Difference between revisions of "Team:NJU-China/Description"
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Illegal drugs are highly addictive and pose serious health risks. Addiction to drugs is a painful battle for the addict as well as for those individuals around him or her. Opioids and opiates top the list of problem drugs and cause the greatest burden of disease and drug-related deaths worldwide. The goal of this project was to develop a strategy to treat opioid addiction and to reduce relapse. Because opioids act primarily as Mu-opioid receptor (MOR) agonist to activate the reward pathway in the brain, leading to the euphoric effect of opioid drugs and ultimately the opioid-dependent state, blockage of the expression and function of MOR would theoretically have therapeutic value in the treatment of opioid dependence. Thus, this project selected MOR as a therapeutic target for the treatment of opioid addiction and for the prevention of a relapse to opioid use. | Illegal drugs are highly addictive and pose serious health risks. Addiction to drugs is a painful battle for the addict as well as for those individuals around him or her. Opioids and opiates top the list of problem drugs and cause the greatest burden of disease and drug-related deaths worldwide. The goal of this project was to develop a strategy to treat opioid addiction and to reduce relapse. Because opioids act primarily as Mu-opioid receptor (MOR) agonist to activate the reward pathway in the brain, leading to the euphoric effect of opioid drugs and ultimately the opioid-dependent state, blockage of the expression and function of MOR would theoretically have therapeutic value in the treatment of opioid dependence. Thus, this project selected MOR as a therapeutic target for the treatment of opioid addiction and for the prevention of a relapse to opioid use. | ||
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Revision as of 15:51, 18 September 2015
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