Introduction

1. The Harm of Copper

   Copper is a compulsory ingredient in respiratory pigment, and was found in more and more protein and enzyme. On 1847, Harless found that copper has a great action in Molluscs, and on 1878 Frederig first separated copper from protein contamination in blood of octopus, and he named it as ceraloplasim. On 1928,Hart’s report said that copper is a compulsory Element for manual.

   According to study, since copper can effect the absorption of iron, lack of copper will cause Lenkoryfe abnormal, Neutropenia, Osteoporosis and growth retardation, or damage human’s immune system.

   But too much copper will cause harm of human body. It will result in irritation of nose and throat when inhale high concentration of copper. Also it will lead to liver and kidney's damage when intaking high concentration of copper. Copper excession will cause toxicity, including nausea,queasiness, vomit and dirrahea. Other severe symptom like hematuria, jaundice, and urine oligonucleotide may also happen on human beings. Copper poisoning could lead to hemolysis, decrease of hemoglobin and increase of serum lactate dehydrogenase.

2. 相關法規
   • United States
     • 美國環保署要求飲用水中銅濃度不能超過1.3 mg/L。
     • 美國農業部建議八歲以上的人們每天准許含量為900 mg。
     • 美國職業安全及健康管理局(OSHA)要求工作場所中，空氣裡銅的含量不能超過0.1 mg/m3以及含銅的塵土不能超過0.1 mg/m3。
   • Taiwan
     • 飲用水 1.0 ppm
     • Cooking oil 0.4 ppm
     • Egg 5 ppm
     • Drinks 5 ppm

Circuit Design

Just like detecting cadmium , we use the same principle on copper. First, we use the CopA Promoter , which can detect copper and more sensitive than CueO Promoter. When it detects that there is copper in oil, then it will activate the translation reverse.

研究問題與結果

1. 此毒物能否進入ecoli
   1. Method
   2. Result
   3. Discussion
2. 大腸桿菌能否在銅中存活?
   1. Method
   2. Result
   3. Discussion
3. 銅濃度與螢光亮度的關係
   1. Method
   2. Result
   3. Discussion

Reference

• [1]銅與銅中毒 - 中國醫藥大學附設醫院
• [2]《国外医学情报》1996年 第2期 | 张尚文 
• [3]國家環境毒物研究中心
• [4]曹会兰 微量元素与健康研究 2001 年第 18 卷第3期
• [5]台大醫院 衛教資料