Difference between revisions of "Team:SDU-Denmark/Tour12"

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<li> <b>Robert William Naur</b> for proof reading on The Little Curios Story about the Curios Little Being</li>
 
<li> <b>Robert William Naur</b> for proof reading on The Little Curios Story about the Curios Little Being</li>
 
<li> <b>Anna Valgreen</b> for providing the illustrations, The Curios Little Story about a Curious Little Being</li>
 
<li> <b>Anna Valgreen</b> for providing the illustrations, The Curios Little Story about a Curious Little Being</li>
 +
<li> <b>Torben Hansson</b>, Associated Professor, Institude of Chemical Engineering, Biotechnology and Enviromental Technology - for helping us with the Process Flow Diagram.</li>
 +
<li> <b>Knud Villy Christensen, Associate Professor, MSc. Chem. Eng. PhD in Chem. Eng. - for helping advice on the Process Flow Diagram.</li>
 
</ul>  
 
</ul>  
  
Line 52: Line 54:
 
<h2>Litterature support</h2>
 
<h2>Litterature support</h2>
  
−
<p> <span class="intro"> Antibody issue </span></p>
+
<p><span class="intro"> Antibody issue</span></p>
−
<ul>  
+
<ul>
−
<li> Lubert Stryer JMB, John L. Tymoczko. The Immune System.  Biochemistry. 7 ed: W. H. Freeman and Company; 2012. </li>
+
 
−
<li> Cowan MK. Host Defenses II - Specific Immunity and Immunization.  Microbiology - A Systems Approach. 3 ed: McGraw-Hill; 2012. </li>
+
<li>Liu JK1 (2014) The history of monoclonal antibody development - Progress, remaining challenges and future innovations.
−
<li> Chippaux JP, Goyffon M. Venoms, antivenoms and immunotherapy. Toxicon. 1998;36(6):823-46. </li>
+
 
−
<li> Clem AS. Fundamentals of vaccine immunology. J Glob Infect Dis. 2011;3(1):73-8. </li>
+
Sep 11;3(4):113-6. DOI: 10.1016/j.amsu.2014.09.001.<a
−
<li> Siddiqui MZ. Monoclonal antibodies as diagnostics; an appraisal. Indian J Pharm Sci. 2010;72(1):12-7. </li>
+
 
−
<li> Berger M, Shankar V, Vafai A. Therapeutic applications of monoclonal antibodies. Am J Med Sci. 2002;324(1):14-30. </li>
+
target="_blank"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284445/"> (LINK) </a></li>
−
<li> Scott AM, Wolchok JD, Old LJ. Antibody therapy of cancer. Nat Rev Cancer. 2012;12(4):278-87. </li>
+
 
−
<li> BioPharma P. What Are Humanized Monoclonal Antibodies 2015 [cited 2015 08/08]. <a target="_blank" href="http://pdl.com/technology-products/what-are-humanized-monoclonal-antibodies/">(Link)</a> </li>
+
<li>Dawn M Ecker, Susan Dana Jones & Howard L Levine (2015) The therapeutic monoclonal antibody market, mAbs, 7:1, 9-14,
−
<li> Payne WJ, Jr., Marshall DL, Shockley RK, Martin WJ. Clinical laboratory applications of monoclonal antibodies. Clin Microbiol Rev. 1988;1(3):313-29. </li>
+
 
−
<li> Hnasko RM, Stanker LH. Hybridoma Technology. Methods Mol Biol. 2015;1318:15-28. </li>
+
DOI: 10.4161/19420862.2015.989042.<a target="_blank"LINK"> (LINK) </a>
−
<li> Stills HF, Jr. Adjuvants and antibody production: dispelling the myths associated with Freund's complete and other adjuvants. ILAR journal / National Research Council, Institute of Laboratory Animal Resources. 2005;46(3):280-93. </li>  
+
LINK: http://dx.doi.org/10.4161/19420862.2015.989042</li>
−
<li> Chames P, Van Regenmortel M, Weiss E, Baty D. Therapeutic antibodies: successes, limitations and hopes for the future. Br J Pharmocol. 2009;157(2):220-33. </li>
+
 
−
<li> Descartes Rene. Les Méditations métaphysiques’, 1647 </li>
+
<li>Lubert Stryer JMB, John L. Tymoczko. The Immune System.  Biochemistry. 7 ed: W. H. Freeman and Company; 2012.</li>
−
<li> Bentham Jeremy, Introduction to the Principles of Morals and Legislation, 1789 </li>
+
 
