Difference between revisions of "Team:UNC-Chapel Hill/Project"

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<h3 style="color:#56A0D3; font-size:30px">Project Introduction</h3>
 
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<p>Diabetes mellitus is prevalent throughout the world especially in the United States and Mexico. As a treatable disease, diabetes has fallen in the shadow of more life threatening diseases. Although treatable, diabetes can be life threatening, especially to those who cannot afford treatment options. As a solution, we propose a protein controlled system to sense glucose concentrations and release the needed proteins in response. This project executes the first crucial steps of creating a cost effective and accurate means of glucose sensing via the use of Escherichia coli. </p>
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<p>Our team aims to create a novel sensing device that enables one to quantitatively characterize the concentration, or presence of certain compounds. The theoretical advantages to our design include; a wider range of sensitivity, better accuracy, customizability, and ability to detect more than one input at any given time. </p>
 
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Revision as of 03:33, 17 September 2015

Tri Color Glucose Sensing System

Project Introduction

Our team aims to create a novel sensing device that enables one to quantitatively characterize the concentration, or presence of certain compounds. The theoretical advantages to our design include; a wider range of sensitivity, better accuracy, customizability, and ability to detect more than one input at any given time.

Results

  • Result 1 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.
  • Result 2 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.
  • Result 3 - Lorem ipsum ad his scripta blandit partiendo, eum fastidii accumsan euripidis in, eum liber hendrerit an.

Abstract Type One Type Two Modeling References

Abstract

This project introduces a novel glucose sensing system in which glucose-responsive promoters drive the expression of three reporter chromoproteins. We designed four novel glucose-sensitive promoters and tested their ability to drive expression of reporter chromoproteins at various glucose concentrations. In conjunction with existing glucose sensitive promoters from the Parts Registry, we used our novel promoters to design a biological device that expresses different combinations of the three different chromoproteins in response to glucose in Escherichia coli. As such, this device can detect a larger dynamic range of concentrations of selected molecules (e.g., glucose). Our project aims to provide a cheaper alternative for diabetics than current, more expensive, glucose-monitoring systems. While driven by this initial problem, continuing work has shown that our approach may have its greatest potential as a more general molecular sensing platform, capable of being easily customized for the sensing of a broad range of relevant compounds.

Type One Diabetes

Solution

Type 1 diabetes is characterized by the body’s immune system destroying insulin producing cells which leads the body to no longer producing insulin, a hormone that promotes the uptake of glucose by cells. We provide a solution for this problem through the creation of a pseudo beta cell that is able to produce insulin in the presence of high glucose level.

Type Two Diabetes

Solution

Type 2 diabetes is characterized by the body being inefficient in its use of insulin (insulin resistance) which causes the pancreas to decrease insulin production (insulin deficiency). Our potential solution for this is to have pseudo L cells release GLP-1 to promote insulin production. GLP-1 is an incretin. Incretins are a group of gastrointestinal hormones that stimulate a decrease in blood glucose levels. GLP-1 has been shown to promote insulin production and also to decrease glucagon production. Glucagon is a peptide hormone produced by alpha cells of the pancreas that raises the concentration of glucose in the bloodstream.

References

Thank You

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