Difference between revisions of "Team:Shenzhen SFLS"
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| − | <h2> Welcome to iGEM | + | <h2> Welcome to iGEM Shenzhen_SFLS! |
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| − | < | + | Project at a glimpse: |
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| − | + | This year Shenzhen_SFLS aims to build a system connected to the interactions between antibody and antigen and to apply it to a brand new cancer therapy called CAR-T cell. Using synthetic biological way, we constructed a fused protein which was divided into three parts: an antigen tag, a flexible linker peptide and a medication molecule with the effect of destroying the targeted cell. Instead of the traditional method of improving the antibody’s affinity, we were just trying to reflect reversely and weaken the interactions to build this system. | |
| − | + | <br/> | |
| + | Our system complies with a simple logic rule that the antigen tag will constantly adhere to the antibody unless the targeted antigen appears. The tag is mutated from the original antigen so that it will have less hydrogen bond binding sites and weaker interaction with the antibody. Since a linker and a sort of medication are linked to the antigen tag, when it separates from the antibody, the medication can become effective immediately. | ||
| + | <br/> | ||
| + | After zooming in for further information about cancer therapy, we soon gained sufficient information of the most effective cancer therapy of this age called CAR-T cell. Chimeric antigen T cell therapy combines inborn immune reaction with synthetic biological method which can help T cells eliminate the interferences released by cancerous cells. Supplementary information of this therapy will be given in other parts of our wiki. | ||
| + | <br/> | ||
| + | We hope to be able to apply our project to cancer treatment for several reasons. How to defeat cancer remains an important worldwide problem and every day similar tragedies happen to our friends and families, classmates and teachers, leaving permanent scars on our souls. Young as we are, we hope to be able to make our own contributions to this issue. It cannot be neglected that our project acts as a guided missile against cancer and dramatically increases the lethality of CAR-T cells. In conclusion, our project has both realistic significance and academic value, and we will strive to achieve further accomplishments in this field. | ||
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Revision as of 14:56, 15 July 2015
Welcome to iGEM Shenzhen_SFLS!
Project at a glimpse:
This year Shenzhen_SFLS aims to build a system connected to the interactions between antibody and antigen and to apply it to a brand new cancer therapy called CAR-T cell. Using synthetic biological way, we constructed a fused protein which was divided into three parts: an antigen tag, a flexible linker peptide and a medication molecule with the effect of destroying the targeted cell. Instead of the traditional method of improving the antibody’s affinity, we were just trying to reflect reversely and weaken the interactions to build this system.
Our system complies with a simple logic rule that the antigen tag will constantly adhere to the antibody unless the targeted antigen appears. The tag is mutated from the original antigen so that it will have less hydrogen bond binding sites and weaker interaction with the antibody. Since a linker and a sort of medication are linked to the antigen tag, when it separates from the antibody, the medication can become effective immediately.
After zooming in for further information about cancer therapy, we soon gained sufficient information of the most effective cancer therapy of this age called CAR-T cell. Chimeric antigen T cell therapy combines inborn immune reaction with synthetic biological method which can help T cells eliminate the interferences released by cancerous cells. Supplementary information of this therapy will be given in other parts of our wiki.
We hope to be able to apply our project to cancer treatment for several reasons. How to defeat cancer remains an important worldwide problem and every day similar tragedies happen to our friends and families, classmates and teachers, leaving permanent scars on our souls. Young as we are, we hope to be able to make our own contributions to this issue. It cannot be neglected that our project acts as a guided missile against cancer and dramatically increases the lethality of CAR-T cells. In conclusion, our project has both realistic significance and academic value, and we will strive to achieve further accomplishments in this field.