Difference between revisions of "Team:TrinityCollegeDublin"

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<p>Synthetic artemisinin is perhaps the poster-child achievement of synthetic biology. Our team will work with artemisinic acid producing e-coli cells, obtained from Amyris, with the support of Zagaya. By expressing Dbr2, and other dehydrogenases in the artemisinin metabolic pathway we hope to improve the efficiency of artemisinin production. We have synthesized the bio-bricked components of the system, which should allow for an easier engagement with research on the topic in the future.</p>
 
<p>Synthetic artemisinin is perhaps the poster-child achievement of synthetic biology. Our team will work with artemisinic acid producing e-coli cells, obtained from Amyris, with the support of Zagaya. By expressing Dbr2, and other dehydrogenases in the artemisinin metabolic pathway we hope to improve the efficiency of artemisinin production. We have synthesized the bio-bricked components of the system, which should allow for an easier engagement with research on the topic in the future.</p>
 
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{{TrinityCollegeDublin}}
 
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Revision as of 16:44, 19 August 2015

Project Description

In our project, we will re-engineer the production of artemisinin in E-coli to hopefully provide a cheaper option with which to fight malaria. The disease is caused by the parasite, Plasmodium, and is transmitted in the bites of Anopheles mosquitoes that have picked up the parasite from other recently infected animals they have fed on. When left untreated, malaria can be fatal, disrupting proper blood flow and impeding the functions of vital organs in the body. The disease claims over 600,000 lives a year. Most of these lives are in poor underdeveloped regions, where people are unable to afford the drug.

Synthetic artemisinin is perhaps the poster-child achievement of synthetic biology. Our team will work with artemisinic acid producing e-coli cells, obtained from Amyris, with the support of Zagaya. By expressing Dbr2, and other dehydrogenases in the artemisinin metabolic pathway we hope to improve the efficiency of artemisinin production. We have synthesized the bio-bricked components of the system, which should allow for an easier engagement with research on the topic in the future.

Logo Final1.png




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