Team:Aalto-Helsinki/Modeling cellulose

• Project
• Modeling
  • Models of propane pathway
    • Kinetics of propane pathway
    • Model of CAR activation
  • Synergy model
  • Micelle model
  • About cellulose pathway
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  • Lab Book
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  • Practice project
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  • Continuous production
  • Submitted parts
  • Achievements
  • Future
• Practices
  • Combining modeling and experimentation in iGEM
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    • InterLabBook
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Under construction

We wanted to be able to produce the propane with cellulose, and for that we needed models of our cellulose pathway. We modeled the pathway the same way that we did with propane pathway.

Derministic modeling of the reaction pathway

Finding bottlenecks in our reactions, identifying which substrates could be overproduced, and comprehending better the role each component, as the substrates concentrations, plays in our pathway are a few of the reasons we decided to do a deterministic model. With the help of differential equations applied to each reaction, we could have simultaneously a specific and a broad view of our pathway.

Sensitivity analysis

We wanted to go further in our understanding of the cellulose reaction pathway. By completing our deterministic model, it became easier for us to interpret how each substrate affects another one in our system. This is crucial for us to then invest more resources in those substrates that affect the most our propane production, the main goal of this project.

Stability analysis

We wanted to know whether our pathway could produce glucose from cellulose steadily. In order to understand if this would be plausible, we performed a stability analysis of our reaction. To conclude these calculations, we used again the ideas behind our deterministic modeling.