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| <div style="position:absolute;text-align:justify;z-index:1;background:none;scroll:scroll-y;left:280px;top:0;margin-top:132px;font-size:13pt;line-height:150%;margin-right:100px;max-width:950px;"> | | <div style="position:absolute;text-align:justify;z-index:1;background:none;scroll:scroll-y;left:280px;top:0;margin-top:132px;font-size:13pt;line-height:150%;margin-right:100px;max-width:950px;"> |
− | <h1>TEXT</h1>
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| + | <h1>Curli</h1> |
| + | <br> |
| + | <h1>Abstract:</h1> |
| <p> | | <p> |
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| + | We want to support the natural functions of our gut and extend its metabolic capacity. This is mediated by a modifiable cell free biofilm matrix which can be modulated according to the need of the user. The system is based on csgA nano fibers and the SpyTag/SpyCatcher system.</p> |
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− | <img src="https://static.igem.org/mediawiki/2015/f/f3/MR_pic_NUTRInitybig.png" class="imgcenter;" style="width:200px;">
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| + | <br> |
− | | + | <h1>Aim:</h1> |
− | <h2>Text</h2> | + | <p> |
− | | + | With our food we take up toxic and unnecessary substances which harm our bodies. In order to prevent these substances to be resorbed by the intestinal mucosa, we wanted to develop a system which converts, reduces or detoxify these components. For these three modes of action we chose <br> |
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| + | a) the lactase for converting lactose into glucose and galactose,<br> |
− | | + | b) the D-galactose/D-glucose binding protein to reduce the natural glucose resorption and <br> |
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| + | c) the alcohol dehydrogenase for detoxification. <br> |
− | | + | To combine these functions we choose a natural occurring biofilm matrix on which we immobilize the corresponding proteins. This platform consists of modified curli fibers which have the capacity to bind proteins via the SypTag/SpyCatcher system. This enables us to design personalized food additives.</p> |
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| + | <br> |
− | | + | <h1>Background:</h1> |
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| + | Curli fibers<br> |
− | | + | Lactase<br> |
− | Consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus.
| + | Alcoholdehydrogenase<br> |
− | | + | D-Galactose-/D-Glucose binding protein<br> |
− | Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.
| + | SpyTag/SpyCatcher system<br> |
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− | Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan et iusto odio dignissim qui blandit praesent luptatum zzril delenit augue duis dolore te feugait nulla facilisi. Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh euismod tincidunt ut laoreet dolore magna aliquam erat volutpat.
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− | Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum. Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh euismod tincidunt ut laoreet dolore magna aliquam erat volutpat. Ut wisi enim ad minim veniam, quis nostrud exerci tation ullamcorper suscipit lobortis nisl ut aliquip ex ea commodo
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− | </p> | + | |
| </div> | | </div> |
| </body> | | </body> |