Team:IIT Delhi/modelling

• BACKGROUND
• SOLUTION
• RESEARCH
• PROTOTYPE
• CONCLUSION

• SUMMARY
• TIMELINE
• ALBUM

• PARTS SUBMITTED
• JUDGING CRITERION
• ATTRIBUTES

• INTRODUCION
• MATHEMATICAL MODEL
• SIMULATION
• INTERPRETATION

• OUR STORY
• MENTORS
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• CARPE DIEM

• IISER
• ENACTUS
• OUTREACH

• ORIENTATION
• OPEN HOUSE
• TRYST
• SURVEYS

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  • NOTEBOOK
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  • TIMELINE
  • ALBUM

  • RESULTS
  • PARTS SUBMITTED
  • JUDGING CRITERION
  • ATTRIBUTIONS

  • MODELLING
  • INTRODUCTION
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  • SIMULATION
  • INTERPRETATION

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MODELING

• Introduction
• Mathematical Model
• Simulation
• Interpretaion

Mathematical Model Three of the proteins required in the project are cytochrome c proteins (haem proteins). Hence, the heme biosynthesis pathway needs to be modelled. Pathway of heme production in E. coli (C-5 pathway from glutamate)

Surveys (August 2015) Also,d-Aminolevulinate (ALA) produced as an intermediate in the above reactions. -Aminolevulinate Synthase (ALA Synthase) is the committed step of the heme synthesis pathway, and is usually rate-limiting for the overall pathway. Regulation occurs through control of gene transcription. Heme functions as a feedback inhibitor, repressing transcription of the gene for -Aminolevulinate Synthase.

Mathematical Model A non-competitive irreversible feedback inhibition model is assumed for this step with a ki value of 0.02 mM. Hence, the following equation governs the conversion to ALA: