Difference between revisions of "Team:Stockholm/ethics"

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<img src="https://static.igem.org/mediawiki/2015/c/ca/Practices.jpg" class="img-responsive" alt="ABBBA Infographic"/>
 
<img src="https://static.igem.org/mediawiki/2015/c/ca/Practices.jpg" class="img-responsive" alt="ABBBA Infographic"/>
  
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<h2>Bringing human practices to synthetic biology <br> Ethics, entrepreneurship and education</h2>
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<h1>Bringing human practices to synthetic biology <br> Ethics, entrepreneurship and education</h1>
  
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<p>Early diagnosis is important for patient prognosis. As a rule of thumb, the earlier a disease is diagnosed, the better the odds for recovery. Studies show that treatment for many different diseases (e.g. cancer) are more efficient when therapy is started at an early stage. Yet, reliable, sensitive and easily applicable diagnostic tools are still lacking.</p>
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<p>Lorem ipsum dolor sit amet, consectetur adipiscing elit. Fusce eget diam luctus, lobortis orci quis, iaculis elit. Cras cursus ex porta purus maximus, condimentum dictum tellus suscipit. Ut gravida nibh sem, ac efficitur enim volutpat vel. Sed blandit est eu lorem luctus ultricies a vel diam. Integer euismod diam nec diam auctor euismod. Phasellus molestie porttitor erat at ultricies. Etiam convallis luctus justo non consequat. Cras nec ligula ultricies, interdum dui eu, tempor diam. Etiam a arcu quis mi convallis blandit. Suspendisse facilisis vulputate est sed pharetra. Nunc sodales libero arcu, sed pulvinar mi sollicitudin at. Nam rutrum et metus id elementum. Pellentesque et ligula vitae metus lobortis efficitur et vel nunc. Curabitur consequat lectus ligula, id dignissim nisi tempor eu.</p>
  
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<p>iGEM Stockholm 2015, consisting of students from Karolinska Institutet and the Royal Institute of Technology KTH, is developing a novel technique to measure even small amounts of disease biomarker in body fluids. It's an "Affibody-Based Bacterial Biomarker Assay", and we call it ABBBA. As proof-of-principle, we wanted to sensitize E.Coli against the cancer biomarker HER-2 by creating a chimeric receptor. We used the Affibody molecule – a strong molecular binder – and the osmoregulator EnvZ originating from E.Coli. Exploiting the EnvZ-OmpR signaling cascade, we wanted to transduce a signal from binding into the cell. In our circuit, this event regulates differential expression of two quorum sensing molecules depending on the presence of the biomarker. A co-cultured strain will then detect these quorum sensing molecules express fluorescence.</p>
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<h2>Ethics: How are negative results treated in iGEM? </h2>
  
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<p>In the time frame of the project, we synthesized three biobricks of a chimeric antigen receptor. We have not yet show the expression of the receptor in E.Coli TOP10 cells. We designed and characterized an OmpR-P dependent circuit to express GFP, which we later exchanged with a quorum sensing synthetase. Furthermore, we showed that our strain expresses RFP as a response to quorum sensing.</p>
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<p>Nunc vitae neque lorem. Interdum et malesuada fames ac ante ipsum primis in faucibus. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Duis vel ipsum quis sapien gravida maximus sit amet id ante. Vestibulum fringilla placerat neque eget laoreet. Nunc eget felis congue, tincidunt est in, egestas ipsum. Cras enim elit, elementum eget mattis id, tincidunt nec purus. Donec dignissim orci eget ante sagittis dapibus. Nam in laoreet sapien. Cras vitae ullamcorper dui, nec sollicitudin orci. Donec sagittis pharetra ex, eget ultrices nisl rhoncus eget.</p>
  
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<p>We have also cooperated on science and social issues with teams from Switzerland, Israel, Germany, France, Helsinki, Taiwan and Uppsala.</p>
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<h2>Entrepreneurship: How to bring ABBBA to the market</h2>
  
