Difference between revisions of "Team:Tuebingen/Practices"

Line 2: Line 2:
 
<html>
 
<html>
  
−
<h2> Project Description</h2>
+
<h2> Human Practices </h2>
  
−
<h4> A Biosensor Memory Module: Cre Sensor</h4>
+
<p>iGEM teams are unique and leading the field because they "go beyond the lab" to imagine their projects in a social/environmental context, to better understand issues that might influence the design and use of their technologies.</p>
 +
<p>Teams work with students and advisors from the humanities and social sciences to explore topics concerning ethical, legal, social, economic, safety or security issues related to their work. Consideration of these Human Practices is crucial for building safe and sustainable projects that serve the public interest. </p>
 +
<p>For more information, please see the <a href="https://2015.igem.org/Practices_Hub">Practices Hub</a>.</p>
  
−
<p>Analysis and imaging methods are an indispensable element of every scientific study - in a wider sense the results are only as good as their measurement methods.<br/>
+
<div class="highlightBox">
−
Photostimulation is one of the most important non-invasive analysis methods allowing researchers to examine the relationship between metabolic processes, e.g. through activating a molecule via light treatment. We want to create a module which makes it possible to take a snapshot of the activity of a sensor at any time.
+
<h4>Note</h4>
−
Our designed system should be capable of capturing such a ‘snapshot’ of the activity of a sensor. Therefore our aim is to create a Cre recombinase whose activity can be reversibly controlled by light. By activating this construct only for a short period of time, we can use a Cre to switch on expression of Luciferase in only a limited amount of the sensor cells. Through coupling the Cre expression to the sensor we can thereby permanently write the sensor state of a given time point into the DNA of a system. </p>
+
<p>You must fill out this page in order to be considered for all <a href="https://2015.igem.org/Judging/Awards">awards</a> for Human Practices:</p>
 +
<ul>
 +
<li>Human Practices silver medal criterion</li>
 +
<li>Human Practices gold medal criterion</li>
 +
<li>Best Integrated Human Practices award</li>
 +
<li>Best Education and Public Engagement award</li>
 +
</ul>
 +
</div>
  
−
<p>
 
−
To achieve the construction of a reversibly activatable Cre recombinase we want to apply the caging mechanism described by Zhou et al [1]. This caging is performed by fusing a copy of a variant of the fluorescent protein Dronpa to both the C- and N-terminus of the Cre recombinase. Since this Dronpa variant is able to form monomers or dimers depending on illumination with light of different wavelengths, we hope that the dimerized form inhibits the activity of the Cre recombinase. </p>
 
  
−
<p>
+
<h5>Some Human Practices topic areas </h5>
−
Because our system only needs the expression of the caged Cre construct to be dependent on a sensor, it can be combined with almost all Biosensors that include a means of transcriptional control. This gives the system a wide variety of possible applications, especially in the context of the work of other iGEM teams.</p>
+
<ul>
 +
<li>Philosophy</li>
 +
<li>Public Engagement / Dialogue</li>
 +
<li>Education</li>
 +
<li>Product Design</li>
 +
<li>Scale-Up and Deployment Issues</li>
 +
<li>Environmental Impact</li>
 +
<li>Ethics</li>
 +
<li>Safety</li>
 +
<li>Security</li>
 +
<li>Public Policy</li>
 +
<li>Law and Regulation</li>
 +
<li>Risk Assessment</li>
 +
</ul>
  
−
<p>[1] Zhou, XX; Chung, HK; Lam, AJ & Lin, MZ. (2012). Optical control of protein activity by fluorescent protein domains. Science, 338(6108), 810-814.</p>
+
<h5>What should we write about on this page?</h5>
 +
<p>On this page, you should write about the Human Practices topics you considered in your project, and document any special activities you did (such as visiting experts, talking to lawmakers, or doing public engagement).</p>
  
 +
 +
<h5>Inspiration</h5>
 +
<p>Read what other teams have done:</p>
 +
<ul>
 +
<li><a href="https://2014.igem.org/Team:Dundee/policypractice/experts">2014 Dundee </a></li>
 +
<li><a href="https://2014.igem.org/Team:UC_Davis/Policy_Practices_Overview">2014 UC Davis </a></li>
 +
<li><a href="https://2013.igem.org/Team:Manchester/HumanPractices">2013 Manchester </a></li>
 +
<li><a href="https://2013.igem.org/Team:Cornell/outreach">2013 Cornell </a></li>
 +
</ul>
 +
 +
<h3>Integrated Human Practices</h3>
 +
 +
<p>Do you want to be considered for the <a href="https://2015.igem.org/Judging/Awards#SpecialPrizes">Best Integrated Human Practices award</a>? Make it easy for the judges to find any wiki content that is relevant to this prize. Highlight this content with a header or separate section.</p>
 +
 +
<h3>Education and Public Engagement</h3>
 +
 +
<p>Do you want to be considered for the <a href="https://2015.igem.org/Judging/Awards#SpecialPrizes">Best Education and Public Outreach award</a>? Make it easy for the judges to find any wiki content that is relevant to this prize. Highlight this content with a header or separate section.</p>
  
  
 
</div>
 
</div>
 
</html>
 
</html>

Revision as of 12:15, 19 August 2015

<
>

Human Practices

iGEM teams are unique and leading the field because they "go beyond the lab" to imagine their projects in a social/environmental context, to better understand issues that might influence the design and use of their technologies.

Teams work with students and advisors from the humanities and social sciences to explore topics concerning ethical, legal, social, economic, safety or security issues related to their work. Consideration of these Human Practices is crucial for building safe and sustainable projects that serve the public interest.

For more information, please see the Practices Hub.

Note

You must fill out this page in order to be considered for all awards for Human Practices:

  • Human Practices silver medal criterion
  • Human Practices gold medal criterion
  • Best Integrated Human Practices award
  • Best Education and Public Engagement award
Some Human Practices topic areas
  • Philosophy
  • Public Engagement / Dialogue
  • Education
  • Product Design
  • Scale-Up and Deployment Issues
  • Environmental Impact
  • Ethics
  • Safety
  • Security
  • Public Policy
  • Law and Regulation
  • Risk Assessment
What should we write about on this page?

On this page, you should write about the Human Practices topics you considered in your project, and document any special activities you did (such as visiting experts, talking to lawmakers, or doing public engagement).

Inspiration

Read what other teams have done:

Integrated Human Practices

Do you want to be considered for the Best Integrated Human Practices award? Make it easy for the judges to find any wiki content that is relevant to this prize. Highlight this content with a header or separate section.

Education and Public Engagement

Do you want to be considered for the Best Education and Public Outreach award? Make it easy for the judges to find any wiki content that is relevant to this prize. Highlight this content with a header or separate section.