Difference between revisions of "Team:Technion Israel"

Line 52: Line 52:
 
<!---------------------------------------dropdown menu----------------------------------->
 
<!---------------------------------------dropdown menu----------------------------------->
 
<div class="dropdown">
 
<div class="dropdown">
<a href="#">
+
<a href="https://2015.igem.org/Team:Technion_Israel">
 
<img src="https://static.igem.org/mediawiki/2015/c/c1/Team_Technion_Navbar_Home.png" alt="Home" id="home_nav" />
 
<img src="https://static.igem.org/mediawiki/2015/c/c1/Team_Technion_Navbar_Home.png" alt="Home" id="home_nav" />
 
<div id="home_text">Navigate</div>
 
<div id="home_text">Navigate</div>
Line 70: Line 70:
 
<span class="btn-bg2"></span>
 
<span class="btn-bg2"></span>
 
<div class="sub2">
 
<div class="sub2">
<a href="#">Overview</a>
+
<a href="https://2015.igem.org/Team:Technion_Israel/Lab_Notebook/Overview">Overview</a>
 
<a href="#">Protocols</a>
 
<a href="#">Protocols</a>
 
<a href="#">Plasmids</a>
 
<a href="#">Plasmids</a>

Revision as of 11:18, 9 August 2015

Team: Technion 2015

page title

Our team is developing a treatment for male pattern baldness.

Hair loss affects roughly 61 million people in the United States. More than 95% of hair thinning in men is attributed to male pattern baldness, or androgenetic alopecia. The hair loss product market is a multi-billion dollar market: in the United States alone, this market’s annual revenue is 7 billion dollars, with 3.5% annual growth rate from 2007 to 2012, yet a sufficient solution has yet to be made available. The trigger for androgenetic alopecia is believed to be dihydrotestosterone (DHT), a derivative of testosterone. This summer, we are engineering Bacillus Subtilis, a model organism for a bacterium found naturally on the scalp, to secrete 3α-hydroxysteroid dehydrogenase (3-α-HSD). This enzyme reduces DHT to a non-steroidically active compound, using NADPH and NADH as cofactors.

Our project consists of 3 main parts: 3-α-HSD secretion by the bacterium, engineered bacterium for NADPH overproduction, and a comb as a tool to create a user-friendly experience. By synchronizing these parts, we hope to be able to show convincing evidence of DHT breakdown, providing a promising platform for treatment of male pattern baldness!

Contact Us