menu">
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            <li id="TeamParts">
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            <a href="/Team:DTU-Denmark/Parts"
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                >
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              >Team Parts
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                <a href=""
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              </a></li>
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                  class="dropdown-toggle"
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            <li id="BasicParts">
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                  data-toggle="dropdown"
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            <a href="/Team:DTU-Denmark/Basic_Part"
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                  role="button"
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              >Basic Parts
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                  aria-expanded="false">Team and Attributions
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              </a></li>
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                  <span class="caret"></span></a><ul class="dropdown-menu" role="menu">
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            <li id="CompositeParts">
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                <li >
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            <a href="/Team:DTU-Denmark/Composite_Part"
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                <a href="/Team:DTU-Denmark/Team"
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              >Composite Parts
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                  >Team
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              </a></li>
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                  </a></li>
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            <li id="PartCollection">
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                <li >
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            <a href="/Team:DTU-Denmark/Part_Collection"
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                <a href="/Team:DTU-Denmark/Attributions"
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              >Part Collection
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                  >Attributions
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              </a></li></ul></li>
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                  </a></li></ul></li>
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            <li id="Notebook">
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                <li  
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            <a href="/Team:DTU-Denmark/Notebook"
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              >Notebook
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              </a></li>
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            <li id="Attributions">
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            <a href="/Team:DTU-Denmark/Attributions"
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              >Attributions
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              </a></li>
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            <li id="Collaborations">
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            <a href="/Team:DTU-Denmark/Collaborations"
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              >Collaborations
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              </a></li>
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−
            <li id="HumanPractices">
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            <a href="/Team:DTU-Denmark/Practices"
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              >Human Practices
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              </a></li>
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−
            <li id="Safety">
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                >
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            <a href="/Team:DTU-Denmark/Safety"
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                <a href=""
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              >Safety
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                  class="dropdown-toggle"
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              </a></li>
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                  data-toggle="dropdown"
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            <li id="Modeling">
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                  role="button"
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            <a href="/Team:DTU-Denmark/Modeling"
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                  aria-expanded="false">Project
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              >Modeling
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                  <span class="caret"></span></a><ul class="dropdown-menu" role="menu">
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              </a></li>
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                <li >
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            <li id="Measurement">
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                <a href="/Team:DTU-Denmark/Project/Overview"
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            <a href="/Team:DTU-Denmark/Measurement"
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                  >Overview
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              >Measurement
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                  </a></li>
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              </a></li>
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                <li >
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            <li id="Software">
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                <a href="/Team:DTU-Denmark/Project/Background"
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            <a href="/Team:DTU-Denmark/Software"
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                  >Background
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              >Software
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                  </a></li>
−
              </a></li>
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                <li >
−
            <li id="Entrepreneurship">
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                <a href="/Team:DTU-Denmark/Project/MAGE"
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            <a href="/Team:DTU-Denmark/Entrepreneurship"
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                  >MAGE subtilis
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              >Entrepreneurship
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                  </a></li>
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              </a></li>
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                <li >
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        <li class="hidden-xs">
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                <a href="/Team:DTU-Denmark/Project/Tyrocidine"
−
          <a href="http://facebook.com/dtubiobuilders" data-toggle="tooltip" data-placement="bottom" title="Follow us on Facebook">
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                  >Tyrocidine
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            <i class="fa fa-facebook"></i><span class="visible-xs"> Follow us on Facebook</span>
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                  </a></li>
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          </a>
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                <li >
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        </li>
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                <a href="/Team:DTU-Denmark/Project/Chip"
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        <li class="visible-xs"><a href="http://facebook.com/dtubiobuilders"><i class="fa fa-facebook-square"></i> Follow us on Facebook</a></li>
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                  >Lab-on-a-disc
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        <li class="hidden-xs">
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                  </a></li>
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          <a href="https://twitter.com/IGEM_DTU" data-toggle="tooltip" data-placement="bottom" title="Follow us on Twitter">
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                <li >
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            <i class="fa fa-twitter"></i>
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                <a href="/Team:DTU-Denmark/Project/Inteins"
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          </a>
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                  >Inteins
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        </li>
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                  </a></li>
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        <li class="visible-xs"><a href="https://twitter.com/IGEM_DTU"><i class="fa fa-twitter-square"></i> Follow us on Twitter</a></li>
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                <li >
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        <li class="hidden-lg">
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                <a href="/Team:DTU-Denmark/Project/Detection"
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          <a href="https://igem.org" target="_blank" class="navimg">
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                  >Detection of NRP
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            <img src="/_themes/dtu/images/igemlogo.png">
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                  </a></li></ul></li>
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          </a>
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                <li >
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        </li>
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                <a href="/Team:DTU-Denmark/Practices"
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      </ul>
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                  >Human Practices
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    </div><!-- /.navbar-collapse -->
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                  </a></li>
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  </div>
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                <li  
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</nav>
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 +
                   
