Difference between revisions of "Team:Marburg"

 
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<h1 style="color:green"><center>This page is in progress!</center></h1>
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<h2 style="font-size:150%">Our Projects:</h2>
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<h2>Curli fibres</h2>
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<p>Our main goal is to produce new nutrition out of agrar-culture waste. Therefore we combined the best features of chemistry and biology for the degradation of cellulose to glucose. In this regard, we took the chemical degration of cellulose via phosphoric acid and combined it with the biological way of storing it in a stable hydroxylapatite matrix. This matrix is build up of modified curli fibres, on which the hydroxylapatite crystalized out and can be reactivated by lacto bacillus. This system is an enclosed cellulose capsule, which maintains a high and stable phosphoric acid concentration. Through the high and local concentration of phosphoric acid the surrounding cellulose gets efficiently degraded. Main advantages are that the phosphoric acid can be handled safely.</p><br>
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<h2>Synthetic Chromosome and Minicells</h2>
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<p>The Synthetic Chromosome is derived form the secondary Chromosome of Vibrio Cholerae. The structure and stability of this genetic element opens up the possibility of adding a lot of genetic information on it. We are planning to place different pathways on it including for example the beta-carotene pathway. As our final goal is to have cells that primarily produce our compound we are planning to erase all other information from the cell by digesting the main host chromosome at a given time point.<br>  
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The other path that we are following is using a system where the cells divide unequally and therefore produce so called mini cells. In these cells there is no host chromosome but by chance our synthetic chromosome with its encoded information. These mini cells will then be producing only our wanted compounds.<br>  
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With both approaches the cells will be technical not longer alive because they are not able to divide anymore. Therefore we can minimize the risk of setting genetically modified organisms free. This allows us to use them for many different purposes. On the one hand we build with this a technology that allows us to produce a variety of different chemical compounds in a semi cell-free systems. Our projects will solve the bottlenecks of cell free productions systems e.g. the production and purification of enzymes. On the other hand we can also look in more advanced applications including for example using them as a targeted drug delivery system. We are planning to do experiments where the pathway is just expressed when a signaling molecule e.g. form a pathogenic bacteria is secreted.<br>  
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We hope we could highlight the context where we placed our project in and what are the benefits. </p>
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<li><a href="https://2015.igem.org/Team:Marburg/Projects" class="first"><img src="https://static.igem.org/mediawiki/2015/5/56/MR_pic_Projects.png" style="height:60px;text-align:center;"></a>
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<ul>
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<li><a href="https://2015.igem.org/Team:Marburg/Description">Overview</a></li>
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                                                                <li><a href="https://2015.igem.org/Team:Marburg/Background">Fact Sheets</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Minicells">NUTRInity - Provide</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Curli">NUTRInity - Pick up</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/CDI">NUTRInity - Cut off</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Design">Future Application</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/InterLab">InterLab Study</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Measurement">Measurement Study</a></li>
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<ul>
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<li><a href="https://2015.igem.org/Team:Marburg/iGeneration">iGeneration</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Hessentag">Hessentag</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Killswitch">KillSwitch Statistics</a></li>
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</ul>
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<li><a href="https://2015.igem.org/Team:Marburg/Achievements" class="first"><img src="https://static.igem.org/mediawiki/2015/b/ba/MR_pic_Achievements.png" style="height:60px;"></a>
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<ul>
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<li><a href="https://2015.igem.org/Team:Marburg/Parts">Parts</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Results">Results</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Medal Fulfillment">Medal Fulfillment</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Meetup">MeetUp</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Gameofcells">Game of Cells</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Notebook" class="first"><img src="https://static.igem.org/mediawiki/2015/5/53/MR_pic_Notebook.png" style="height:60px;"></a>
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<li><a href="https://2015.igem.org/Team:Marburg/Labbook">Lab Book</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Protocols">Protocols</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Bibliography">Bibliography</a></li>
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</ul>
