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| − | {{Descripcion}}
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| − | <html> | + | <h4> Can we base our project on a previous one? </h4> |
| | + | <p>Yes! You can have a project based on a previous team, or based on someone else's idea, <b>as long as you state this fact very clearly and give credit for the original project.</b> </p> |
| | + | </div> |
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| − | <body>
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| − | <div class="gwd-div-wbgu"><span class="gwd-span-3t71"><p class="MsoNormal gwd-p-wkuc"><span class="gwd-span-fn2e">Our project is about </span><span class="gwd-span-a1dh"><span style=""><span lang="EN-US" class="gwd-span-6ea3"><span style="">celiac</span></span>
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| − | </span><span class="gwd-span-xrze"><span lang="EN-US" class="gwd-span-bh3g"> </span><span class="gwd-span-1fs0"><span lang="EN-US" class="gwd-span-5vwr"><span style="">disease, this is a
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| − | enteropathy, autoimmune affecting individuals who possess genes HLA-DQ8 or
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| − | HLA-DQ2, where T cells attack the body when the gliadins and glutenins are
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| − | absorbed by the small intestine, in others words, celiac patients have a
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| − | permanent intolerance to gluten-containing foods</span></span>
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| − | </span><span lang="EN-US" class="gwd-span-1haj">.</span><span lang="EN-US" class="gwd-span-xku1"><o:p></o:p></span></span>
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| − | </span>
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| − | </p>
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| − | <img src="https://2015.igem.org/File:Symptoms_of_celiac_disease.jpg" class="gwd-img-c7yq">
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| − | <div class="gwd-div-6ky8"></div>
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| − | <div class="gwd-div-2b5b"><span class="gwd-span-u82g">The damage caused by the autoimmune reaction can cause histological damage in the villi, and a biopsy of these is the means of diagnosis of this pathology. The only current treatment is a diet without gluten, which is expensive and difficult to follow</span>
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| − | </div>
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| − | <div class="gwd-div-rxi8"><span class="gwd-span-oxe1">This is the tip of the iceberg of celiac disease, the symptoms as are easy to diagnose, but there are other four ways where the symptoms are not so clear. These forms are:<br class="gwd-br-q8fj"></span>
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| − | <ol class="gwd-ol-ewzq">
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| − | <li class="gwd-li-cx4k"><span class="gwd-span-bp36">Silent Celiac Disease: Patients have no symptoms but if damage histological.</span>
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| − | </li>
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| − | <li class="gwd-li-83gw"><span class="gwd-span-y410">Latent Celiac Disease: There are not symptoms and stunted villi. Individuals tend to develop the disease suddenly.</span>
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| − | </li>
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| − | <li class="gwd-li-hrrk"><span class="gwd-span-9f33">Potential Celiac Disease: Are subjects with high genetic risk that could have the disease.</span>
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| − | </li>
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| − | <li class="gwd-li-7d5y"><span class="gwd-span-juom">Refractory Celiac Disease: Those patients diagnosted celiac and despite follow a diet without gluten doesn't improve and can get diseases even more serious.</span>
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| − | </li>
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| − | </ol>
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| − | </div>
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| − | <img src="https://2015.igem.org/File:Iceberg_CD.jpg" class="gwd-img-74jg">
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| − | <div class="gwd-div-nqxo"></div>
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| − | <div class="gwd-div-37ul"><span class="gwd-span-h4j2">The celiac disease are associated with many diseases, these can also be complications of refractory patients.</span>
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| − | </div>
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| − | <img src="https://2015.igem.org/File:Complications.jpg" class="gwd-img-4j8q">
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| − | </span>
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| − | <img src="https://2015.igem.org/File:Enteropatia.jpg" class="gwd-img-tdba">
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| − | <div class="gwd-div-fjcw"></div>
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| − | </div>
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| − | <div class="gwd-div-7fn5"><span class="gwd-span-nj86">When the gluten to come into contact with the villi of the small intestine (enterocytes), the cells helper (type of reporter) detected the gluten like as a toxic substance and leave a footprint chemistry, which is followed by antibodies and lymphocytes T and B. The first are the natural killer and an army of these cells attack the infected cells, which could cause a carcinogen effect, in this case the dangerous cells are the enterocytes, causing inflammation, poor absorption, and other symptoms.</span>
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| − | </div>
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| − | <img src="https://2015.igem.org/File:Histological_study.jpg" class="gwd-img-5j7g">
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| − | <img src="https://2015.igem.org/File:Sin-gluten.jpg" class="gwd-img-24d5">
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| − | </body>
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| | | | |
| | + | <h4> Why is this page needed? </h4> |
| | + | <p>The Attribution requirement helps the judges know what you did yourselves and what you had help with. We don't mind if you get help with difficult or complex techniques, but you must report what work your team did and what work was done by others.</p> |
| | + | <p> |
| | + | For example, you might choose to work with an animal model during your project. Working with animals requires getting a license and applying far in advance to conduct certain experiments in many countries. This is difficult to achieve during the course of a summer, but much easier if you can work with a postdoc or PI who has the right licenses.</p> |
| | + | |
| | + | |
| | + | <h5> What should this page have?</h5> |
| | + | |
| | + | <ul> |
| | + | <li>General Support</li> |
| | + | <li>Project support and advice</li> |
| | + | <li>Fundraising help and advice</li> |
| | + | <li>Lab support</li> |
| | + | <li>Difficult technique support</li> |
| | + | <li>Project advisor support</li> |
| | + | <li>Wiki support</li> |
| | + | <li>Presentation coaching</li> |
| | + | <li>Human Practices support</li> |
| | + | <li> Thanks and acknowledgements for all other people involved in helping make a successful iGEM team</li> |
| | + | </ul> |
| | + | |
| | + | |
| | + | <h4>Inspiration</h4> |
| | + | <p>Take a look at what other teams have done:</p> |
| | + | <ul> |
| | + | <li><a href="https://2011.igem.org/Team:Imperial_College_London/Team">2011 Imperial College London</a> (scroll to the bottom)</li> |
| | + | <li><a href="https://2014.igem.org/Team:Exeter/Attributions">2014 Exeter </a></li> |
| | + | <li><a href="https://2014.igem.org/Team:Melbourne/Attributions">2014 Melbourne </a></li> |
| | + | <li><a href="https://2014.igem.org/Team:Valencia_Biocampus/Attributions">2014 Valencia Biocampus</a></li> |
| | + | </ul> |
| | + | |
| | + | </div> |
| | </html> | | </html> |
The Attribution requirement helps the judges know what you did yourselves and what you had help with. We don't mind if you get help with difficult or complex techniques, but you must report what work your team did and what work was done by others.
For example, you might choose to work with an animal model during your project. Working with animals requires getting a license and applying far in advance to conduct certain experiments in many countries. This is difficult to achieve during the course of a summer, but much easier if you can work with a postdoc or PI who has the right licenses.