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Supervisors
Prof dr. M. (Maarten) Merkx
Maarten Merkx (1970) studied physical organic chemistry and biochemistry at the Radboud University Nijmegen (cum laude).
He did his PhD with Prof. Averill (University of Amsterdam) working on purple acid phosphatases, and subsequently was a Human Frontier of Science Program post-doctoral fellow with Prof. Lippard (MIT) studying methane monooxgenases. Currently he is associate professor in protein engineering at the Eindhoven University of Technology. An important
research theme is to develop generic engineering concepts for the development of protein-based switches, which include
fluorescent sensors for intracellular imaging of metal ions, photo-switchable proteins, and protein-based sensors for antibody detection. He obtained young investigator grants from the HFSP and NWO (VIDI, 2006) and an ERC consolidator grant in 2011.In 2012 he received the award for the best TU/e teacher at the master level.
Dr. Ir. T.F.A. (Tom) de Greef
Dr. Ir. Tom de Greef was born in Eindhoven, the Netherlands, in 1980. He studied at the University of Eindhoven (TU/e, the Netherlands), where he received his M.Sc. degree in Biomedical Engineering cum laude in 2004. He completed his Ph.D. at the Department of Chemistry at the same university in 2008 with professors E. W. Meijer and R. P. Sijbesma. The subject of his Ph.D. work concerned the synthesis of novel materials based on quadruple hydrogen bonding motifs. Subsequently, he moved to the Biomodeling and Bioinformatics group of prof. P. A. J. Hilbers at the Department of Biomedical Engineering (TU/e) and focused on the kinetic modeling of a large variety of self-assembling systems using deterministic as well as stochastic modeling approaches. In 2010, Tom de Greef started as assistant professor (tenure track) in Physical Chemistry at the Department of Biomedical Engineering and the Institute for Complex Molecular Systems at the TU/e. His work has been directed towards understanding the physical basis for the self-assembly of artificial and biological molecules using a combined experimental and theoretical approach.
Prof.dr.ir. L. (Luc) Brunsveld
Luc (Lucas) Brunsveld (1975) received his PhD degree in 2001 under supervision of prof. Bert Meijer at the Eindhoven University of Technology. Topic of the thesis was the self-assembly of designed molecules into helical architectures in water. Subsequently, he moved as a Humboldt fellow to the Max Planck Institute of Molecular Physiologie, Dortmund, to work on the protein semi-synthesis and evaluation of lipidated Ras GTPases in the group of prof. Herbert Waldmann. From 2003-2004 he worked as a group leader in the medicinal chemistry department of Organon (now Schering-Plough) in Oss, on nuclear receptor medicinal chemistry.
End of 2004 Luc Brunsveld received the Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation, with which he established his own research group at the MPI of Molecular Physiologie, Dortmund, beginning 2005, working on the combination of supramolecular chemistry with protein biochemistry and cellular biology, generating new approaches to modulate biological processes. In 2006 he in addition became group leader at the Chemical Genomics Centre of the Max Planck Society, Dortmund, working on the chemical biology of nuclear receptors to understand and modulate the nuclear receptor-cofactor interaction, in close collaboration with Bayer-Schering Pharma, Merck-Serono, and Schering-Plough.
In the middle of 2008 Luc Brunsveld received an ERC starting grant and became full professor in chemical biology in the Department of Biomedical Engineering at the Eindhoven University of Technology.In his research Luc Brunsveld uses chemical biology approaches to study protein-protein interactions. Two general themes are followed: 1) Supramolecular Architectures are being pursued as instruments to modulate protein-protein interactions and 2) the Nuclear Receptor – Cofactor interaction is being investigated as a specific protein-protein interaction with many unsolved questions, possibly amendable via chemical biology
End of 2004 Luc Brunsveld received the Sofja Kovalevskaja Award from the Alexander von Humboldt Foundation, with which he established his own research group at the MPI of Molecular Physiologie, Dortmund, beginning 2005, working on the combination of supramolecular chemistry with protein biochemistry and cellular biology, generating new approaches to modulate biological processes. In 2006 he in addition became group leader at the Chemical Genomics Centre of the Max Planck Society, Dortmund, working on the chemical biology of nuclear receptors to understand and modulate the nuclear receptor-cofactor interaction, in close collaboration with Bayer-Schering Pharma, Merck-Serono, and Schering-Plough.
In the middle of 2008 Luc Brunsveld received an ERC starting grant and became full professor in chemical biology in the Department of Biomedical Engineering at the Eindhoven University of Technology.In his research Luc Brunsveld uses chemical biology approaches to study protein-protein interactions. Two general themes are followed: 1) Supramolecular Architectures are being pursued as instruments to modulate protein-protein interactions and 2) the Nuclear Receptor – Cofactor interaction is being investigated as a specific protein-protein interaction with many unsolved questions, possibly amendable via chemical biology