 +
               
 +
                   
 +
               
 +
                >
 +
                <a href=""
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                  class="dropdown-toggle"
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                  data-toggle="dropdown"
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                  role="button"
 +
                  aria-expanded="false">Parts Collection
 +
                  <span class="caret"></span></a><ul class="dropdown-menu" role="menu">
 +
                <li >
 +
                <a href="/Team:DTU-Denmark/Parts"
 +
                  >Parts
 +
                  </a></li>
 +
                <li >
 +
                <a href="/Team:DTU-Denmark/Description"
 +
                  >Characterisation of xylR
 +
                  </a></li></ul></li>
 +
                <li >
 +
                <a href="/Team:DTU-Denmark/Journal"
 +
                  >Journal
 +
                  </a></li>
 +
                <li >
 +
                <a href="/Team:DTU-Denmark/Software"
 +
                  >Software
 +
                  </a></li>
 +
                <li  
 +
               
 +
                   
 +
               
 +
                   
 +
               
 +
                   
 +
               
 +
                >
 +
                <a href=""
 +
                  class="dropdown-toggle"
 +
                  data-toggle="dropdown"
 +
                  role="button"
 +
                  aria-expanded="false">Achievements
 +
                  <span class="caret"></span></a><ul class="dropdown-menu" role="menu">
 +
                <li >
 +
                <a href="/Team:DTU-Denmark/Achievements"
 +
                  >Key Achievements
 +
                  </a></li>
 +
                <li >
 +
                <a href="/Team:DTU-Denmark/Collaborations"
 +
                  >Collaborations
 +
                  </a></li>
 +
                <li >
 +
                <a href="/Team:DTU-Denmark/Judging_Form"
 +
                  >Judging Form
 +
                  </a></li></ul></li>
 +
            <li class="hidden-xs">
 +
              <a href="http://facebook.com/dtubiobuilders" data-toggle="tooltip" data-placement="bottom" title="Follow us on Facebook">
 +
                <i class="fa fa-facebook"></i><span class="visible-xs"> Follow us on Facebook</span>
 +
              </a>
 +
            </li>
 +
            <li class="visible-xs"><a href="http://facebook.com/dtubiobuilders"><i class="fa fa-facebook-square"></i> Follow us on Facebook</a></li>
 +
            <li class="hidden-xs">
 +
              <a href="https://twitter.com/IGEM_DTU" data-toggle="tooltip" data-placement="bottom" title="Follow us on Twitter">
 +
                <i class="fa fa-twitter"></i>
 +
              </a>
 +
            </li>
 +
            <li class="visible-xs"><a href="https://twitter.com/IGEM_DTU"><i class="fa fa-twitter-square"></i> Follow us on Twitter</a></li>
 +
            <li class="hidden-lg">
 +
              <a href="https://igem.org" target="_blank" class="navimg">
 +
                <img src="https://static.igem.org/mediawiki/2015/a/af/DTU-Denmark_igemlogo.png">
 +
              </a>
 +
            </li>
 +
          </ul>
 +
        </div><!-- /.navbar-collapse -->
 +
      </div>
 +
    </nav>
 +
 
