Difference between revisions of "Team:Marburg"

(Prototype team page)
 
Line 1: Line 1:
{{Marburg}}
+
<html>
<html>
+
<h2> Welcome to iGEM 2015! </h2>
+
<p>Your team has been approved and you are ready to start the iGEM season! </p>
+
  
<h4>Before you start: </h4>
+
<h1 style="color:green"><center>
<p> Please read the following pages:</p>
+
This page is in progress!
<ul>
+
</center></h1>
<li>  <a href="https://2015.igem.org/Requirements">Requirements page </a> </li>
+
<li> <a href="https://2015.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
+
</ul>
+
  
<div class="highlightBox">
+
<h2 style="font-size:150%">
<h4> Styling your wiki </h4>
+
Our Projects:
<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
+
</h2>
<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
+
</div>
+
  
<h4> Editing your wiki </h4>
+
<body>
<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
+
<h2>Curli fibres</h2>
<p> <a href="https://2015.igem.org/wiki/index.php?title=Team:Marburg&action=edit"> Click here to edit this page! </a></p>
+
<p>
<p>See tips on how to edit your wiki on the <a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation</a> page.</p>
+
Our main goal is to produce new nutrition out of agrar-culture waste. Therefore we combined the best features of chemistry and biology for the degradation of cellulose to glucose. In this regard, we took the chemical degration of cellulose via phosphoric acid and combined it with the biological way of storing it in a stable hydroxylapatite matrix. This matrix is build up of modified curli fibres, on which the hydroxylapatite crystalized out and can be reactivated by lacto bacillus. This system is an enclosed cellulose capsule, which maintains a high and stable phosphoric acid concentration. Through the high and local concentration of phosphoric acid the surrounding cellulose gets efficiently degraded. Main advantages are that the phosphoric acid can be handled safely.
 
+
</p><br>
 
+
<h2>Synthetic Chromosome and Minicells</h2>
<h4>Templates </h4>
+
<p>
<p> This year we have created templates for teams to use freely. More information on how to use and edit the templates can be found on the
+
The Synthetic Chromosome is derived form the secondary Chromosome of Vibrio Cholerae. The structure and stability of this genetic element opens up the possibility of adding a lot of genetic information on it. We are planning to place different pathways on it including for example the beta-carotene pathway. As our final goal is to have cells that primarily produce our compound we are planning to erase all other information from the cell by digesting the main host chromosome at a given time point.<br>  
<a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation </a> page.</p>
+
The other path that we are following is using a system where the cells divide unequally and therefore produce so called mini cells. In these cells there is no host chromosome but by chance our synthetic chromosome with its encoded information. These mini cells will then be producing only our wanted compounds.<br>  
 
+
With both approaches the cells will be technical not longer alive because they are not able to divide anymore. Therefore we can minimize the risk of setting genetically modified organisms free. This allows us to use them for many different purposes. On the one hand we build with this a technology that allows us to produce a variety of different chemical compounds in a semi cell-free systems. Our projects will solve the bottlenecks of cell free productions systems e.g. the production and purification of enzymes. On the other hand we can also look in more advanced applications including for example using them as a targeted drug delivery system. We are planning to do experiments where the pathway is just expressed when a signaling molecule e.g. form a pathogenic bacteria is secreted.<br>  
 
+
We hope we could highlight the context where we placed our project in and what are the benefits.  
<h4>Tips</h4>
+
</p>
<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
+
<ul>
+
<li>State your accomplishments! Tell people what you have achieved from the start. </li>
+
<li>Be clear about what you are doing and how you plan to do this.</li>
+
<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
+
<li>Make sure information is easy to find; nothing should be more than 3 clicks away. </li>
+
<li>Avoid using very small fonts and low contrast colors; information should be easy to read. </li>
+
<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2015.igem.org/Calendar_of_Events">iGEM 2015 calendar</a> </li>
+
<li>Have lots of fun! </li>
+
</ul>
+
 
+
 
+
<h4>Inspiration</h4>
+
<p> You can also view other team wikis for inspiration! Here are some examples:</p>
+
<ul>
+
<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
+
<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
+
<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
+
<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
+
<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
+
<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
+
</ul>
+
 
+
<h4> Uploading pictures and files </h4>
+
<p> You can upload your pictures and files to the iGEM 2015 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
+
When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
+
 
+
<a href="https://2015.igem.org/Special:Upload">CLICK HERE TO UPLOAD FILES</a>
+
 
+
 
+
 
+
</div></div> <!--These are the closing tags for div id="mainContainer" and div id="contentContainer". The corresponding opening tags appear in the template that is {{included}} at the top of this page.-->
+
  
 +
</body>
 
</html>
 
</html>

Revision as of 21:44, 14 July 2015

This page is in progress!

Our Projects:

Curli fibres

Our main goal is to produce new nutrition out of agrar-culture waste. Therefore we combined the best features of chemistry and biology for the degradation of cellulose to glucose. In this regard, we took the chemical degration of cellulose via phosphoric acid and combined it with the biological way of storing it in a stable hydroxylapatite matrix. This matrix is build up of modified curli fibres, on which the hydroxylapatite crystalized out and can be reactivated by lacto bacillus. This system is an enclosed cellulose capsule, which maintains a high and stable phosphoric acid concentration. Through the high and local concentration of phosphoric acid the surrounding cellulose gets efficiently degraded. Main advantages are that the phosphoric acid can be handled safely.


Synthetic Chromosome and Minicells

The Synthetic Chromosome is derived form the secondary Chromosome of Vibrio Cholerae. The structure and stability of this genetic element opens up the possibility of adding a lot of genetic information on it. We are planning to place different pathways on it including for example the beta-carotene pathway. As our final goal is to have cells that primarily produce our compound we are planning to erase all other information from the cell by digesting the main host chromosome at a given time point.
The other path that we are following is using a system where the cells divide unequally and therefore produce so called mini cells. In these cells there is no host chromosome but by chance our synthetic chromosome with its encoded information. These mini cells will then be producing only our wanted compounds.
With both approaches the cells will be technical not longer alive because they are not able to divide anymore. Therefore we can minimize the risk of setting genetically modified organisms free. This allows us to use them for many different purposes. On the one hand we build with this a technology that allows us to produce a variety of different chemical compounds in a semi cell-free systems. Our projects will solve the bottlenecks of cell free productions systems e.g. the production and purification of enzymes. On the other hand we can also look in more advanced applications including for example using them as a targeted drug delivery system. We are planning to do experiments where the pathway is just expressed when a signaling molecule e.g. form a pathogenic bacteria is secreted.
We hope we could highlight the context where we placed our project in and what are the benefits.