Team:Oxford
Welcome to the home page of Oxford University's 2015 iGEM Team!
Original artwork by the 2015 Oxford iGEM Team
Project Summary
We are interested in developing an autonomous antibacterial system using an E. coli chassis through synthetic biology. Our antibacterial strategy involves a two-step mechanism: i) Destroy the bacterial biofilm which confers the bacteria encased within significantly increased resilience against antibiotics ii) Destroy the liberated bacteria by directly lysing their cell walls. We will be experimenting with antibacterial action against E. coli and P. aeruginosa.
Antibiofilm action
The cartoon above shows two of the major structural components of bacterial biofilms - extracellular polymeric substance (in blue)