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<p>Nunc vitae neque lorem. Interdum et malesuada fames ac ante ipsum primis in faucibus. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Duis vel ipsum quis sapien gravida maximus sit amet id ante. Vestibulum fringilla placerat neque eget laoreet. Nunc eget felis congue, tincidunt est in, egestas ipsum. Cras enim elit, elementum eget mattis id, tincidunt nec purus. Donec dignissim orci eget ante sagittis dapibus. Nam in laoreet sapien. Cras vitae ullamcorper dui, nec sollicitudin orci. Donec sagittis pharetra ex, eget ultrices nisl rhoncus eget.</p>
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<h2>Education: Spreading the word</h2>
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<p>Nunc vitae neque lorem. Interdum et malesuada fames ac ante ipsum primis in faucibus. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Duis vel ipsum quis sapien gravida maximus sit amet id ante. Vestibulum fringilla placerat neque eget laoreet. Nunc eget felis congue, tincidunt est in, egestas ipsum. Cras enim elit, elementum eget mattis id, tincidunt nec purus. Donec dignissim orci eget ante sagittis dapibus. Nam in laoreet sapien. Cras vitae ullamcorper dui, nec sollicitudin orci. Donec sagittis pharetra ex, eget ultrices nisl rhoncus eget.</p>
 
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Revision as of 12:36, 4 September 2015

ABBBA Infographic

Bringing human practices to synthetic biology
Ethics, entrepreneurship and education

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Fusce eget diam luctus, lobortis orci quis, iaculis elit. Cras cursus ex porta purus maximus, condimentum dictum tellus suscipit. Ut gravida nibh sem, ac efficitur enim volutpat vel. Sed blandit est eu lorem luctus ultricies a vel diam. Integer euismod diam nec diam auctor euismod. Phasellus molestie porttitor erat at ultricies. Etiam convallis luctus justo non consequat. Cras nec ligula ultricies, interdum dui eu, tempor diam. Etiam a arcu quis mi convallis blandit. Suspendisse facilisis vulputate est sed pharetra. Nunc sodales libero arcu, sed pulvinar mi sollicitudin at. Nam rutrum et metus id elementum. Pellentesque et ligula vitae metus lobortis efficitur et vel nunc. Curabitur consequat lectus ligula, id dignissim nisi tempor eu.

Ethics: How are negative results treated in iGEM?

Nunc vitae neque lorem. Interdum et malesuada fames ac ante ipsum primis in faucibus. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Duis vel ipsum quis sapien gravida maximus sit amet id ante. Vestibulum fringilla placerat neque eget laoreet. Nunc eget felis congue, tincidunt est in, egestas ipsum. Cras enim elit, elementum eget mattis id, tincidunt nec purus. Donec dignissim orci eget ante sagittis dapibus. Nam in laoreet sapien. Cras vitae ullamcorper dui, nec sollicitudin orci. Donec sagittis pharetra ex, eget ultrices nisl rhoncus eget.

Entrepreneurship: How to bring ABBBA to the market

Nunc vitae neque lorem. Interdum et malesuada fames ac ante ipsum primis in faucibus. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Duis vel ipsum quis sapien gravida maximus sit amet id ante. Vestibulum fringilla placerat neque eget laoreet. Nunc eget felis congue, tincidunt est in, egestas ipsum. Cras enim elit, elementum eget mattis id, tincidunt nec purus. Donec dignissim orci eget ante sagittis dapibus. Nam in laoreet sapien. Cras vitae ullamcorper dui, nec sollicitudin orci. Donec sagittis pharetra ex, eget ultrices nisl rhoncus eget.

Education: Spreading the word

Nunc vitae neque lorem. Interdum et malesuada fames ac ante ipsum primis in faucibus. Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Duis vel ipsum quis sapien gravida maximus sit amet id ante. Vestibulum fringilla placerat neque eget laoreet. Nunc eget felis congue, tincidunt est in, egestas ipsum. Cras enim elit, elementum eget mattis id, tincidunt nec purus. Donec dignissim orci eget ante sagittis dapibus. Nam in laoreet sapien. Cras vitae ullamcorper dui, nec sollicitudin orci. Donec sagittis pharetra ex, eget ultrices nisl rhoncus eget.

iGEM Stockholm is made possible with support from: