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Logic
From a truth table to abstract logic circuits
In BioBLESS, a truth table dialog box will be displayed for users to input Boolean numbers 0/1. All you need to do is to click Boolean buttons and then “Create”. The corresponding designed logic circuits with different predicted performances will be automatically generated and displayed in order. You can immediately and clearly see the configuration of a designed logic circuit, which in most cases is supposed to be a complicated multi-input circuit. Besides the function above, gates list will provide many Boolean gates, and users can drag them freely to our canvas to design logic circuits.
GENE CIRCUIT
See the detailed structure of a designed gene circuit
A single click on “?” button will bring you to another tab
where the detailed structure of your designed gene circuit
is shown. If you want to see the abstract structure, just
click “?” button and you will see configuration of every
Boolean gate hidden behind gate symbols.
SIMULATION
Get concentration-time simulation results
Given a designed gene circuit, such as a simple serial circuit
composed of an AND gate and a OR gate, you only need to input
parameters to confirm the initial concentration of reactants
and the rate of reactions, namely, to fill constant into the
dialog boxes corresponding to designed gene circuits on our
canvas. Simulation time slot is needed as well to give
concentration-time figures of the inputs and outputs of a
given gene circuit.
ANALYSIS
Get robustness and sensitivity analysis
While offering various functions, BioBLESS also serves as
analysis tool for designed gene circuit. When you have
designed a gene circuit, you can click the “analysis”
button to reset robustness analysis parameters. Meanwhile,
BioBLESS will set simulation slots and carry the simulation
task automatically. According to the
perturbation-to-background ratio you input, such as 20%
or 30%, the concentration-time curves of inputs and
outputs will be shown together to give
a visualized intuition on the robustness
of a designed gene circuit.
DNA
Get the DNA sequence!
Users have the freedom to drag specific BioBricks on our canvas and
combine them into a functional gene circuit. Then the DNA sequence
and other information of the designed circuit are available for users
to check and download. Wet lab protocols are partly incorporated into
our DNA sequences which may make the design better and applicable in
laboratories.
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USTC-Software 2015
University of Science and Technology of China
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