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                        <h2>Talking to Patients</h2>
 
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                                the process is not very different to using antibiotics
 
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                            During the process of talking to medical professionals, the importance of talking to patients as well was clear to us. On one occasion we spoke with Mavis, a patient staying on the Bedford Ward at the John Radcliffe Hospital. Her experience of urinary infections was that she had only suffered from them before having a catheter; since having a catheter fitted she hadn’t had any problems of infection. Her catheter was in place for up to 10 weeks. This enforced the importance of being able to keep our bacteria alive for a sustained period of time. When we asked her about treating infection with bacteria she said she would be happy to if it had been recommended to her by a doctor and told us that it is not dissimilar to using antibiotics.
 
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                        <h2>Further Feedback</h2>
 
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                            We are still designing a delivery system for our UTI treatment. We plan on asking the public to select from a variety of options, and then to design our treatment around the most popular one.
 
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                        <h2>Outreach</h2>
 
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                            To promote Synthetic Biology and iGEM, we’ve used a variety of approaches.
 
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                            <h3>UNIQ Workshop</h3>
 
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                                We met with 40 prospective Oxford students to teach them about Synthetic Biology. The students had in interest in Biochemistry but knew nothing about iGEM. We hammered home the key message of Synthetic Biology - that we achieve more progress by expanding a registry of standardised biological parts - through a 15 minute introductory presentation on BioBricks. We then split them into groups and gave each one a mentor from our iGEM team. We worked through questions to test their understanding in a tutorial style and asked them to explain the constructs of previous iGEM teams. They finished by presenting their findings to each other.
 
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                            <h3>UTC Oxfordshire</h3>
 
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                                A couple of us gave a presentation on antibiotic resistance to a class of GCSE students from UTC Oxfordshire (a local school specialising in science) at the Natural History Museum in Oxford, The Pitt Rivers Museum. Our talk covered the discovery of antibiotics, the advantages of them (including their use in laboratory work), how they work, and how bacteria can evolve to gain resistance to them, as well as concepts such as horizontal gene transfer and the consequences of antibiotic resistance on our everyday lives. It also covered our project outline, and pros and cons of Solution, showing how it should help combat antibiotic resistance. At the end, we held a discussion between the students and our team about antibiotic resistance, and their perception of the concern. We also asked how they would feel about using our engineered bacteria, and the response was positive, with most of the students saying that if their doctor recommended the treatment, they would be open to using it.
 
 
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                        <h2>Videos</h2>
 
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                            We’ve produced the following videos to promote our project and help future teams:
 
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                                Introduction to Oxford iGEM
 
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                                    Stochastic Modelling Tutorial (<a href="https://www.youtube.com/watch?v=xMy8oqP5Mis"> link</a>)<br>
 
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                    <h2>References</h2>
 
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                            [1] You can see all of our responses <a href="https://docs.google.com/document/d/1MAzVkPVVGAbAbFMIN9OIvZtC4vBpGkW2et9W3omnkzM/edit?usp=sharing">here</a>.
 
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                             <li><a href="#project-viability-increasing-awareness">Increasing Awareness</a></li>
 
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                        <a href="#further-feedback">Further Feedback</a>
 
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                        <a href="#outreach">Outreach</a>
 
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Revision as of 11:10, 7 September 2015

Practices

Introduction

Our project relies on a three way conversation between the team, the public and experts. It touches every aspect of the project, from our choice of application to the details of our delivery system. We promoted Synthetic Biology and iGEM through outreach programs to inspire the next generation.

Urinary tract infections are a huge problem globally with millions of cases reported each year. We’re producing a guide for everything you need to know about urinary tract infections, as well as a treatment to beat antibiotics, which are rapidly becoming ineffective.

We want to make our website as accessible as possible to all readers, regardless of their level of expertise. Words with a dotted blue underline will show a definition when you hover over them.

Project Choice

Approaching the Public

Inspiration for Project

We sent a second questionnaire to find out more about whether the public would use a Solution from synthetic biology to treat Urinary tract infections. We asked more about whether they had heard of genetic engineering or synthetic biology, and how much they trust a recommended treatment by a doctor. In collaboration with UCL, we also filmed some of these responses on the street. The results were overwhelmingly positive.

The Problem

Our Solution

Project Viability

Will Our Idea Work?

Ethics

The UTI Clinic

Delivery Method

Increasing Awareness