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<li><a href="https://2015.igem.org/Team:Marburg/Team" class="first"><img src="https://static.igem.org/mediawiki/2015/1/1d/MR_pic_Team.png" style="height:60px;"></a>
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<ul>
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<li><a href="https://2015.igem.org/Team:Marburg/Members">Members</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Acknowledgement">Acknowledgement</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Attributions">Attributions</a></li>
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<li><a href="https://2015.igem.org/Team:Marburg/Gallery">Gallery</a></li>
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</ul>
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</li>
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<li><a href="https://2015.igem.org/Team:Marburg/Safety" class="first"><img src="https://static.igem.org/mediawiki/2015/6/6a/MR_pic_Safety.png" style="height:60px;"></a>
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<ul>
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                        <li><a href="https://2015.igem.org/Team:Marburg/Killswitch">KillSwitch Statistics</a></li>
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<div class="subpanel1">
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<div style="position:relative;bottom:0px">
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<div class="cont"><p style="font-size:26px;line-height:30px;">MAKE THE GUT A BETTER WORLD!</p></div>
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<div class="cont1">
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<p style="font-size:18px;">
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To tackle malnutrition and overconsumption of food represent one of the major challenges of humankind. The iGEM Team Marburg addresses these issues in a holistic approach by developing modular tools. Engineered, cell-based particles produce dietary supplements to alleviate malnutrition. A cell-free protein matrix with a functionalized surface targets specific nutrients to lower their concentration in the human gut. Furthermore, we engineer a contact-dependent delivery system that modifies the human gut microbial community. Taken together, we provide innovative solutions for improving and balancing nutrition at the interface of the human microbiome and gut.
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<p style="font-size:18px;line-height:120%;">We established minicells as a shuttle and production system as well as designed a modular device that makes bacteria minicell producers.</p>
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<div id="dsdesc" class="spdesc">
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<div class="cont" style="line-height:120%;">
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<p style="font-size:18px;line-height:120%;">We built a potentially cell free biofilm matrix that can be functionalized to serve customized purposes.</p>
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<div id="thdesc" class="spdesc">
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<div class="cont" style="line-height:120%;">
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<p style="font-size:18px;line-height:120%;">We characterized promotors in different hosts with various methods to get the best-studied BioBrick.</p>
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</div>
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</div>
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<div id="tcdesc" class="spdesc">
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<div class="cont" style="line-height:120%;">
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<p style="font-size:18px;line-height:120%;">We built a system to establish a niche to modify the human gut microbiome by inhibiting growth of proteobacteria.</p>
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</div>
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</div>
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</div>
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</div>
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<div>
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<a href="https://2015.igem.org/Team:Marburg/Minicells" title="Provide">
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<div id="pspanel" class="subpanel2"  onmouseover="chgtrans(this)">
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<img src="https://static.igem.org/mediawiki/2015/f/f2/MR_pic_FactPro.png" width="200px"/>
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<a href="https://2015.igem.org/Team:Marburg/Curli" title="Pick-up">
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<div id="dspanel" class="subpanel2">
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<img src="https://static.igem.org/mediawiki/2015/3/3a/MR_pic_FactPick.png" width="200px"/>
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<a href="https://2015.igem.org/Team:Marburg/CDI" title="Cut-off">
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<div id="tcpanel" class="subpanel2">
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<img src="https://static.igem.org/mediawiki/2015/2/24/MR_pic_FactCut.png" width="200px"/>
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<a href="https://2015.igem.org/Team:Marburg/Measurement" title="Measurement">
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<div id="thpanel" class="subpanel2">     
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<img src="https://static.igem.org/mediawiki/2015/e/e4/MR_pic_ButM.png" width="200px"/>
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</a>
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<p style="margin-top:10px;">
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<table>
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<a href="https://2015.igem.org/Team:Marburg/Results" title="Results" style="margin-top:50px;">
