Team:Vanderbilt/Project/Achievements

Demons in the Code

Background Sequence Circuit Organism Nanopore Achievements

Sequence

• Invented an innovative software tool for minimizing any gene’s susceptibility to mutation Validated rapid spread of mutants in a genetically modified population by mathematical and empirical techniques
Experimentally validated decreased mutation in optimized sequences with
• Multiple mutagen types (UV radiation, oxidation)
• Multiple quantification protocols (Alkaline gel, plasmid conformation, PCR inhibition)
• Established high expression of optimized sequences
• Modeling and computational strategies for further improvements and expansion of software
• Investigated potential for nanopore sequencing to become next-generation of ultra high-throughput DNA damage detection

Organism



Circuit



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Project

Background
Sequence
Circuit
Organism
Nanopore
Achievements


Parts

Part Collection
Optimized RFPs
Visualizing Evolution
Repair Enzymes


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