Difference between revisions of "Team:Warwick/Modelling5"

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<h5 class="sidebartitle">Cube Construction</h5>

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<p> One idea for a 3-D structure was, with the use of zinc fingers, small cubes of DNA (6 x 6 x 6nm) being bound together to form a megastructure large enough for E-coli cells (size: 2 x 0.5 x 0.5 µm) to bind to with reasonable rates of success. </p>

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<img src="https://static.igem.org/mediawiki/2015/b/b0/3D_cube_assembly.png" class="pics" alt=""> The aim of this model is to design a 3D, self-assembling structure which forms a shape which allows E-coli cells to be bonded to the outside. One of the shapes we decided to use is a geodesic sphere made up of multiple tetrahedron ‘bricks’. Tetrahedrons are the strongest 3D structure and would allow any sized scaffold to be made. A sphere is the best 3D structure as it has the largest surface area to volume ratio which will allow the largest number of E.coli cells to bond to it.

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<br>The first two images are how the tetrahedrons are made, using DNA origami. Our sequences will be designed so that each side will have DNA hairpins which bond to another side of a different tetrahedron. The last image is what the DNA origami structure will look like once it has been made.

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~~Each side of the tetrahedrons will have the binding sequences needed to bind the E.coli cells to the outside of the structure, so that it doesn’t matter where each tetrahedron goes.~~

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Difference between revisions of "Team:Warwick/Modelling5"

Revision as of 11:08, 19 August 2015

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 			<div class="fifteen columns noleftmargin">
 			<h5 class="sidebartitle">Cube Construction</h5>
-			<p>
+			<p> One idea for a 3-D structure was, with the use of zinc fingers, small cubes of DNA (6 x 6 x 6nm) being bound together to form a megastructure large enough for E-coli cells (size: 2 x 0.5 x 0.5 µm) to bind to with reasonable rates of success. </p>
-			<img src="https://static.igem.org/mediawiki/2015/b/b0/3D_cube_assembly.png" class="pics" alt=""> The aim of this model is to design a 3D, self-assembling structure which forms a shape which allows E-coli cells to be bonded to the outside. One of the shapes we decided to use is a geodesic sphere made up of multiple tetrahedron ‘bricks’. Tetrahedrons are the strongest 3D structure and would allow any sized scaffold to be made. A sphere is the best 3D structure as it has the largest surface area to volume ratio which will allow the largest number of E.coli cells to bond to it.
+			<img src="https://static.igem.org/mediawiki/2015/b/b0/3D_cube_assembly.png" class="pics" alt="">
-<br>The first two images are how the tetrahedrons are made, using DNA origami. Our sequences will be designed so that each side will have DNA hairpins which bond to another side of a different tetrahedron. The last image is what the DNA origami structure will look like once it has been made.
-Each side of the tetrahedrons will have the binding sequences needed to bind the E.coli cells to the outside of the structure, so that it doesn’t matter where each tetrahedron goes.
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      <p style="float: left;"><img src="https://static.igem.org/mediawiki/2015/0/05/WarwickCaddy.png" height="200px" width="300px" border="1px"></p>