Difference between revisions of "Team:Evry/Project/Mait"
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| − | <h1> | + | <h1>RiboVax</h1> |
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| − | <h2> | + | <h2>A new vaccinal vector targeting the MAIT Cells</h2> |
| − | <p> | + | <p> Mucosal-associated invariant T (MAIT) cells were first described by Tilloy et al. In 1999. |
| + | The interest in this unique subset of innate-like T-cells has increased rapidly over the last 5 years as novel findings have revealed their unique anti-bacterial function. MAIT cells represent the most abundant innate-like T-cell population within human beings, comprising up to ~5% of the total T-cell population. They are characterized by the expression of a semi-invariant TCR (Vα7.2-Jα33/12/20) that recognizes the MHC-like protein 1 (MR1), which presents a bacterial-derived ligand. Furthermore, MAIT cells have been associated with a number of disease settings, including bacterial infections, viral infections, and pro-inflammatory diseases such as multiple sclerosis and psoriasis. Thus, this large T lymphocyte population is likely to have an important role in human health. </p> | ||
<img src="https://static.igem.org/mediawiki/2015/e/ef/Fimmu-05-00450-g001.jpg" usemap="#imgmap2015916171923" id='image-map-py' width="1024"/> | <img src="https://static.igem.org/mediawiki/2015/e/ef/Fimmu-05-00450-g001.jpg" usemap="#imgmap2015916171923" id='image-map-py' width="1024"/> | ||
Revision as of 15:53, 18 September 2015
RiboVax
A new vaccinal vector targeting the MAIT Cells
Mucosal-associated invariant T (MAIT) cells were first described by Tilloy et al. In 1999. The interest in this unique subset of innate-like T-cells has increased rapidly over the last 5 years as novel findings have revealed their unique anti-bacterial function. MAIT cells represent the most abundant innate-like T-cell population within human beings, comprising up to ~5% of the total T-cell population. They are characterized by the expression of a semi-invariant TCR (Vα7.2-Jα33/12/20) that recognizes the MHC-like protein 1 (MR1), which presents a bacterial-derived ligand. Furthermore, MAIT cells have been associated with a number of disease settings, including bacterial infections, viral infections, and pro-inflammatory diseases such as multiple sclerosis and psoriasis. Thus, this large T lymphocyte population is likely to have an important role in human health.
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