 +
 
 
<nav class="navbar navbar-default extrabar hidden-xs hidden" data-spy="affix">
 
<nav class="navbar navbar-default extrabar hidden-xs hidden" data-spy="affix">
 
   <div class="container-fluid" id="scrollspy">
 
   <div class="container-fluid" id="scrollspy">
 
     <ul class="nav navbar-nav">
 
     <ul class="nav navbar-nav">
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       <li><a class="page-scroll" href="#Introduction">Introduction</a></li><li><a class="page-scroll" href="#References">References</a></li><li><a class="page-scroll" href="#Timeline">Timeline</a></li>
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       <li><a class="page-scroll" href="#ProjectDescription">Project Description</a></li><li><a class="page-scroll" href="#SocialMedia">Social Media</a></li>
 
     </ul>
 
     </ul>
 
   </div>
 
   </div>
 
</nav>
 
</nav>
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<div class="jumbotron hero" style="background-image: url(/_themes/dtu/images/hero.jpg)">
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<div class="jumbotron hero" style="background-image: url(https://static.igem.org/mediawiki/2015/0/0b/DTU-Denmark_hero.jpg)">
 
       <div class="igem-logo visible-lg">
 
       <div class="igem-logo visible-lg">
 
         <a href="https://igem.org" target="_blank">
 
         <a href="https://igem.org" target="_blank">
−
           <img src="/_themes/dtu/images/igemlogo.png">
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           <img src="https://static.igem.org/mediawiki/2015/a/af/DTU-Denmark_igemlogo.png">
 
         </a>
 
         </a>
 
       </div>
 
       </div>
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             <hr/>
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             <ul class="list-inline hidden-xs hidden-sm">
 
             <ul class="list-inline hidden-xs hidden-sm">
 
                
 
                
 
               <li>
 
               <li>
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                 <a id="Introduction-submenu" class="btn btn-default btn-transparent btn-lg page-scroll" href="#Introduction">Introduction</a>
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                 <a id="ProjectDescription-submenu" class="btn btn-default btn-transparent btn-lg page-scroll" href="#ProjectDescription">Project Description</a>
 
               </li>
 
               </li>
 
                
 
                
 
               <li>
 
               <li>
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                 <a id="References-submenu" class="btn btn-default btn-transparent btn-lg page-scroll" href="#References">References</a>
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                 <a id="SocialMedia-submenu" class="btn btn-default btn-transparent btn-lg page-scroll" href="#SocialMedia">Social Media</a>
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              </li>
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              <li>
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                <a id="Timeline-submenu" class="btn btn-default btn-transparent btn-lg page-scroll" href="#Timeline">Timeline</a>
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               </li>
 
               </li>
 
                
 
