Difference between revisions of "Team:IIT Delhi/modelling"
| Line 164: | Line 164: | ||
border: 10px solid #003366 ; | border: 10px solid #003366 ; | ||
height:300px; | height:300px; | ||
| − | width: | + | width:500px; |
border-radius:10px 10px 10px 10px; | border-radius:10px 10px 10px 10px; | ||
} | } | ||
| Line 720: | Line 720: | ||
<!-------------------------------footer stuff start---------------------------------------> | <!-------------------------------footer stuff start---------------------------------------> | ||
| − | <footer style="height:20%;background-color:#1E4C7A;position:absolute;margin-top: | + | <footer style="height:20%;background-color:#1E4C7A;position:absolute;margin-top:2000px;width:100%;"> |
<div style="background-color:#1E4C7A;"> | <div style="background-color:#1E4C7A;"> | ||
Revision as of 11:28, 18 September 2015
IntroductionThree of the proteins required in the project are cytochrome c proteins (haem proteins). Hence, the heme biosynthesis pathway needs to be modelled. Pathway of heme production in E. coli (C-5 pathway from glutamate) |
 |
Mathematical modelAlso,d-Aminolevulinate (ALA) produced as an intermediate in the above reactions. -Aminolevulinate Synthase (ALA Synthase) is the committed step of the heme synthesis pathway, and is usually rate-limiting for the overall pathway. Regulation occurs through control of gene transcription. Heme functions as a feedback inhibitor, repressing transcription of the gene for -Aminolevulinate Synthase. |
 |
A non-competitive irreversible feedback inhibition model is assumed for this step with a ki value of 0.02 mM. Hence, the following equation governs the conversion to ALA: |
 |
Click here to read more: |
 |