Difference between revisions of "Team:HSNU-TAIPEI/projectcopper"

 
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<a>Project</a>
 
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<li class="list-item"><a href="https://2015.igem.org/Team:HSNU-TAIPEI/projectoverview">Overview</a></li>
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<li class="list-item"><a href="https://2015.igem.org/Team:HSNU-TAIPEI/projectBP">Benzo[A]Pyrene</a></li>
 
<li class="list-item"><a href="https://2015.igem.org/Team:HSNU-TAIPEI/projectBP">Benzo[A]Pyrene</a></li>
 
<li class="list-item"><a href="https://2015.igem.org/Team:HSNU-TAIPEI/projectcopper">Copper</a></li>
 
<li class="list-item"><a href="https://2015.igem.org/Team:HSNU-TAIPEI/projectcopper">Copper</a></li>
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<li class="list-item"><a href="https://2015.igem.org/Team:HSNU-TAIPEI/projectlead">Cadmium</a></li>
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<li class="list-item"><a href="https://2015.igem.org/Team:HSNU-TAIPEI/projectcadmium">Cadmium</a></li>
 
<li class="list-item"><a href="https://2015.igem.org/Team:HSNU-TAIPEI/projectmercury">Mercury</a></li>
 
<li class="list-item"><a href="https://2015.igem.org/Team:HSNU-TAIPEI/projectmercury">Mercury</a></li>
 
<li class="list-item"><a href="https://2015.igem.org/Team:HSNU-TAIPEI/projectlead">Lead</a></li>
 
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<a>Human Practice</a>
 
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<h1>Project<span><em>Copper</em></span></h1>
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              <h3 class="article-title">Introduction</h3>
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                  <span>銅的危害</span>
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                  <p class="article-p">銅是呼吸色素的必須成分，並在越來越多的蛋白質和酶中檢測到。1847年Harless就指出軟體動物內的銅具有重要作用；1878年Frederig首先從章魚血內蛋白質複合物中將銅分離出來，並將這種含銅蛋白質命名為銅藍蛋白；1928年Hart報告銅為哺乳動物的必須元素。</p>
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                  <p class="article-p">根據文獻，因為銅會影響鐵的吸收所以缺乏銅會導致白血球異常，嗜中性白血球減少症 (Neutropenia)，以及骨質疏鬆、生長遲緩等等問題。[1] 或是影響免疫系統。[2]</p>
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                  <p class="article-p">而過多的銅也會對人體造成危害，吸入高濃度的銅會導致鼻子喉嚨的刺激。攝入高濃度的銅會造成肝臟及腎臟的損害。[3]銅過量會中毒，症狀包括反胃、噁心、嘔吐、腹瀉。其它嚴重症狀包含血尿、黃疸、寡尿。銅中毒時可發生溶血、血紅蛋白降低, 血清乳酸脫氫酶升高以及腦組織病變等。[4]而遺傳疾病威爾遜病也與銅有關，其是因為先天原因導致P型銅轉運ATP酶缺陷，使銅過量聚集於肝臟周圍而使肝細胞壞死，接著銅藉由血液沉積在腦、腎、角膜等肝外組織而致病。[5]</p>
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                  <span>相關法規</span>
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                      <span>United States</span>
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                        <li>美國環保署要求飲用水中銅濃度不能超過1.3 mg/L。</li>
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                        <li>美國農業部建議八歲以上的人們每天准許含量為900 mg。</li>
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                        <li>美國職業安全及健康管理局(OSHA)要求工作場所中，空氣裡銅的含量不能超過0.1 mg/m3以及含銅的塵土不能超過0.1 mg/m3。</li>
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                      <span>Taiwan</span>
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                        <li>飲用水 1.0 ppm</li>
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                        <li>Cooking oil 0.4 ppm</li>
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                        <li>Egg 5 ppm</li>
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              <h3 class="article-title">Circuit Design</h3>
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              <p class="article-p">Just like detecting cadmium , we use the same principle on copper. First, we use the CopA Promoter , which can detect copper and more sensitive than CueO Promoter. When it detects that there is copper in oil, then it will activate the translation reverse.</p>
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              <h3 class="article-title">研究問題與結果</h3>
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<span>此毒物能否進入ecoli</span>
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<span>大腸桿菌能否在銅中存活?</span>
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<span>銅濃度與螢光亮度的關係</span>
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<h3 class="article-title">Reference</h3>
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<li>[1]<a href="http://www.cmuh.cmu.edu.tw/temp_file/54CBAA2CF894BA9A1FCDCF9DFD9432D8/teaching/file/2014-01-03_09-13/%E9%8A%85%E8%88%87%E9%8A%85%E4%B8%AD%E6%AF%92.pdf">銅與銅中毒 - 中國醫藥大學附設醫院</a></li>
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<li>[2]<a href="http://www.cqvip.com/QK/94462X/199602/">《国外医学情报》1996年 第2期 | 张尚文 </a></li>
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<li>[3]<a href="http://nehrc.nhri.org.tw/toxic/toxfaq_detail.php?id=51">國家環境毒物研究中心</a></li>
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<li>[4]曹会兰 微量元素与健康研究 2001 年第 18 卷第3期</li>
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                <li>[5]<a href="https://www.ntuh.gov.tw/neur/%E8%A1%9B%E6%95%99%E8%B3%87%E6%96%99/DocLib/%E9%81%BA%E5%82%B3%E6%80%A7%E7%96%BE%E7%97%85/%E5%A8%81%E7%88%BE%E6%A3%AE%E6%B0%8F%E7%97%87.aspx">台大醫院 衛教資料</a></li>
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<p><a href="http://www.hs.ntnu.edu.tw">HSNU | Taipei</a></p>
 
<p><a href="http://www.hs.ntnu.edu.tw">HSNU | Taipei</a></p>
 
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Latest revision as of 01:09, 26 November 2015