−
<li> Three RS <a target="_blank" href="http://3rs.ccac.ca/en/">(Link)</a> </li>
+
<li>Cowan MK. Host Defenses II - Specific Immunity and Immunization.  Microbiology - A Systems Approach. 3 ed: McGraw-
−
<li> Cruelty Free International <a target="_blank" href="https://www.crueltyfreeinternational.org/">(Link)</a> </li>
+
 
−
<li> Nelson PN, Reynolds GM, Waldron EE, Ward E, Giannopoulos K, Murray PG. Demystified …: Monoclonal antibodies. Molecular Pathology. 2000;53(3):111-7. </li>
+
Hill; 2012.</li>
−
<li> Colas P. The eleven-year switch of peptide aptamers. Journal of biology. 2008;7(1):2. </li>
+
 
−
<li> Colas P, Cohen B, Jessen T, Grishina I, McCoy J, Brent R. Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2. Nature. 1996;380(6574):548-50. </li>
+
<li>Chippaux JP, Goyffon M. Venoms, antivenoms and immunotherapy. Toxicon. 1998;36(6):823-46.</li>
−
<li> Borghouts C, Kunz C, Delis N, Groner B. Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition. Molecular cancer research : MCR. 2008;6(2):267-81. </li>
+
 
−
<li> Evans D, Johnson S, Laurenson S, Davies AG, Ko Ferrigno P, Wälti C. Electrical protein detection in cell lysates using high-density peptide-aptamer microarrays. Journal of biology. 2008;7(1):3. </li>
+
<li>Clem AS. Fundamentals of vaccine immunology. J Glob Infect Dis. 2011;3(1):73-8.</li>
−
<li> Li J, Tan S, Chen X, Zhang CY, Zhang Y. Peptide aptamers with biological and therapeutic applications. Current medicinal chemistry. 2011;18(27):4215-22. </li>
+
 
−
<li> Swiss Institute of Bioinformatics. 2015. <a target="_blank" href="http://web.expasy.org/cgi-bin/protparam/protparam1?P10599%402-105"> (Link)</a> </li>
+
<li>Siddiqui MZ. Monoclonal antibodies as diagnostics; an appraisal. Indian J Pharm Sci. 2010;72(1):12-7.</li>
−
<li> Key Benefits: Affimers have some simple but essential advantages over antibodies: Avacta Life Sciences;  [updated 19-08-2015]. <a target="_blank" href="https://www.avactalifesciences.com/key-benefits"> (Link)</a> </li>
+
 
 +
<li>Berger M, Shankar V, Vafai A. Therapeutic applications of monoclonal antibodies. Am J Med Sci. 2002;324(1):14-30.</li>
 +
 
 +
<li>Payne WJ, Jr., Marshall DL, Shockley RK, Martin WJ. Clinical laboratory applications of monoclonal antibodies. Clin  
 +
 
 +
Microbiol Rev. 1988;1(3):313-29.</li>
 +
 
 +
<li>Hnasko RM, Stanker LH. Hybridoma Technology. Methods Mol Biol. 2015;1318:15-28.</li>
 +
 
 +
<li>Stills HF, Jr. Adjuvants and antibody production: dispelling the myths associated with Freund's complete and other  
 +
 
 +
adjuvants. ILAR journal / National Research Council, Institute of Laboratory Animal Resources. 2005;46(3):280-93.</li>
 +
 
 +
<li>Rene Descartes, Meditationer over den første filosofi. Publisher: Det Lille Forlag 1. edition, published
 +
 
 +
19.04.2002.</li>
 +
 
 +
<li>Jeremy Bentham, An Introduction to the Principles of Morals and Legislation (General Historical Collections).
 +
 
 +
Publisher: British Library, Historical Print Editions. Published 25.03.2011</li>
 +
 
 +
<li>Good Animal Practise in Science. Visited: 04.09.15.<a target="_blank"http://3rs.ccac.ca/en/"> (LINK) </a></li>
 +
 
 +
<li>Cruelty Free International. Visited 04.09.15.<a target="_blank"https://www.crueltyfreeinternational.org/"> (LINK)  
 +
 
 +
</a></li>
 +
 
 +
<li>Colas P. The eleven-year switch of peptide aptamers. Journal of biology. 2008;7(1):2.</li>
 +
 
 +
<li>Borghouts C, Kunz C, Delis N, Groner B. Monomeric recombinant peptide aptamers are required for efficient  
 +
 
 +
intracellular uptake and target inhibition. Molecular cancer research : MCR. 2008;6(2):267-81.</li>
 +
 
