Difference between revisions of "Team:Evry"
Knakiballz (Talk | contribs) (Abstract modified as the project description is due today. :)) |
Knakiballz (Talk | contribs) (Corrected a bit our first abstract draft, by adding a few things. :)) |
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<h2>Abstract</h2> | <h2>Abstract</h2> | ||
<p class="lead">Our immune system is a dynamic balance between <strong>immunity</strong> and <strong>tolerance</strong>.</p> | <p class="lead">Our immune system is a dynamic balance between <strong>immunity</strong> and <strong>tolerance</strong>.</p> | ||
| − | <p class="text-justify" style="font-size: 120%;">This complex mechanism can be impaired, leading to deleterious effects. In <strong>cancer</strong>, the immune system is <strong> | + | <p class="text-justify" style="font-size: 120%;">This complex mechanism can be impaired, leading to deleterious effects. In <strong>cancer</strong>, the immune system is <strong>tolerant to tumor-associated antigens</strong> that bear homology to self, and is therefore prevented from targeting tumor cells. On the contrary, in <strong>food allergies or inflammatory diseases</strong>, the immune system <strong>overreacts</strong>.</p> |
| − | <p class="text-justify" style="font-size: 120%;">Major players of the immune response are <strong>dendritic cells</strong> | + | <p class="text-justify" style="font-size: 120%;">Major players of the immune response are <strong>dendritic cells</strong>, that present the antigen to the T cells to ;ature them, leading to an adapted immune response. So we decided to modulate their activity using engineered <em>S. cerevisiae</em> to <strong>rebalance the system</strong>. Our strategy is to <a href="https://2015.igem.org/Team:Evry/Project/Induction">induce</a> or <a href="https://2015.igem.org/Team:Evry/Project/Repression">repress</a> the immune response through constructions based on known immune modulating molecules which will be expressed at yeast surface and released in the targeted tissues.</p> |
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| + | <p class="text-justify" style="font-size: 120%">Thus, in our <strong>induction</strong> project, we are aiming to present <strong>tumor-associated antigens</strong> to dendritic cells, to <strong>break the immune tolerance</strong>, while bringing a favorable immune environment into the tumor with molecules such as cytokines. </p> | ||
<hr> | <hr> | ||
<!--p class="lead text-justify">Our immune system can be seen as a balance between immunity and tolerance. | <!--p class="lead text-justify">Our immune system can be seen as a balance between immunity and tolerance. | ||
Revision as of 22:33, 15 July 2015
Welcome!
Abstract
Our immune system is a dynamic balance between immunity and tolerance.
This complex mechanism can be impaired, leading to deleterious effects. In cancer, the immune system is tolerant to tumor-associated antigens that bear homology to self, and is therefore prevented from targeting tumor cells. On the contrary, in food allergies or inflammatory diseases, the immune system overreacts.
Major players of the immune response are dendritic cells, that present the antigen to the T cells to ;ature them, leading to an adapted immune response. So we decided to modulate their activity using engineered S. cerevisiae to rebalance the system. Our strategy is to induce or repress the immune response through constructions based on known immune modulating molecules which will be expressed at yeast surface and released in the targeted tissues.
Thus, in our induction project, we are aiming to present tumor-associated antigens to dendritic cells, to break the immune tolerance, while bringing a favorable immune environment into the tumor with molecules such as cytokines.
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