Difference between revisions of "Team:Marburg/Projects"

 
(3 intermediate revisions by one other user not shown)
Line 327: Line 327:
 
<div style="position:relative;text-align:justify;z-index:1;background:white;font-size:13pt;line-height:150%;min-width:100%;max-width:100%;padding-top:132px; padding-left:235px; padding-right:80px;padding-bottom:70px;box-sizing: border-box;">
 
<div style="position:relative;text-align:justify;z-index:1;background:white;font-size:13pt;line-height:150%;min-width:100%;max-width:100%;padding-top:132px; padding-left:235px; padding-right:80px;padding-bottom:70px;box-sizing: border-box;">
  
−
<h1>Projects</h1>
+
<div style="z-index:1;text-align:left;padding-bottom:30px;text-align:center;"><img src="https://static.igem.org/mediawiki/2015/d/d6/MR_pic_Button_Overview03.png" style="height:60px;"/></div>
 +
 
 +
<style>
 +
/* Hover Shadow */
 +
 
 +
.shadow:hover {
 +
-webkit-box-shadow: 0px 0px 8px 6px rgba(255,143,69,1);
 +
-moz-box-shadow: 0px 0px 8px 6px rgba(255,143,69,1);
 +
box-shadow: 0px 0px 8px 6px rgba(255,143,69,1);
 +
border-radius:10px;
 +
}
 +
 
 +
.Anchor {
 +
    background-color:#FF8F45;
 +
    border-color:#FF8F45;
 +
    border-width:2px;
 +
    border-style:solid;
 +
    border-radius:7px;
 +
    padding:4px;
 +
    margin:8px;
 +
    width:175px;
 +
    text-align:center;
 +
}
 +
 
 +
.Anchor:hover {
 +
    opacity:0.6;
 +
    filter: alpha(opacity=60);
 +
}
 +
 
 +
A.class1 {color:white;}
 +
A.class1:link  {text-decoration: none; color: white;}
 +
A.class1:visited {text-decoration: none; color: white;}
 +
A.class1:hover {text-decoration: none; color: white;}
 +
A.class1:active {text-decoration: none; color: white;}
 +
 
 +
 
 +
A.class2 {color:#FF6600;}
 +
A.class2:link {text-decoration: none; color: #FF6600;}
 +
A.class2:visited {text-decoration: none; color: #FF6600;}
 +
A.class2:hover {text-decoration: none; color: #FF6600;}
 +
A.class2:active {text-decoration: none; color: #FF6600;}
 +
 
 +
 
 +
.anni{
 +
  display: block;
 +
  height: 80px; /*same height as header*/
 +
  margin-top: -80x; /*same height as header*/
 +
  visibility: hidden;
 +
}
 +
</style>
 +
 
 +
<center>
 +
<table>
 +
<td>
 +
<div class="Anchor" style="width:140px;"><a href="#Pro" class="class1">Provide</a></div>
 +
</td>
 +
<td>
 +
<div class="Anchor" style="width:140px;"><a href="#Pick" class="class1">Pick up</a></div>
 +
</td>
 +
<td>
 +
<div class="Anchor" style="width:160px;"><a href="#Cut" class="class1">Cut off</a></div>
 +
</td>
 +
</table>
 +
</center>
 +
 
 +
 
 +
<div style="position:relative;display:inline-block;padding:15px;background:#F8F8F8;border-style:solid;border-color:#FF8F45;border-width:2px;border-radius:10px;text-align:justify;font-size:13pt;line-height:150%;margin:10px;">
 +
<p>In Europe, everybody is talking about the world exhibition EXPO in Milano with the catchy title “Feeding the planet, Energy for Life”. To feed the world with a strongly growing population is no easy task and might be the most challenging one mankind ever faced. Especially in developing countries, undernutrition remains a big problem, even nowadays. Due to food shortage which is caused by high poverty, 166 million children worldwide are stunted from starvation which leads to a poor development impairing them for their whole lives [9].</p>
 +
<p>But not only malnutrition originating from an unequal distribution of food remains a problem. In many countries, we also face the opposite problem of wrong nutrition which leads to obesity. Today, nearly 1.9 billion people worldwide are obese [10] and this number is increasing every year.</p>
 +
<p>In our research on this topic and possible solutions, we learned that the composition of the human gut microbiota is strongly dependent on a person’s diet [4] and even on the physical conditions. To give an example, the amount of proteobacteria in the gut flora is much higher in overweight people [Shin et al. 2015] compared to people with normal body weight. Based on these facts, we developed the idea to influence the human gut in several ways.</p>
 +
<p>Many iGEM teams in previous years and also a lot of research groups often worked on a solution for one of the big problems that affect humanity today, either undernutrition or the overconsumption of food. We, the iGEM Team Marburg, want to find solutions for both sites of the coin. We want to show a novel, innovative and - most important - holistic approach for one of the biggest challenges of mankind. Our set ups might not be used in the near future but shall push innovations to a new level. Therefore, we aimed to contribute with a synthetic biology approach. To achieve this aim, we joined forces to proudly present you: <span style="color:#FF8F45;"><b>NUTRInity!</b></span></p>
 +
</div>
 +
 
 +
<span id="Pro" class="anni"></span>
 +
<h1>Provide</h1>
 +
<center>
 +
<div style="text-align:center;margin-bottom:20px;">
 +
<img src="https://static.igem.org/mediawiki/2015/d/d7/MR_pic_boxoverpic.png" width:990px;/>
 +
</div>
 +
</center>
 +
 
 +
<figure style="text-align:center;">
 +
<a href="https://2015.igem.org/Team:Marburg/Minicells"><img src="https://static.igem.org/mediawiki/2015/4/4e/MR_pic_button_prov.png" height="50px" class="shadow"/></a>
 +
</figure>
 +
 
