Team:HSNU-TAIPEI/Project/Benzo a pyrene

 Benzo[a]pyrene

 ✡ Introduction

   (1)Why do we detect benzo[a]pyrene?

   Because when food,such as fried food ,which is heated above 300 degrees

   celcius,food will release benzo[a]pyrene recycled oil usually contain

   benzo[a]pyrene[1].

   (2)Harm?

   Pathway:from skin,breathing in,eating Carcinogenic,environmental

   pollution, Skin irritation,eye irritation[1].

   (3)Taiwanese regulation

[2]

   (4)National regulation

   Europe:The same to Taiwanese regulation[2]

   American:The MCL has been set at 0.2 ppb[3]

 ✡ Circuit Design

   MerR可以和汞結合然後改變DNA的結構好讓RNA聚合酶方便轉入。

   PmerT可以被MerR控制。PmerT步行進行轉錄是因為MerR會改變PmerT的

   形狀。總而言之，只要汞與MerR結合，後續反應就可進行。(註3)(註4)

 ✡ Result

 ✡ Reference

   (註1)Metabolism of mercury, administered as methylmercuric chloride or mercuric chloride, by lactating ruminants.

   (註2)台北醫學大學公共衛生學系碩士班碩士論文Graduate Institute.

   (註3)Brown, N. L., J. V. Stoyanov, et al. (2003). "The MerR family of transcriptional regulators." FEMS Microbiol Rev 27(2-3): 145-163.

   (註4)Park, S. J., J. Wireman, et al. (1992). "Genetic analysis of the Tn21 mer operator-promoter." J Bacteriol 174(7): 2160-2171.