 +
<li>Evans D, Johnson S, Laurenson S, Davies AG, Ko Ferrigno P, Wälti C. Electrical protein detection in cell lysates using  
 +
 
 +
high-density peptide-aptamer microarrays. Journal of biology. 2008;7(1):3.</li>
 +
 
 +
<li>Li J, Tan S, Chen X, Zhang CY, Zhang Y. Peptide aptamers with biological and therapeutic applications. Current  
 +
 
 +
medicinal chemistry. 2011;18(27):4215-22.</li>
 +
 
 +
<li>Swiss Institute of Bioinformatics. 2015.<a target="_blank"http://web.expasy.org/cgi-bin/protparam/protparam1?
 +
 
 +
P10599%402-105"> (LINK) </a></li>
 +
 
 +
<li>Key Benefits: Affimers have some simple but essential advantages over antibodies: Avacta Life Sciences;  [updated 19-
 +
 
 +
08-2015].<a target="_blank"https://www.avactalifesciences.com/key-benefits"> (LINK) </a></li>
  
 
</ul>
 
</ul>
Line 83: Line 132:
 
<ul>
 
<ul>
  
−
<li>Karimova G, Pidoux J, Ullmann A, Ladant D. A bacterial two-hybrid system based on a reconstituted signal transduction pathway. Proceedings of the National Academy of Sciences of the United States of America. 1998;95(10):5752-6.<a target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC20451/">(Link)</a></li>
+
<li>Karimova G, Pidoux J, Ullmann A, Ladant D. (1998) A bacterial two-hybrid system based on a reconstituted signal  
  
−
<li>Battesti A, Bouveret E. The bacterial two-hybrid system based on adenylate cyclase reconstitution in Escherichia coli. Methods (San Diego, Calif). 2012;58(4):325-34.<a target="_blank" href="http://www.sciencedirect.com/science/article/pii/S1046202312001740">(Link)</a></li>
+
transduction pathway. 1998;95(10):5752-6.<a target="_blank"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC20451/"> (LINK)  
  
−
<li>SIMON L. DOVE, J. KEITH JOUNG* & ANN HOCHSCHILD - ‘Activation of prokaryotic transcription through arbitrary protein–protein contacts’ - Nature 386, 627-630 (10 April 1997).<a target="_blank" href="http://www.nature.com/nature/journal/v386/n6625/pdf/386627a0.pdf">(Link)</a></li>
+
</a></li>
  
−
<li>J. Keith Joung, Elizabeth I. Ramm, and Carl O. Pabo - ‘A bacterial two-hybrid selection system for studying protein–DNA and protein–protein interactions’ - Proceedings of the National Academy of Science of the United States. vol. 97, (20 june 2000).<a target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC16554/">(Link)</a></li>
+
<li>Battesti A, Bouveret E. (2012) The bacterial two-hybrid system based on adenylate cyclase reconstitution in
−
</ul>
+
  