 +
<span id="Pick" class="anni"></span>
 +
<h1>Pick up</h1>
 +
<center>
 +
<div style="text-align:center;margin-bottom:20px;">
 +
<img src="https://static.igem.org/mediawiki/2015/0/01/MR_pic_boxoverpick.png" width:990px;/>
 +
</div>
 +
</center>
 +
 
 +
<figure style="text-align:center;">
 +
<a href="https://2015.igem.org/Team:Marburg/Curli"><img src="https://static.igem.org/mediawiki/2015/f/fb/MR_pic_button_pick.png" height="50px" class="shadow"/></a>
 +
</figure>
 +
 
 +
<span id="Cut" class="anni"></span>
 +
<h1>Cut off</h1>
 +
<center>
 +
<div style="text-align:center;margin-bottom:20px;">
 +
<img src="https://static.igem.org/mediawiki/2015/1/12/MR_pic_boxovercut.png" width:990px;/>
 +
</div>
 +
</center>
 +
 
 +
<figure style="text-align:center;">
 +
<a href="https://2015.igem.org/Team:Marburg/CDI"><img src="https://static.igem.org/mediawiki/2015/a/a0/MR_pic_button_cut.png" height="50px" class="shadow"/></a>
 +
</figure>
 +
 
 +
<div style="position:relative;display:inline-block;padding:15px;background:#F8F8F8;border-style:solid;border-color:#FF8F45;border-width:2px;border-radius:10px;text-align:justify;font-size:13pt;line-height:150%;margin:10px;">
 +
<p>As all our projects are synthetic biology approaches, we are looking for ways to make biology easier to engineer and push synthetic biology projects forward. Therefore, we participated in the InterLab study and extend our work on this in a measurement study.</p> 
 +
<p>If you are interested in further information that inspired us, feel free to check our <a href="https://2015.igem.org/Team:Marburg/Bibliography" class="class2">bibliography</a>.</p>
 +
</div>
 +
 
 +
<div style="text-align:center;margin-bottom:30px;margin-top:20px;">
 +
<a href="https://2015.igem.org/Team:Marburg/InterLab"><img src="https://static.igem.org/mediawiki/2015/3/34/MR_pic_button_ilsn.png" height="50px" style="margin-right:20px;" class="shadow"/></a>
 +
 
 +
 
 +
<a href="https://2015.igem.org/Team:Marburg/Measurement"><img src="https://static.igem.org/mediawiki/2015/3/3a/MR_pic_Button_Measurement.png" height="50px" class="shadow"/></a>
 +
</div>
 +
 
  
−
<p>
 
−
This year, the iGEM Team Marburg decided to design, build and test various synthetic biological tools. These systems can be used in the future for different applications, from medical set ups to environmental improvements. In order to achieve a holistic approach, we are working in different subgroups that have different objectives, methods and applications. <br>
 
−
The first subgroup is looking into the possibility of generating non-propagating cell factories that are producing only a beneficial compound. Therefore, we are using different systems that encode the genetic information and we are building the cell factories.<br>
 
−
The second subgroup is currently working on a system to link our organism into a matrix that can enhance biochemical reactions. The idea is to use this as platform technology to link the organic and inorganic chemistry.<br>
 
−
Our third and last subgroup focuses on a delivery system for effector proteins in our model organism. Upon association of the donor strain, the system is activated to expose inhibitors or activators on its surface. These proteins are being absorbed by the recipient cell and generate an event there. <br>
 
−
We are also working on the interlab study within the iGEM competition...
 
−
</p>
 
 
</div>
 
</div>
  

Latest revision as of 16:04, 17 November 2015

Provide
Pick up
Cut off

In Europe, everybody is talking about the world exhibition EXPO in Milano with the catchy title “Feeding the planet, Energy for Life”. To feed the world with a strongly growing population is no easy task and might be the most challenging one mankind ever faced. Especially in developing countries, undernutrition remains a big problem, even nowadays. Due to food shortage which is caused by high poverty, 166 million children worldwide are stunted from starvation which leads to a poor development impairing them for their whole lives [9].

But not only malnutrition originating from an unequal distribution of food remains a problem. In many countries, we also face the opposite problem of wrong nutrition which leads to obesity. Today, nearly 1.9 billion people worldwide are obese [10] and this number is increasing every year.

In our research on this topic and possible solutions, we learned that the composition of the human gut microbiota is strongly dependent on a person’s diet [4] and even on the physical conditions. To give an example, the amount of proteobacteria in the gut flora is much higher in overweight people [Shin et al. 2015] compared to people with normal body weight. Based on these facts, we developed the idea to influence the human gut in several ways.

Many iGEM teams in previous years and also a lot of research groups often worked on a solution for one of the big problems that affect humanity today, either undernutrition or the overconsumption of food. We, the iGEM Team Marburg, want to find solutions for both sites of the coin. We want to show a novel, innovative and - most important - holistic approach for one of the biggest challenges of mankind. Our set ups might not be used in the near future but shall push innovations to a new level. Therefore, we aimed to contribute with a synthetic biology approach. To achieve this aim, we joined forces to proudly present you: NUTRInity!

Provide

Pick up

Cut off

As all our projects are synthetic biology approaches, we are looking for ways to make biology easier to engineer and push synthetic biology projects forward. Therefore, we participated in the InterLab study and extend our work on this in a measurement study.

If you are interested in further information that inspired us, feel free to check our bibliography.

iGEM Marburg - ZSM Karl-von-Frisch-Straße 16, D - 35043 Marburg