Difference between revisions of "Team:ATOMS-Turkiye/Description"

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<h2> Project Description </h2>
 
<h2> Project Description </h2>
  
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<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
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<p>This year, our team’s main goal is to cure the gastric ulcer and the cancer.
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Gastric ulcer is caused mainly by Helicobacter pylori. This bacteria is a gram-negative bacteria that effects more than 50% of human population.  As a health and medicine team of medical students, we decided to eradicate H. pylori because it causes ulcer and maybe gastric cancer in next stages but these diseases can not cured completely with the recent treatments.
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In design of our project, we had 2 different modules, which have submodules under them. First module is eradication of the H. pylori and second module is a switch system to cure cancer. For eradication of H. pylori (Module I), we decided to modify E. coli to produce Pexiganan (an antimicrobial peptide which can kill H. pylori) and having acid resistant and make its flagella faster for penetration,
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<h5>What should this page contain?</h5>
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To cure the cancer (Module II); we designed switch systems which are based on differences of miRNA concentration between normal cells and cancer cells. We have two different switch systems, miRNA level dependent system and independent system. After many researches we found out that miRNA levels and their variety can be really useful to classify cells as normal and cancer cells. Our system is designed to sense the levels of miRNAs, which are down-regulated or up-regulated in cancer cells, and start to apoptosis process.
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<li> A clear and concise description of your project.</li>
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<li>A detailed explanation of why your team chose to work on this particular project.</li>
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<li>References and sources to document your research.</li>
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<li>Use illustrations and other visual resources to explain your project.</li>
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<h4>Advice on writing your Project Description</h4>
 
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.
 
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Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.
 
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<h4>References</h4>
 
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you though about your project and what works inspired you.</p>
 
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<h4>Inspiration</h4>
 
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<p>See how other teams have described and presented their projects: </p>
 
  
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<li><a href="https://2014.igem.org/Team:Imperial/Project"> Imperial</a></li>
 
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> UC Davis</a></li>
 
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<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">SYSU Software</a></li>
 
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Latest revision as of 00:45, 16 July 2015

Project Description

This year, our team’s main goal is to cure the gastric ulcer and the cancer. Gastric ulcer is caused mainly by Helicobacter pylori. This bacteria is a gram-negative bacteria that effects more than 50% of human population. As a health and medicine team of medical students, we decided to eradicate H. pylori because it causes ulcer and maybe gastric cancer in next stages but these diseases can not cured completely with the recent treatments. In design of our project, we had 2 different modules, which have submodules under them. First module is eradication of the H. pylori and second module is a switch system to cure cancer. For eradication of H. pylori (Module I), we decided to modify E. coli to produce Pexiganan (an antimicrobial peptide which can kill H. pylori) and having acid resistant and make its flagella faster for penetration, To cure the cancer (Module II); we designed switch systems which are based on differences of miRNA concentration between normal cells and cancer cells. We have two different switch systems, miRNA level dependent system and independent system. After many researches we found out that miRNA levels and their variety can be really useful to classify cells as normal and cancer cells. Our system is designed to sense the levels of miRNAs, which are down-regulated or up-regulated in cancer cells, and start to apoptosis process.