 +
Escherichia coli. 2012;58(4):325-34. DOI:10.1016/j.ymeth.2012.07.018.<a
 +
 +
target="_blank"http://www.sciencedirect.com/science/article/pii/S1046202312001740"> (LINK) </a></li>
 +
 +
<li>SIMON L. DOVE, J. KEITH JOUNG* & ANN HOCHSCHILD. (1997) Activation of prokaryotic transcription through arbitrary
 +
 +
protein–protein contacts. Nature 386, 627-630 (10 April 1997).<a
 +
 +
target="_blank"http://www.nature.com/nature/journal/v386/n6625/pdf/386627a0.pdf"> (LINK) </a></li>
 +
 +
<li>J. Keith Joung, Elizabeth I. Ramm, and Carl O. Pabo (2000) A bacterial two-hybrid selection system for studying
 +
 +
protein–DNA and protein–protein interactions. PNAS. US. vol. 97, (20 june 2000).<a
 +
 +
target="_blank"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC16554/"> (LINK) </a></li>
 +
 +
<li>Lutz R, Bujard H. Independent and tight regulation of transcriptional units in <i>Escherichia coli</i> via the LacR/O,
 +
 +
the TetR/O and AraC/I1-I2 regulatory elements. Nucleic Acids Res. 1997 Mar 15;25(6):1203-10.<a
 +
 +
target="_blank"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC146584"> (LINK) </a></li>
 +
 +
<li>Borghouts C, Kunz C, Delis N, Groner B. Monomeric Recombinant Peptide Aptamers Are Required for Efficient
 +
 +
Intracellular Uptake and Target Inhibition. Molecular Cancer Research. 2008;6(2):267-81.<a
 +
 +
target="_blank"http://mcr.aacrjournals.org/content/6/2/267.long"> (LINK) </a></li>
 +
 +
<li>Sigmar-Aldrich: 3xFLAG system. Visited: 16.09.15.<a target="_blank"http://www.sigmaaldrich.com/life-
 +
 +
science/molecular-biology/cloning-and-expression/vector-systems/mat-system-vectors/3x-flag.html#Figure 1"> (LINK)
 +
 +
</a></li>
 +
 +
<li>Seider, Seader, Lewin and Widagoo. Product and Process Design Principles - Synthesis, Analysis, and Evaluation; Third
 +
 +
Edition - International Student Version; John Wiley & Sons, Inc.; 2010</li>
 +
 +
<li>Available at: https://www.sigmaaldrich.com/denmark.html [accessed: 10.09.2015]</li>
 +
 +
<li>Available at: https://www.neb.com/products/e8036-chitin-magnetic-beads [accessed: 13.09.2015]</li>
 +
 +
<li>Available at: http://www.rand.org/content/dam/rand/pubs/monograph_reports/MR1325/MR1325.ch9.pdf [accessed:
 +
 +
15.09.2015]</li>
 +
 +
<li>Sigma-Aldrich. Available at: http://www.sigmaaldrich.com/catalog/product/sigma/a2220?lang=en&region=DK [Accessed 1st
 +
 +
august 2015]</li>
 +
 +
<li>L. Yee and H. W. Blanch. Recombinant Trypsin Production in High Cell Density Fed-Batch Cultures in Escherichia coli.
 +
 +
Biotechnology and Bioengineering. 1993; 41: 781-790</li>
 +
 +
<li>Michael L. Shuler and Fikret Kargi. Bioprocess Engineering - Basic Concepts; second edition; Pearson Education
 +
 +
International; 2002</li>
 +
 +
<li>IMPACT™ Kit. 2015. New England Biolabs; [accessed 2015 Sep 11]<a target="_blank"https://www.neb.com/products/e6901-
 +
 +
impact-kit"> (LINK) </a></li>
 +
 +
<li>Pharmacia. Introduction to Expanded Bed Adsorption.<a
 +
 +
target="_blank"http://wolfson.huji.ac.il/purification/PDF/Expanded_Bed_Absorption/PHARMACIA_IntrodEBA.pdf"> (LINK)
 +
 +
</a></li>
 +
 +
<li>Sigma-Aldrich.<a target="_blank"http://www.sigmaaldrich.com/catalog/search?interface=All&term=antibodies
 +
 +
+monoclonal&N=0+14574647&mode=match+partialmax&focus=product&lang=en&region=DK"> (LINK) </a></li>
 +
 +
<li>jeffrey Fu, David B. Wilson and Michael L. Shuler. Continuous, High Level Production and Excretion of a Plasmid-
 +
 +
Encoded Protein by Escherichia coli in a Two-Stage Chemostat. Biotechnology and Bioengineering, 1993; 41: 937-946</li>
 +
 +
</ul>
 
<p> <span class="intro">Process </span></p>
 
<p> <span class="intro">Process </span></p>
 
<ul>
 
<ul>
−
<li>World health organization, third edition, 2004 - Visited: 16.09.15.<a target="_blank" href="http://www.who.int/csr/resources/publications/biosafety/en/Biosafety7.pdf?ua=1">(Link)</a></li>
 
−
<li>Lov om miljø og genteknologi - Visited: 16.09.15.<a target="_blank" href="https://www.retsinformation.dk/Forms/R0710.aspx?id=132155">(Link)</a></li>
 
−
<li>Arbejdstilsynet - Visited: 16.09.15.<a target="_blank" href="http://arbejdstilsynet.dk/da/regler/at-vejledninger/k/c-0-4-klassifikation-af-laboratorier.aspx">(Link)</a></li>
 
−
<li>E.coli Genome Project, University of Wisconsin - Visited: 16.09.15.<a target="_blank" href="http://www.genome.wisc.edu/resources/strains.htm">(Link)</a></li>
 
−
<li>NIH Guidelines for research involving - Visited: 16.09.15.<a target="_blank" href="http://osp.od.nih.gov/sites/default/files/NIH_Guidelines.html#_Toc351276292">(Link)</a></li>
 
