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<p style="width:960px;text-align:center;color:#ac875d;font-size:30px;height:80px;line-height:80px;padding:0;margin:0;">The Manufacturing Plant of APeGs</p>
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Despite the fact that nowadays increasing attention has been paid to our health condition, there also exist more and more factors that can cause damage to our health, sometimes even making our life under great threat. <br/><br/>
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Great significance of extracting effective bioactive components from natural plants to benefit human beings has been gradually revealed, particularly when now we are showing more concerns to improving our health condition. We have found that compound Acyl phenylethyl alcohol glycosides in rehmannia can bring many benefits to our health, such as the regulation of neuroendocrine system, immunoregulation, anti-hepatitis and liver protection, energy boosting and anti-fatigue, anti-bacteria, anti-tumor, anti-radiation, ischemic myocardium protection, etc. <br/><br/>
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However, there also exist some difficulties of extracting natural elements from plants, such as the lack of natural plants and products. In order to ensure human beings a better life by gaining more products and lowering the price, we are expecting to increase the production of compound Acyl phenylethyl alcohol glycosides in rehmannia to get more effective bioactive components from limited products. In this way, we are approaching the noble goal of bringing more healthy benefits to our species. After having researched biosynthetic pathway of compound Acyl phenylethyl alcohol glycosides in rehmannia, we decide to introduce and adopt the gene that can increase the key enzyme activity in biosynthesis process to realize the goals of enriching synthetic metabolic pathways of natural bio-products and increasing the target product. 
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            <h2>Magthermo coli</h2>
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                    how does it <span>work?</span>
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                </h2>
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                <p>
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                    This summer we designed Magthermo coli——a platform for remote regulation of gene expression by electromagnetic signal.
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                    <img src="https://static.igem.org/mediawiki/2015/e/e1/OUC-China-home_receiver_regulator1.png" alt="" class="img-responsive">
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                    <h3 class="text-uppercase text-center">step 1</h3>
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                    <p>Our Magthermo coli contains 2 core components: <B>Magnetic Receiver & Thermosensitive Regulator.</B></p>
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                </div>
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                    <h3 class="text-uppercase text-center">step 2</h3>
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                    <p>Inducing with electromagnetic field, magnetic receiver will heat, raising the ambient temperature.</p>
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                    <h3 class="text-uppercase text-center">step 3</h3>
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                    <p>
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                        In response to the change of temperature, thermosensitive regulator will initiate downstream gene (GFP for example) expression.
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                    </p>
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            <h3 class="text-center index-headline">Magnetic <span>Receiver</span></h3>
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                        <p>
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                            For magnetic receiver,we chose <B>Ferritin</B>, the iron-storage protein in many organisms, which could synthesize ferric oxihydroxide core in its hollow protein shell. When exposed to electromagnetic field, the ferric oxihydroxide core will heat, raising the ambient temperature.
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                        </p>
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                        <p>
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                            In this section, we explored measurement techniques for the valuation of magnetism, biomineralization and protein concentration per cell.
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                        </p>
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                        <p><a href="https://2015.igem.org/Team:OUC-China/Project/Magnetic_Receiver" class="btn btn-primary" role="button">More details</a></p>
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                    </div>
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                </div>
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                    <img src="https://static.igem.org/mediawiki/2015/1/17/OUC-China-home-frritin.png" alt="" class="img-responsive">
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                </div>
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    <div class="container-fluid index-details2 index-details">
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        <div class="container">
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            <h3 class="text-center index-headline index-headline2">Thermosensitive <span>Regulator</span></h3>
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            <p class="text-center">For thermosensitive regulator，we chose <B>RNA thermometer</B> and designed a <B>thermosensitive T7 RNA polymerase.</B>  </p>
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                    <img src="https://static.igem.org/mediawiki/2015/b/b8/OUC-China-home-RNA.png" alt="" class="img-responsive">
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                </div>
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                        <p>
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                            <B>RNA thermometer</B> is a structured RNA which can expose SD sequences only at appropriate temperature.  In this section, we explored the measurement method to identify the efficiency of thermosensitive regulator under heat stress.
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                        </p>
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                        <p><a href="https://2015.igem.org/Team:OUC-China/Project/Thermosensitive_Regulator" class="btn btn-primary" role="button">More details</a></p>
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                        <p>
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                            <B>Thermosensitive T7 RNA polymerase</B> is a T7 RNA polymerase interrupted by a temperature-sensitive intein, which can self-splice at specific temperature and initiate the downstream signal.
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                        </p>
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                        <p><a href="https://2015.igem.org/Team:OUC-China/Project/Thermosensitive_Regulator" class="btn btn-primary" role="button">More details</a></p>
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                    <img src="https://static.igem.org/mediawiki/2015/4/4d/OUC-China-home-T7.png" alt="" class="img-responsive">
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Latest revision as of 01:50, 19 September 2015

<!DOCTYPE html> Team:OUC-China

how does it work?

This summer we designed Magthermo coli——a platform for remote regulation of gene expression by electromagnetic signal.

step 1

Our Magthermo coli contains 2 core components: Magnetic Receiver & Thermosensitive Regulator.

step 2

Inducing with electromagnetic field, magnetic receiver will heat, raising the ambient temperature.

step 3

In response to the change of temperature, thermosensitive regulator will initiate downstream gene (GFP for example) expression.

Magnetic Receiver

For magnetic receiver,we chose Ferritin, the iron-storage protein in many organisms, which could synthesize ferric oxihydroxide core in its hollow protein shell. When exposed to electromagnetic field, the ferric oxihydroxide core will heat, raising the ambient temperature.

In this section, we explored measurement techniques for the valuation of magnetism, biomineralization and protein concentration per cell.

More details

Thermosensitive Regulator

For thermosensitive regulator，we chose RNA thermometer and designed a thermosensitive T7 RNA polymerase.

RNA thermometer is a structured RNA which can expose SD sequences only at appropriate temperature. In this section, we explored the measurement method to identify the efficiency of thermosensitive regulator under heat stress.

More details

Thermosensitive T7 RNA polymerase is a T7 RNA polymerase interrupted by a temperature-sensitive intein, which can self-splice at specific temperature and initiate the downstream signal.

More details