Template:Heidelberg/project/standardization/HRP
HRP-mimicking DNAzyme
HRP-mimicking DNAzyme folds into a G-quadruplex and binds hemin into it. Upon binding of the hemin to the G-quadruplex the DNAzyme catalyzes the reduction of H2O2 to H2O and a reactive oxygen species and thus result to the activation of a classical HRP substrate like luminol.
![](https://static.igem.org/mediawiki/2015/d/d0/Heidelberg_CLT_Fig.3_HRPDNAzyme.png)
HRP-micking DNAzyme
HRP-mimicking DNAzyme folds into a G-quadruplex and binds hemin into it. Upon binding of the hemin to the G-quadruplex the DNAzyme catalyzes the reduction of H2O2 to H2O and a reactive oxygen species and thus result to the activation of a classical HRP substrate like luminol.