−
<li>WO 2001073108 A2 - Patent - Visited: 16.09.15.<a target="_blank" href="http://www.google.com/patents/WO2001073108A2?hl=da&cl=en">(Link)</a></li>
 
−
<li>Europa-parlementets og rådets direktiv 2009/41/EF - Visited: 16.09.15.<a target="_blank" href="http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2009:125:0075:0097:DA:PDF
 
−
">(Link)</a></li>
 
−
</ul>
 
  
 +
<li>World health organization, third edition, 2004 - Visited: 16.09.15.<a
 +
 +
target="_blank"http://www.who.int/csr/resources/publications/biosafety/en/Biosafety7.pdf?ua=1"> (LINK) </a></li>
 +
 +
<li>Arbejdstilsynet - Visited: 16.09.15.<a target="_blank"http://arbejdstilsynet.dk/da/regler/at-vejledninger/k/c-0-4-
 +
 +
klassifikation-af-laboratorier.aspx"> (LINK) </a></li>
 +
 +
<li>Lov om miljø og genteknologi - Visited: 16.09.15.<a target="_blank"https://www.retsinformation.dk/Forms/R0710.aspx?
 +
 +
id=132155"> (LINK) </a></li>
 +
 +
<li>E.coli Genome Project, University of Wisconsin - Visited: 16.09.15.<a
 +
 +
target="_blank"http://www.genome.wisc.edu/resources/strains.htm"> (LINK) </a></li>
 +
 +
<li>WO 2001073108 A2 - Patent - Visited: 16.09.15.<a target="_blank"http://www.google.com/patents/WO2001073108A2?
 +
 +
hl=da&cl=en"> (LINK) </a></li>
 +
 +
<li>The EU-parliaments directive 2009/41/EF - Visited: 16.09.15.<a target="_blank"http://eur-
 +
 +
lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2009:125:0075:0097:DA:PDF"> (LINK) </a></li>
 +
 +
</ul>
 
<p> <span class="intro">Results </span></p>
 
<p> <span class="intro">Results </span></p>
 +
<ul>
 +
 +
<li>One Shot® Top10 Chemically Competent E. coli. Catalog number: C4040-10. Visited: 17.09.15.<a
 +
 +
target="_blank"https://www.thermofisher.com/order/catalog/product/C404010"> (LINK) </a></li>
 +
 +
<li>Kate B. Bechtol, David K. Hanzel, and Bee Choo Liang, Amersham Biosciences, Inc. - Understanding Fluorescence.<a
 +
 +
target="_blank"https://www.gelifesciences.com/gehcls_images/GELS/Related
 +
 +
%20Content/Files/1314729545976/litdoc63002879_20110830221802.pdf"> (LINK) </a></li>
 +
 +
<li>iGEM Parts Registry - BBa_J23119:Design. Visited: 17.09.15.<a
 +
 +
target="_blank"http://parts.igem.org/Part:BBa_J23119:Design"> (LINK) </a></li>
 +
 +
<li>JCAnderson. iGEM Parts Registry - Visited: 17.09.15.<a target="_blank"http://parts.igem.org/File:PBca1020-r0040.jpg">
 +
 +
(LINK) </a></li>
 +
 +
<li>Brendan P. Cormack, Raphael H. Valdiviaa, Stanley Falkow - FACS-optimized mutants of the green fluorescent protein
 +
 +
(GFP). DOI:10.1016/0378-1119(95)00685-0.<a
 +
 +
target="_blank"http://www.sciencedirect.com/science/article/pii/0378111995006850"> (LINK) </a></li>
 +
 +
</ul>
 
<p> <span class="intro"> Practices </span></p>
 
<p> <span class="intro"> Practices </span></p>
−
<ul>  
+
<ul>
 +
 
 +
<li>Jürgen Habermas, Diskurs Etik. Publisher: Det Lille Forlag, 1. edition, published 02.09.1998. <br>ISBN-13:
 +
 
 +
9788790030445</li>
  
 
</ul>
 
</ul>
 
<p> <span class="intro"> What's Next </span></p>
 
<p> <span class="intro"> What's Next </span></p>
 
<ul>
 
<ul>
−
<li>Karimova G, Pidoux J, Ullmann A, Ladant D. - A bacterial two-hybrid system based on a reconstituted signal transduction pathway. Proceedings of the National Academy of Sciences of the United States of America. 1998;95(10):5752-6.<a target="_blank" href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC20451/">(Link)</a></li></li>
+
 
 +
<li>Kim CS, et al. Cellular imaging of endosome entrapped small gold nanoparticles, 2015 Jun 10;2:306-15. doi:
 +
 
 +
10.1016/j.mex.2015.06.001.<a target="_blank"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487928/"> (LINK) </a></li>
 +
 
 +
<li>Thorek DL et al. Reverse-Contrast Imaging and Targeted Radiation Therapy of Advanced Pancreatic Cancer Models. Int J
 +
 
 +
Radiat Oncol Biol Phys. 2015 Jun 9. pii: S0360-3016(15)00612-4. DOI:10.1016/j.ijrobp.2015.06.001.<a  
 +
 
 +
target="_blank"http://www.ncbi.nlm.nih.gov/pubmed/26238952"> (LINK) </a></li>
 +
 
 +
<li>Wacker M et al. N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli. Science. 2002
 +
 
 +
Nov 29;298(5599):1790-3.<a target="_blank"http://www.ncbi.nlm.nih.gov/pubmed/12459590"> (LINK) </a></li>
 +
 
 +
<li>Silberstein S, Lenz R, Xu C. Therapeutic Monoclonal Antibodies: What Headache Specialists Need to Know. Headache. 2015
 +
 
 +
Aug 28. DOI: 10.1111/head.12642.<a target="_blank"http://www.ncbi.nlm.nih.gov/pubmed/26316307"> (LINK) </a></li>
 +
 
 +
<li>Technical Guide for ELISA. Available from KPL, Kirkegaard & Perry Laboratories.<a
 +
 
 +
target="_blank"http://www.kpl.com/docs/techdocs/KPL%20ELISA%20Technical%20Guide.pdf"> (LINK) </a></li>
 +
 
 +
<li>An Introduction to BiaCore's SPR Technology. Available from BiaCore.com.<a
 +
 
 +
target="_blank"http://www.rci.rutgers.edu/~longhu/Biacore/pdf_files/SPR_Technology_Brochure.pdf"> (LINK) </a></li>
 +
 
 +
<li>Open WetWare contributors, "Beta-Galactosidase Assay (A better Miller)," <i>Open WetWare</i>27 August 2012, 23:20
 +
 
 +
UTC.<a target="_blank"http://openwetware.org/wiki/Beta-Galactosidase_Assay_(A_better_Miller)"> (LINK) </a></li>
 +
 
 
</ul>
 
</ul>
 +
  
 
</html>
 
</html>
  
 
{{:Team:SDU-Denmark/core/footer}}
 
{{:Team:SDU-Denmark/core/footer}}

Revision as of 03:33, 19 September 2015

iGEM logo
Introduction
Antibody issue
PAST
Process
Results
Practices
What is Next

"The next best thing to knowing something is knowing where to find it." - Samuel Johnson

Attributions

Despite our tireless efforts we could not have done this on our own. Therefore we would like to express our gratitude and thank all.

Sponsors

Laboratory support

  • Our instructors Postdoc and Ph. D. Mikkel Girke Jørgensen, Academic Assistant Tina Kronborg, Ph. D. student Thøger Jensen Krogh and Stud.cand.scient Patrick Rosendahl Andreassen
  • Medical Laboratory Technician Simon Rose who provided a security course
  • Postdoc Anders Boysen helped with troubleshooting in the lab

General support

  • DTU iGEM team – for arranging the anually bio brick workshop
  • Vilnius iGEM team for hosting our visit for three days
  • Uppsala iGEM team for arranging and hosting the Nordic Meetup
  • Associate Professor, MD Søren Thue Lillevang, Department of Clinical Immunology, Odense University Hospital, for attributing to the discussion about medical aspects
  • Associate Professor Jan Nehlin, Department of Clinical Immunology, Odense University Hospital, for discussing patents and medical aspects, and suggestions to future work
  • Nancy Rasmussen for helping us proof reading our wiki
  • Members of the previous SDU-Denmark iGEM teams for giving feedback on our presentation and cooking for us
  • Robert William Naur for proof reading on The Little Curios Story about the Curios Little Being
  • Anna Valgreen for providing the illustrations, The Curios Little Story about a Curious Little Being
  • Torben Hansson, Associated Professor, Institude of Chemical Engineering, Biotechnology and Enviromental Technology - for helping us with the Process Flow Diagram.
  • Knud Villy Christensen, Associate Professor, MSc. Chem. Eng. PhD in Chem. Eng. - for helping advice on the Process Flow Diagram.

Technical support

  • Ph. D. Thøger Jensen Krogh helped us with any problem regarding our wiki site.
  • The SDU iGEM team 2013 for helping us with our wiki.

