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| − | <h2>Project description</h2>
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| − | We feel strongly about the mission of synbio/iGEM to develop standardized DNA parts that can be used in imaginable ways to create useful and inspiring applications. You can even build modular systems with them. However, constructing a cell that is stimulated by a specific input and as a consequence releases a particulars output molecule or signal has to be done from scratch. Currently, there are no means of easily and quickly creating complex input/output intercellular pathways. We aim to change that.
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| − | Our idea of a solution is mating of yeast haploids. We will develop two different yeast haploids - one mating type for the input and the other one for the output cells. By their mating, diploids that react to specific input and produce the desired output can be rapidly constructed. By the use of orthogonal signals, we will be also able to use them in more complex circuits in order to detect specified input combinations
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| − | We are not only developing a modular I/O system platform, but also applying it to a real-world problem - cancer diagnosis from blood. Circulating tumor cells are cells that have shed from a primary tumor of the patient and are present in blood of a sick individual. In contrast to other healthy cells, tumor cells express proteins or glycoproteins on their surface, which are specific for a certain type of cancer. By recognizing these surface proteins and their combinations we could determine their exact origin.
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| − | We hope to prove that amplification of signal from only one tumor cell is possible and that it can lead to a specific agglutination reaction based on the marker being detected. Moreover, all of it done simply and rapidly. Firstly, the system ensures that sufficient amplification of signal from a single circulating tumor cell is produced. Secondly, our modified Saccharomyces cerevisiae yeast cells respond to such signal with a visible agglutination reaction.
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| − | <h2> Welcome to iGEM 2015! </h2>
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| − | <p>Your team has been approved and you are ready to start the iGEM season! </p>
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| − | <h4>Before you start: </h4>
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| − | <p> Please read the following pages:</p>
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| − | <ul>
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| − | <li> <a href="https://2015.igem.org/Requirements">Requirements page </a> </li>
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| − | <li> <a href="https://2015.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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| − | <h4> Styling your wiki </h4>
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| − | <p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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| − | <p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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| − | <h4> Editing your wiki </h4>
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| − | <p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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| − | <p> <a href="https://2015.igem.org/wiki/index.php?title=Team:Czech_Republic&action=edit"> Click here to edit this page! </a></p>
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| − | <p>See tips on how to edit your wiki on the <a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation</a> page.</p>
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| − | <h4>Templates </h4>
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| − | <p> This year we have created templates for teams to use freely. More information on how to use and edit the templates can be found on the
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| − | <a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation </a> page.</p>
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| − | <h4>Tips</h4>
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| − | <p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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| − | <li>State your accomplishments! Tell people what you have achieved from the start. </li>
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| − | <li>Be clear about what you are doing and how you plan to do this.</li>
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| − | <li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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| − | <li>Make sure information is easy to find; nothing should be more than 3 clicks away. </li>
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| − | <li>Avoid using very small fonts and low contrast colors; information should be easy to read. </li>
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| − | <li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2015.igem.org/Calendar_of_Events">iGEM 2015 calendar</a> </li>
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| − | <li>Have lots of fun! </li>
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| − | </ul>
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| − | <h4>Inspiration</h4>
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| − | <p> You can also view other team wikis for inspiration! Here are some examples:</p>
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| − | <ul>
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| − | <li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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| − | <li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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| − | <li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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| − | <li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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| − | <li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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| − | <li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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| − | </ul>
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| − | <h4> Uploading pictures and files </h4>
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| − | <p> You can upload your pictures and files to the iGEM 2015 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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| − | When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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| − | <a href="https://2015.igem.org/Special:Upload">CLICK HERE TO UPLOAD FILES</a>
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