Difference between revisions of "Team:Technion Israel"

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<link rel="stylesheet" href="css/style.css"/>
 
 
<title>Team: Technion 2015</title>
 
<title>Team: Technion 2015</title>
 
</head>
 
</head>
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<header>
 
<header>
<!--<a href="#" ID=igem_login>Log in</a>-->
 
 
 
 
<img src="https://static.igem.org/mediawiki/2015/f/fc/Team_Technion_Logo.png" alt="Team Logo" id="team_logo" />
 
<img src="https://static.igem.org/mediawiki/2015/f/fc/Team_Technion_Logo.png" alt="Team Logo" id="team_logo" />
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<span class="btn-bg2"></span>
 
<div class="sub2">
 
<div class="sub2">
<a href="#">sublink1</a>
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<a href="#">Overview</a>
<a href="#">sublink2</a>
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<a href="#">Protocols</a>
<a href="#">sublink3</a>
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<a href="#">Plasmids</a>
 
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</div>
 
</div>
 
</div>
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<div class="content">
 
<div class="content">
<h1 class="abstract_title">Hello! Welcome to our temporary wiki page!</h1>
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<h1 class="abstract_title">page title</h1>
 
<div class="abstract">
 
<div class="abstract">
 
<b>Our team is developing a treatment for male pattern baldness.</b>
 
<b>Our team is developing a treatment for male pattern baldness.</b>
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Revision as of 06:46, 9 August 2015

Team: Technion 2015

page title

Our team is developing a treatment for male pattern baldness.

Hair loss affects roughly 61 million people in the United States. More than 95% of hair thinning in men is attributed to male pattern baldness, or androgenetic alopecia. The hair loss product market is a multi-billion dollar market: in the United States alone, this market’s annual revenue is 7 billion dollars, with 3.5% annual growth rate from 2007 to 2012, yet a sufficient solution has yet to be made available. The trigger for androgenetic alopecia is believed to be dihydrotestosterone (DHT), a derivative of testosterone. This summer, we are engineering Bacillus Subtilis, a model organism for a bacterium found naturally on the scalp, to secrete 3α-hydroxysteroid dehydrogenase (3-α-HSD). This enzyme reduces DHT to a non-steroidically active compound, using NADPH and NADH as cofactors.

Our project consists of 3 main parts: 3-α-HSD secretion by the bacterium, engineered bacterium for NADPH overproduction, and a comb as a tool to create a user-friendly experience. By synchronizing these parts, we hope to be able to show convincing evidence of DHT breakdown, providing a promising platform for treatment of male pattern baldness!

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