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<div class="subpanel3" style="width:205px;">
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<p style="padding-bottom:5px;"><i>Go to Results!</i></p>
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<a href="https://2015.igem.org/Team:Marburg/Medal Fulfillment" title="Medal" style="margin-top:50px;">
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<div class="subpanel3" style="width:305px;">
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<p style="padding-bottom:5px;"><i>Go to Medal Fulfillment!</i></p>
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</a>
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<a href="https://2015.igem.org/Team:Marburg/Parts" title="Parts" style="margin-top:50px;">
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<div class="subpanel3" style="width:225px;">
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<p style="padding-bottom:5px;"><i>Go to Parts!</i></p>
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</a>
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</td>
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                                <td>
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<a href="https://2015.igem.org/Team:Marburg/Safety" title="Safety" style="margin-top:50px;">
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<div class="subpanel3" style="width:215px;">
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<p style="padding-bottom:5px;"><i>Go to Safety!</i></p>
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</a>
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</td>
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</table>
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</p>
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<div style="margin-bottom:30px;margin-left:20px;">
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<a href="https://2015.igem.org/Team:Marburg/InterLab" title="ILS"><img src="https://static.igem.org/mediawiki/2015/a/a4/MR_pic_FactInter.png" class="subpanel4"/></a>
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<a href="https://2015.igem.org/Team:Marburg/Collaborations" title="Col"><img src="https://static.igem.org/mediawiki/2015/0/06/MR_pic_BUTCol.png" class="subpanel4"/></a>
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<a href="https://2015.igem.org/Team:Marburg/Design" title="FA"><img src="https://static.igem.org/mediawiki/2015/4/49/MR_pic_BUTfut.png" class="subpanel4"/></a>
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<a href="https://2015.igem.org/Team:Marburg/Practices" title="HP"><img src="https://static.igem.org/mediawiki/2015/4/47/MR_pic_BUThp.png" class="subpanel4"/></a>
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$(document).ready(function(){$('div #pspanel').mouseover(function(){div = $('#psdesc');div.fadeIn(1);}).mouseout(function(){div.fadeOut(1);});});
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$(document).ready(function(){$('div #thpanel').mouseover(function(){div = $('#thdesc');div.fadeIn(1);}).mouseout(function(){div.fadeOut(1);});});
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$(document).ready(function(){$('div #tcpanel').mouseover(function(){div = $('#tcdesc');div.fadeIn(1);}).mouseout(function(){div.fadeOut(1);});});
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<div style="position:absolute;text-align:center;z-index:2;background:#e0e0e0;line-height:150%;bottom:0px;padding-top:3px;margin-bottom:0px; padding-left:235px; padding-right:80px;min-height:60px;min-width:100%;max-width:100%;box-sizing:border-box;clear:both;"><!---->
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<div>
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<span style="margin-right:60px;">
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<img src="https://static.igem.org/mediawiki/2015/1/1d/MR_pic_syn.png" style="height:40px;padding:10px;"/>
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</span>
 +
<span>
 +
<img src="https://static.igem.org/mediawiki/2015/5/58/MR_pic_mpii.png" style="height:40px;padding:10px;"/>
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</span>
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<span style="margin-left:60px;">
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<img src="https://static.igem.org/mediawiki/2015/f/f0/MR_pic_unii.png" style="height:40px;padding:10px;"/>
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    <span style="font-size:8pt; color:white;"> iGEM Marburg - ZSM Karl-von-Frisch-Straße 16, D - 35043 Marburg</span>
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Latest revision as of 19:24, 18 September 2015

MAKE THE GUT A BETTER WORLD!

To tackle malnutrition and overconsumption of food represent one of the major challenges of humankind. The iGEM Team Marburg addresses these issues in a holistic approach by developing modular tools. Engineered, cell-based particles produce dietary supplements to alleviate malnutrition. A cell-free protein matrix with a functionalized surface targets specific nutrients to lower their concentration in the human gut. Furthermore, we engineer a contact-dependent delivery system that modifies the human gut microbial community. Taken together, we provide innovative solutions for improving and balancing nutrition at the interface of the human microbiome and gut.

We established minicells as a shuttle and production system as well as designed a modular device that makes bacteria minicell producers.

We built a potentially cell free biofilm matrix that can be functionalized to serve customized purposes.

We characterized promotors in different hosts with various methods to get the best-studied BioBrick.

We built a system to establish a niche to modify the human gut microbiome by inhibiting growth of proteobacteria.

Go to Results!

Go to Medal Fulfillment!

Go to Parts!

Go to Safety!

iGEM Marburg - ZSM Karl-von-Frisch-Straße 16, D - 35043 Marburg