Difference between revisions of "Team:Minnesota"

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    <title>iGEM Dundee 2013 · ToxiMop</title>
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    <meta name="description" content="A synthetic biology project called Toximop from the Dundee iGEM Team.">
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                      <li><a href="/Team:Dundee/Project"> ToxiMop Project </a></li>
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                      <!--<li><a href="/Team:Dundee/Project/LabOverview">Lab </a></li>-->
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                      <li><a href="/Team:Dundee/Project/MathOverview">Modelling </a></li>
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                      <li><a href="/Team:Dundee/Project/NetlogoIntro">Mop Simulation</a></li>
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                    <li><a href="/Team:Dundee/HumanPractice">Human Practice </a></li>
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                    <!--<li><a href="/Team:Dundee/Parts/Improvements">Improvements</a></li>-->
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                  </ul>
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                    <li class="nav-header">Lab</li>
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                  <!-- <li><a href="/Team:Dundee/Project/Mop">Mop</a></li>-->
 +
<li><a href="/Team:Dundee/Project/MopMaking">Making the Mop</a></li>
 +
<li><a href="/Team:Dundee/Project/MopQuantifying">Quantifying the Mop</a></li>
 +
<li><a href="/Team:Dundee/Project/MopTesting">Testing the Mop</a></li>
 +
                    <li><a href="/Team:Dundee/Project/Detector">Detector - EnvZ </a></li>
 +
                    <li><a href="/Team:Dundee/Project/ReporterOmpC">Reporter <i>ompC-GFP</i> </a></li>
 +
                    <li class="divider"></li>
 +
                    <li class="nav-header">Modelling </li>
 +
 
 +
                    <!--<li><a href="/Team:Dundee/Project/MathTheory">Modelling Theoryy</a></li>-->
 +
                    <li><a href="/Team:Dundee/Project/DetectionComparison">Detection Time</a></li>
 +
                    <li><a href="/Team:Dundee/Project/PP1Capacities">PP1 Packing</a></li>
 +
                    <li><a href="/Team:Dundee/Project/ProductionExport">Production &amp; Export </a></li>
 +
                    <li><a href="/Team:Dundee/Project/NetlogoDoc">Mop Simulation</a></li>
 +
 
 +
                    <li class="divider"></li>
 +
                    <li class="nav-header">Software &amp; Hardware</li>
 +
                  <li><a href="/Team:Dundee/Project/SoftwareTheory">Moptopus</a></li>
 +
                  <li><a href="/Team:Dundee/Project/NetlogoSec">Sec Simulation Applet</a></li>
 +
                  <li><a href="/Team:Dundee/Project/NetlogoTat">Tat Simulation Applet </a></li>
 +
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                    <li><a href="/Team:Dundee/Parts/Ourbiobricks">Our Biobricks</a></li>
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                    <!--<li><a href="/Team:Dundee/Parts/Improvements">Improvements</a></li>-->
 +
                  </ul>
 +
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                <li><a href="/Team:Dundee/Safety">Safety</a></li>
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<li class="dropdown">
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                    <li><a href="/Team:Dundee/Team">Meet the Team</a></li>
 +
                    <li><a href="https://igem.org/Team.cgi?id=1012">Team Information</a></li>
 +
                    <li><a href="/Team:Dundee/Team/Gallery">Gallery</a></li>
 +
                    <li><a href="/Team:Dundee/Project/Notebook">Notebook</a></li>
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                    <li><a href="/Team:Dundee/Team/Contact">Contact</a></li>
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                    <li><a href="https://twitter.com/DundeeiGEMTeam">Twitter</a></li>
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                    <li><a href="https://plus.google.com/u/0/116223511035478208262/posts?hl=en_US">Google+</a></li>
 +
                    <li><a href="https://github.com/iGEMTeamDundee/ToxiMop">GitHub</a></li>
 +
                  </ul>
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                <li class="dropdown">
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                  <a href="#" class="dropdown-toggle" data-toggle="dropdown">Human Practice <!--<sup>*new</sup>--><b class="caret"></b></a>
 +
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 +
 
 +
                    <li><a href="/Team:Dundee/HumanPractice/Commercialisation ">
 +
 
