Team:UI Indonesia/Modeling

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Modelling of Bacterial Contraception

(A) Toggle switch is a gene synthetic network that was discovered and constructed in Escherichia coli by Tim Gerdner, Charles Cantor, and Jim Collins. Naturally, toggle switch gene synthetic network found in lambda bacteriophage for regulate its lytic and lysogenic cycle. In synthetic biology, toggle switch use for regulating bistability of two expression system by orientating to one expression system depends on strength of the promoter and inducer or repressor concentration

B. SboAConcentrationNeeded for ImmobilizingSperm


C. Toggle Switch Logic



D. Toggle switch mass action kinetic equation



E. Toggle switch mass action kinetic equation



F. Toggle switch mass action kinetic equation



G. Toggle switch mass action kinetic equation

Thats all the thoritical modelling that made by our team. We can’t do the “Real” modelling because our wet lab project haven’t done yet when I made this.

References :
• Structure of subtilosin A, a cyclic antimicrobial peptide from Bacillus subtilis with unusual sulfur to alpha-carbon cross-links: formation and reduction of alpha-thio-alpha-amino acid derivatives
• Kawulka KE, Sprules T, Diaper CM, Whittal RM, McKay RT, Mercier P, Zuber P, Vederas JC