Difference between revisions of "Team:SDU-Denmark"

Revision as of 02:25, 19 September 2015

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Introduction

Antibody issue

PAST

Process

Results

Practices

What is Next

Start saving money and animals

PAST (Peptide Aptamer Screening using Two-Hybrid System) is the future

A project focusing on finding an alternative to the traditional antibody production. Currently, all marketed antibodies are made in vitro, by exploiting mammalian cell's immune system and its ability to produce antibodies against a certain antigen. Increasing demands implies the necessity of quicker methods to drive down the costs of production, both because of economical issues and the expense of animal lives. These are exactly the issues that we have been trying to accommodate. Sounds interesting, right? Take a tour through our wiki either by the menu function or the tourmenu. Enjoy!

Medal Requirements

We have been working hard

to accomplish as many medal requirements as possible! Click here to get directed to the requirements page.

Our team

We are the SDU Denmark 2015 team! Click here and get directed to our team page.

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 <h2 class="onBlack">Start saving money and animals</h2>
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-P.A.S.T. (Peptide Aptamer Screening using Two-Hybrid System) is the future
+PAST (Peptide Aptamer Screening using Two-Hybrid System) is the future
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-The nowadays production methods of antibodies are not only time-consuming and costly but are at the expense of animal lives. Antibodies have many applications in research, diagnostics, and show great promise in treatment of cancer. But the advancement is held back due to the expensive and tiresome production. Therefore we propose an alternative to antibodies; peptide aptamers – produced in Escherichia coli (E. coli). The variable loop of the peptide aptamer is generated through a random nucleotide library and held together by an enzymatic inactive version of human Thioredoxin (hThx) as a scaffold protein. We are using the bacterial two-hybrid system to screen for functioning peptide aptamers that are able to bind our chosen target proteins (‘antigens’). In this model bacteria expressing a functioning peptide aptamer will express Red Fluorescent Protein (RFP), which enables us to isolate them. To challenge the antibody tradition, we are also proposing a production model.
+A project focusing on finding an alternative to the traditional antibody production.
+Currently, all marketed antibodies are made in vitro, by exploiting mammalian cell's immune system and its ability to produce antibodies against a certain antigen. Increasing demands implies the necessity of quicker methods to drive down the costs of production, both because of economical issues and the expense of animal lives. These are exactly the issues that we have been trying to accommodate. Sounds interesting, right? Take a tour through our wiki either by the menu function or the tourmenu. Enjoy!
      </p>
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