                
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               <li>
 
               <li>
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                 <a id="Introduction-submenu" class="page-scroll" href="#Introduction">Introduction</a>
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                 <a id="ProjectDescription-submenu" class="page-scroll" href="#ProjectDescription">Project Description</a>
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              </li>
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              <li>
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                <a id="References-submenu" class="page-scroll" href="#References">References</a>
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         <p style="text-align: center;"><span style="font-size:72px;"><span style="font-size:72px;"><span class="fa fa-headphones" style="color:rgb(0, 0, 0);"></span></span></span></p>
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<p style="text-align: center;">Listen to our podcast about our <a href="https://static.igem.org/mediawiki/2015/5/50/Podcast_project.mp4"><em>Project</em></a>&nbsp;or&nbsp;<a href="https://static.igem.org/mediawiki/2015/f/f5/Podcast_education.mp4"><em>Human practises</em></a></p>
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DTU Denmark received a gold medal at the Giant Jamboree in Boston 2015 and a nomination for best educational human practises. Click on the headphones to hear our podcasts explaining our project and our human practises.</p>
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<p>We also designed a <a href="https://2015.igem.org/Team:DTU-Denmark/Software">Wiki Wizard</a> that allows you to easily create and design wikis without knowing about HTML, CSS, and JavaScript. By using the shared editing mode, team members can edit the Wiki at the same time - just like Google Docs.</p>
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<p>Nonribosomal peptides have important anti-bacterial, anti-cancer, and immunosuppressive biological activities. They are synthesized by modular, high molecular weight enzymes that assemble more than 500 different amino acid substrates in an assembly line manner. For this reason, synthetic biologists have tried to engineer these proteins and to switch modules to create analogs and novel natural products, but with little success. Despite being modular, the interactions between modules have evolved to be highly specific, making synthetic Non-Ribosomal Peptide Synthases (NRPS) a challenge to engineer. Instead of switching modules we introduced a recombination system targeting oligo integration in Bacillus subtilis. We used the recombineering system to alter the active sites determining substrate specificity, thereby creating variants of antibiotics. Our focus was the tyrocidine antibiotic, which cannot be used intravenously due to its toxicity. Our goal is to create new analogs through multiplex automated genome engineering to reduce toxicity.</p>
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<p><a class="twitter-timeline" data-widget-id="631150747221139456" href="https://twitter.com/iGEM_DTU">Tweets by @iGEM_DTU</a> <script>!function(d,s,id){var js,fjs=d.getElementsByTagName(s)[0],p=/^http:/.test(d.location)?'http':'https';if(!d.getElementById(id)){js=d.createElement(s);js.id=id;js.src=p+"://platform.twitter.com/widgets.js";fjs.parentNode.insertBefore(js,fjs);}}(document,"script","twitter-wjs");</script></p>
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  <li>Bonde, M. T., Klausen, M. S., Anderson, M. V., Wallin, A. I. N., Wang, H. H., & Sommer, M. O. A. (2014). MODEST: a web-based design tool for oligonucleotide-mediated genome engineering and recombineering. Nucleic Acids Research, 42(W1), W408–W415. <a href="http://dx.doi.org/10.1093/nar/gku428" target="_blank">doi:10.1093/nar/gku428</a></li>
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            <strong>Technical University of Denmark</strong><br>
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            Department of Systems Biology <br>
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            Søltofts Plads 221 <br>
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            2800 Kgs. Lyngby<br>
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            Denmark<br>
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            <abbr title="Phone">P:</abbr> +45 45 25 25 25<br>
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             <p><small class="text-muted"><i class="glyphicon glyphicon-time"></i> 2015-09-27</small></p>
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Latest revision as of 23:51, 20 November 2015

Technical University of Denmark

The Synthesizer

Scroll down for more

Project Description

Listen to our podcast about our Project or Human practises

 


DTU Denmark received a gold medal at the Giant Jamboree in Boston 2015 and a nomination for best educational human practises. Click on the headphones to hear our podcasts explaining our project and our human practises.

We also designed a Wiki Wizard that allows you to easily create and design wikis without knowing about HTML, CSS, and JavaScript. By using the shared editing mode, team members can edit the Wiki at the same time - just like Google Docs.

 

Nonribosomal peptides have important anti-bacterial, anti-cancer, and immunosuppressive biological activities. They are synthesized by modular, high molecular weight enzymes that assemble more than 500 different amino acid substrates in an assembly line manner. For this reason, synthetic biologists have tried to engineer these proteins and to switch modules to create analogs and novel natural products, but with little success. Despite being modular, the interactions between modules have evolved to be highly specific, making synthetic Non-Ribosomal Peptide Synthases (NRPS) a challenge to engineer. Instead of switching modules we introduced a recombination system targeting oligo integration in Bacillus subtilis. We used the recombineering system to alter the active sites determining substrate specificity, thereby creating variants of antibiotics. Our focus was the tyrocidine antibiotic, which cannot be used intravenously due to its toxicity. Our goal is to create new analogs through multiplex automated genome engineering to reduce toxicity.

 

Social Media

DTU Biobuilders
Technical University of Denmark
Department of Systems Biology
Søltofts Plads 221
2800 Kgs. Lyngby
Denmark
P: +45 45 25 25 25
M: dtu-igem-2015@googlegroups.com