Litterature support

Antibody issue

  • Liu JK1 (2014) The history of monoclonal antibody development - Progress, remaining challenges and future innovations. Sep 11;3(4):113-6. DOI: 10.1016/j.amsu.2014.09.001. (LINK)
  • Dawn M Ecker, Susan Dana Jones & Howard L Levine (2015) The therapeutic monoclonal antibody market, mAbs, 7:1, 9-14, DOI: 10.4161/19420862.2015.989042. (LINK) LINK: http://dx.doi.org/10.4161/19420862.2015.989042
  • Lubert Stryer JMB, John L. Tymoczko. The Immune System. Biochemistry. 7 ed: W. H. Freeman and Company; 2012.
  • Cowan MK. Host Defenses II - Specific Immunity and Immunization. Microbiology - A Systems Approach. 3 ed: McGraw- Hill; 2012.
  • Chippaux JP, Goyffon M. Venoms, antivenoms and immunotherapy. Toxicon. 1998;36(6):823-46.
  • Clem AS. Fundamentals of vaccine immunology. J Glob Infect Dis. 2011;3(1):73-8.
  • Siddiqui MZ. Monoclonal antibodies as diagnostics; an appraisal. Indian J Pharm Sci. 2010;72(1):12-7.
  • Berger M, Shankar V, Vafai A. Therapeutic applications of monoclonal antibodies. Am J Med Sci. 2002;324(1):14-30.
  • Payne WJ, Jr., Marshall DL, Shockley RK, Martin WJ. Clinical laboratory applications of monoclonal antibodies. Clin Microbiol Rev. 1988;1(3):313-29.
  • Hnasko RM, Stanker LH. Hybridoma Technology. Methods Mol Biol. 2015;1318:15-28.
  • Stills HF, Jr. Adjuvants and antibody production: dispelling the myths associated with Freund's complete and other adjuvants. ILAR journal / National Research Council, Institute of Laboratory Animal Resources. 2005;46(3):280-93.
  • Rene Descartes, Meditationer over den første filosofi. Publisher: Det Lille Forlag 1. edition, published 19.04.2002.
  • Jeremy Bentham, An Introduction to the Principles of Morals and Legislation (General Historical Collections). Publisher: British Library, Historical Print Editions. Published 25.03.2011
  • Good Animal Practise in Science. Visited: 04.09.15. (LINK)
  • Cruelty Free International. Visited 04.09.15. (LINK)
  • Colas P. The eleven-year switch of peptide aptamers. Journal of biology. 2008;7(1):2.
  • Borghouts C, Kunz C, Delis N, Groner B. Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition. Molecular cancer research : MCR. 2008;6(2):267-81.
  • Evans D, Johnson S, Laurenson S, Davies AG, Ko Ferrigno P, Wälti C. Electrical protein detection in cell lysates using high-density peptide-aptamer microarrays. Journal of biology. 2008;7(1):3.
  • Li J, Tan S, Chen X, Zhang CY, Zhang Y. Peptide aptamers with biological and therapeutic applications. Current medicinal chemistry. 2011;18(27):4215-22.
  • Swiss Institute of Bioinformatics. 2015. (LINK)
  • Key Benefits: Affimers have some simple but essential advantages over antibodies: Avacta Life Sciences; [updated 19- 08-2015]. (LINK)

