Difference between revisions of "Team:SZU China/Team"
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+ | {{Template:Team:LMU-Munich/Playground/menu}} | ||
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+ | <link href="https://2014.igem.org/Team:LMU-Munich/home.css?action=raw&ctype=text/css" rel="stylesheet" type="text/css"> | ||
+ | <div id="home"> | ||
+ | <div id="home-logo"> | ||
+ | <a href="https://igem.org/Main_Page" target="_blank"> | ||
+ | <img src="https://static.igem.org/mediawiki/2014/8/8a/LMU_IGEMLogo.png" /> | ||
+ | </a> | ||
+ | </div> | ||
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+ | <div id="twopager"> | ||
+ | <a href="https://static.igem.org/mediawiki/2014/2/29/LMU14_2pager-final.pdf" target="_blank"> | ||
+ | <img src="https://static.igem.org/mediawiki/2014/3/37/LMU14_2pager.png" /> | ||
+ | </a> | ||
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+ | <div id="lmu-content2"> | ||
+ | <div id="tiles"> | ||
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+ | <a href="https://2014.igem.org/Team:LMU-Munich/Project/Problem"> | ||
+ | <img src="https://static.igem.org/mediawiki/2014/8/82/LMU14_home_button_problem.png" /> | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="col-xs-12 col-md-4"> | ||
+ | <a href="https://2014.igem.org/Team:LMU-Munich/Project/Bakillus"> | ||
+ | <img src="https://static.igem.org/mediawiki/2014/b/b1/LMU14_home_button_strategy.png" /> | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="col-xs-12 col-md-4"> | ||
+ | <a href="https://2014.igem.org/Team:LMU-Munich/Results"> | ||
+ | <img src="https://static.igem.org/mediawiki/2014/8/8e/LMU14_home-button-results.png" /> | ||
+ | </a> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | <div id="home-abstract"> | ||
+ | </html> | ||
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+ | <br/> | ||
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+ | =Abstract= | ||
+ | Increasing bacterial resistance to classical antibiotics remains a serious threat and urges the development of novel pathogen-killing strategies. Exploiting bacterial communication mechanisms such as quorum sensing is a promising strategy to specifically target certain pathogens. The major aim of this project is the introduction of a genetic circuit enabling ''Bacillus subtilis'' to actively detect, attach to, and eventually kill ''Staphylococcus aureus'' and ''Streptococcus pneumoniae''. | ||
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+ | Initially, we will introduce the autoinducer-sensing two-component systems of ''S. aureus'' and ''S. pneumoniae'' into ''B. subtilis''. to create a pathogen-detecting strain. By utilizing quorum sensing-dependent promoters, we will then trigger pathogen-killing strategies like the production of antimicrobial peptides or biofilm degradation. As a safety measure a delayed suicide-switch guarantees non-persistence of genetically modified ''B. subtilis'' in the absence of pathogens. We envision the use of BaKillus as a smart, cheap and simple-to-use medical device for diagnostics and targeted treatment of multiresistant super bugs. | ||
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+ | <div id="home-footer-wrapper"> | ||
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<h1>Team</h1> | <h1>Team</h1> | ||
<p>Why display like this</p> | <p>Why display like this</p> | ||
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</html> | </html> | ||
+ | {{Template:Team:LMU-Munich/Playground/footer}} | ||
+ | <html><script>initiateNavigation("none");</script></html> |
Revision as of 02:39, 12 September 2015
Template:Team:LMU-Munich/Playground/menu
Abstract
Increasing bacterial resistance to classical antibiotics remains a serious threat and urges the development of novel pathogen-killing strategies. Exploiting bacterial communication mechanisms such as quorum sensing is a promising strategy to specifically target certain pathogens. The major aim of this project is the introduction of a genetic circuit enabling Bacillus subtilis to actively detect, attach to, and eventually kill Staphylococcus aureus and Streptococcus pneumoniae.
Initially, we will introduce the autoinducer-sensing two-component systems of S. aureus and S. pneumoniae into B. subtilis. to create a pathogen-detecting strain. By utilizing quorum sensing-dependent promoters, we will then trigger pathogen-killing strategies like the production of antimicrobial peptides or biofilm degradation. As a safety measure a delayed suicide-switch guarantees non-persistence of genetically modified B. subtilis in the absence of pathogens. We envision the use of BaKillus as a smart, cheap and simple-to-use medical device for diagnostics and targeted treatment of multiresistant super bugs.
Team
Why display like this
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