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Commercialisation
 +
<div style=" 
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    font-size: 100%;
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    font-weight: bold;
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    line-height: 1;
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    color: rgb(66, 139, 202);
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    text-align: center;
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    white-space: nowrap;
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    vertical-align: baseline;
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    display: inline;">
 +
  <sup>*New</sup></div>
 +
 
 +
</a></li>
 +
 
 +
                    <li><a href="/Team:Dundee/HumanPractice/MoptopusCommercialisation ">
 +
Moptopus
 +
<div style="   
 +
    font-size: 75%;
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    font-size: 100%;
 +
    font-weight: bold;
 +
    line-height: 1;
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    color: rgb(66, 139, 202);
 +
    text-align: center;
 +
    white-space: nowrap;
 +
    vertical-align: baseline;
 +
    display: inline;">
 +
  <sup>*New</sup></div>
 +
 
 +
</a></li>
 +
 
 +
<li><a href="/Team:Dundee/HumanPractice/MediaCoverage">Media Coverage</a></li>
 +
                    <li><a href="/Team:Dundee/HumanPractice/PoliticalCampaign">Political Campaign</a></li>
 +
<li><a href="/Team:Dundee/HumanPractice/MediaCoverage">Media Coverage</a></li>
 +
                    <li><a href="/Team:Dundee/HumanPractice/CaseStudy">Clatto Case Study</a></li>
 +
                    <li><a href="/Team:Dundee/HumanPractice/PublicEngagement">Public Engagement</a></li>
 +
                    <!--<li><a href="/Team:Dundee/HumanPractice/Interviews">Interviews</a></li>-->
 +
                    <li><a href="/Team:Dundee/HumanPractice/Collaboration">Collaboration</a></li>
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 +
                    <li><a href="http://www.flickr.com/photos/97927329@N05/">Flickr</a></li>
 +
                    <li><a href="/Team:Dundee/HumanPractice/Comic">Comic</a></li>
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<li><a href="/Team:Dundee/Digi-Poster">Digital Poster</a></li>
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         <h2 style="margin-top:-10px;"> Targeting a Deadly Toxin</h2>
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        Explosions in the population of cyanobacteria can produce toxic algal blooms. Microcystin-LR the most potent and common algal bloom toxin, binds Protein Phosphatase 1. The average cyanobacteria infested lake in America contains over 1000 times the Microcystin safe drinking water limit set by the World Health Organisation. <br><br>
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        Concerned by a harmful algal bloom in the local community, we used synthetic biology to target the toxin. We exploited the mechanism of Microcystin's toxicity to develop our Mop; by expressing Protein Phosphatase 1 we can mop up Microcystin. The interaction was also the basis for developing a biological Detector. To deploy our Detector and to consider the root causes of algal blooms we created the electronic Moptopus. It sits on a lake and monitors conditions relevant to cyanobacterial growth to help predict future blooms.
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                          <p><b style="font-size:16px">Mop</b><br><br> Mopping up a toxin (microcystin) by engineering a bacterium to produce the human PP1 protein, the protein to which microcystin binds.</p>
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                          <p><b style="font-size:16px;">Detector</b><br><br> Detecting microcystin by manipulation of the <i>E. coli</i> osmoregulator EnvZ.</p>
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                          <p><b style="font-size:16px;">Moptopus</b><br><br>  An electronic sensing device that provides a platform for toxin detection. It relates a range of environmental conditions to algal bloom formation and toxicity.</p>
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Revision as of 23:42, 2 September 2015

Team:Dundee - 2013.igem.org

 

Team:Dundee

From 2013.igem.org

iGEM Dundee 2013 · ToxiMop

Dundee 2013

Targeting a Deadly Toxin

Explosions in the population of cyanobacteria can produce toxic algal blooms. Microcystin-LR the most potent and common algal bloom toxin, binds Protein Phosphatase 1. The average cyanobacteria infested lake in America contains over 1000 times the Microcystin safe drinking water limit set by the World Health Organisation.

Concerned by a harmful algal bloom in the local community, we used synthetic biology to target the toxin. We exploited the mechanism of Microcystin's toxicity to develop our Mop; by expressing Protein Phosphatase 1 we can mop up Microcystin. The interaction was also the basis for developing a biological Detector. To deploy our Detector and to consider the root causes of algal blooms we created the electronic Moptopus. It sits on a lake and monitors conditions relevant to cyanobacterial growth to help predict future blooms.



Retrieved from "https://2013.igem.org/Team:Dundee"