PAST

  • Karimova G, Pidoux J, Ullmann A, Ladant D. (1998) A bacterial two-hybrid system based on a reconstituted signal transduction pathway. 1998;95(10):5752-6. (LINK)
  • Battesti A, Bouveret E. (2012) The bacterial two-hybrid system based on adenylate cyclase reconstitution in Escherichia coli. 2012;58(4):325-34. DOI:10.1016/j.ymeth.2012.07.018. (LINK)
  • SIMON L. DOVE, J. KEITH JOUNG* & ANN HOCHSCHILD. (1997) Activation of prokaryotic transcription through arbitrary protein–protein contacts. Nature 386, 627-630 (10 April 1997). (LINK)
  • J. Keith Joung, Elizabeth I. Ramm, and Carl O. Pabo (2000) A bacterial two-hybrid selection system for studying protein–DNA and protein–protein interactions. PNAS. US. vol. 97, (20 june 2000). (LINK)
  • Lutz R, Bujard H. Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements. Nucleic Acids Res. 1997 Mar 15;25(6):1203-10. (LINK)
  • Borghouts C, Kunz C, Delis N, Groner B. Monomeric Recombinant Peptide Aptamers Are Required for Efficient Intracellular Uptake and Target Inhibition. Molecular Cancer Research. 2008;6(2):267-81. (LINK)
  • Sigmar-Aldrich: 3xFLAG system. Visited: 16.09.15. (LINK)
  • Seider, Seader, Lewin and Widagoo. Product and Process Design Principles - Synthesis, Analysis, and Evaluation; Third Edition - International Student Version; John Wiley & Sons, Inc.; 2010
  • Available at: https://www.sigmaaldrich.com/denmark.html [accessed: 10.09.2015]
  • Available at: https://www.neb.com/products/e8036-chitin-magnetic-beads [accessed: 13.09.2015]
  • Available at: http://www.rand.org/content/dam/rand/pubs/monograph_reports/MR1325/MR1325.ch9.pdf [accessed: 15.09.2015]
  • Sigma-Aldrich. Available at: http://www.sigmaaldrich.com/catalog/product/sigma/a2220?lang=en&region=DK [Accessed 1st august 2015]
  • L. Yee and H. W. Blanch. Recombinant Trypsin Production in High Cell Density Fed-Batch Cultures in Escherichia coli. Biotechnology and Bioengineering. 1993; 41: 781-790
  • Michael L. Shuler and Fikret Kargi. Bioprocess Engineering - Basic Concepts; second edition; Pearson Education International; 2002
  • IMPACT™ Kit. 2015. New England Biolabs; [accessed 2015 Sep 11] (LINK)
  • Pharmacia. Introduction to Expanded Bed Adsorption. (LINK)
  • Sigma-Aldrich. (LINK)
  • jeffrey Fu, David B. Wilson and Michael L. Shuler. Continuous, High Level Production and Excretion of a Plasmid- Encoded Protein by Escherichia coli in a Two-Stage Chemostat. Biotechnology and Bioengineering, 1993; 41: 937-946

Process

  • World health organization, third edition, 2004 - Visited: 16.09.15. (LINK)
  • Arbejdstilsynet - Visited: 16.09.15. (LINK)
  • Lov om miljø og genteknologi - Visited: 16.09.15. (LINK)
  • E.coli Genome Project, University of Wisconsin - Visited: 16.09.15. (LINK)
  • WO 2001073108 A2 - Patent - Visited: 16.09.15. (LINK)
  • The EU-parliaments directive 2009/41/EF - Visited: 16.09.15. (LINK)

Results

  • One Shot® Top10 Chemically Competent E. coli. Catalog number: C4040-10. Visited: 17.09.15. (LINK)
  • Kate B. Bechtol, David K. Hanzel, and Bee Choo Liang, Amersham Biosciences, Inc. - Understanding Fluorescence. (LINK)
  • iGEM Parts Registry - BBa_J23119:Design. Visited: 17.09.15. (LINK)
  • JCAnderson. iGEM Parts Registry - Visited: 17.09.15. (LINK)
  • Brendan P. Cormack, Raphael H. Valdiviaa, Stanley Falkow - FACS-optimized mutants of the green fluorescent protein (GFP). DOI:10.1016/0378-1119(95)00685-0. (LINK)

Practices

  • Jürgen Habermas, Diskurs Etik. Publisher: Det Lille Forlag, 1. edition, published 02.09.1998.
    ISBN-13: 9788790030445

What's Next

  • Kim CS, et al. Cellular imaging of endosome entrapped small gold nanoparticles, 2015 Jun 10;2:306-15. doi: 10.1016/j.mex.2015.06.001. (LINK)
  • Thorek DL et al. Reverse-Contrast Imaging and Targeted Radiation Therapy of Advanced Pancreatic Cancer Models. Int J Radiat Oncol Biol Phys. 2015 Jun 9. pii: S0360-3016(15)00612-4. DOI:10.1016/j.ijrobp.2015.06.001. (LINK)
  • Wacker M et al. N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli. Science. 2002 Nov 29;298(5599):1790-3. (LINK)
  • Silberstein S, Lenz R, Xu C. Therapeutic Monoclonal Antibodies: What Headache Specialists Need to Know. Headache. 2015 Aug 28. DOI: 10.1111/head.12642. (LINK)
  • Technical Guide for ELISA. Available from KPL, Kirkegaard & Perry Laboratories. (LINK)
  • An Introduction to BiaCore's SPR Technology. Available from BiaCore.com. (LINK)
  • Open WetWare contributors, "Beta-Galactosidase Assay (A better Miller)," Open WetWare27 August 2012, 23:20 UTC. (LINK)

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