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Welcome to SCUT-China

project description

Cardiovascular diseases are the leading cause of death in many developed countries.Myocardial ischemia is one of main consequences of cardiovascular disease and can be characterized into several forms,such as myocardial hypertrophy.There are several Cardiovascular drugs，but always with side effect and enormous expense.This summer we try to use synthetic biology methods to help the therapy of myocardial hypertrophy .We hope our work will pave the way for future gene therapy.

We found that stimulating Cyclic guanosine monophosphate (cGMP),a second messenger molecule that transduces nitric-oxide and natriuretic-peptide-coupled signalling,could remit the myocardial hypertrophy by relaxing the vessels.So we aimed to up regulate the concentration of soluble guanylate cyclase(sGC), an enzyme that catalyze GTP to cGMP,with two methods. Firstly, we construct lentivirusvectors that can express the αand β units of sGC that combine together to form sGC . Secondly, the lentivirus vectors carrying shRNAwill silence the gene coding for PDE5A,a cGMP-specific phosphodiesteras that degrades cGMP. However, up-regulating cGMP all the time may give rise to unknown side effects.To make our system safer, we designed a hypoxia-inducible operon,HRE,as a switch and up regulate cGMP only inhypoxia situation.

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