Difference between revisions of "Template:Team:TU Eindhoven/Overview HTML"

 
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<span class="tekst1BI">Dig Deeper</span><br />
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You have finished our short introduction. Continue with our project description.
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<span class="projectTitle">Clickable Outer Membrane Biosensors (COMBs)</span>
 
<span class="projectTitle">Clickable Outer Membrane Biosensors (COMBs)</span>
 
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<h2><span class="centreText"> - An aptamer-based approach to a universal and modular biosensor platform</span></h2>
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<h2><span class="centreText"> - An aptamer-based approach to a universal and modular biosensor platform </span></h2>
 
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Ground-breaking drug discoveries are at the forefront of society. <span class="tekst1B">The success rate of curing</span>, however, <span class="tekst1B">highly depends on an accurate and early diagnosis of disease</span> <image src="https://static.igem.org/mediawiki/2015/8/87/TU_Eindhoven_Ingeklapt.png" id="spoilerbutton1" class="spoilerbutton" />.<div class="spoiler" id="spoiler1">
 
Ground-breaking drug discoveries are at the forefront of society. <span class="tekst1B">The success rate of curing</span>, however, <span class="tekst1B">highly depends on an accurate and early diagnosis of disease</span> <image src="https://static.igem.org/mediawiki/2015/8/87/TU_Eindhoven_Ingeklapt.png" id="spoilerbutton1" class="spoilerbutton" />.<div class="spoiler" id="spoiler1">
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An illustrating example is intestinal cancer. The survival rate of patients diagnosed with intestinal cancer in the early stage is 90%, whereas the survival rate of patients diagnosed in the critical stage is a meagre 13% [1]. An accurate and early diagnosis saves lives.
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An illustrating example is intestinal cancer. The survival rate of patients diagnosed with intestinal cancer in the early stage is 90%, whereas the survival rate of patients diagnosed in the critical stage is a meagre 13% <a name="reft1" href="#ref1" class="textanchor">[1]</a>. An accurate and early diagnosis saves lives.
 
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An approach to diagnose disease is through the use of analytical instruments. Even though these instruments provide rich information which can lead to sound diagnoses, analytical instruments suffer from long processing and waiting times, as samples often need to be pre-treated and the instruments are frequently occupied. To overcome the long processing and waiting times, biosensors have been developed. These biosensors can be used on-site and are easy-to-use, but a universal approach in these biosensors is lacking. That is where we come in, as we have developed <span class="tekst1B">a universal membrane sensor platform for biosensors</span>, which we call Clickable Outer Membrane Biosensors (COMBs).
 
An approach to diagnose disease is through the use of analytical instruments. Even though these instruments provide rich information which can lead to sound diagnoses, analytical instruments suffer from long processing and waiting times, as samples often need to be pre-treated and the instruments are frequently occupied. To overcome the long processing and waiting times, biosensors have been developed. These biosensors can be used on-site and are easy-to-use, but a universal approach in these biosensors is lacking. That is where we come in, as we have developed <span class="tekst1B">a universal membrane sensor platform for biosensors</span>, which we call Clickable Outer Membrane Biosensors (COMBs).
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<div class="linkTxt"><span class="tekst1"><h3>Project Description</h3><br /><span class="tekst1">We dive a little deeper into the concept of COMBs in our Project Description. Click this image to read it!</span></div>
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<img class="linkImg" src="https://static.igem.org/mediawiki/2015/e/ef/TU_Eindhoven_Combs_Overview.png" alt="COMBs overview image"/>
 
<img class="linkImg" src="https://static.igem.org/mediawiki/2015/e/ef/TU_Eindhoven_Combs_Overview.png" alt="COMBs overview image"/>
 
<div class="linkTxt"><h3>COMBs</h3><br /><span class="tekst1">COMBs are the backbone of the modular biosensor platform we designed. Click this image to read more on COMBs.</span></div>
 
<div class="linkTxt"><h3>COMBs</h3><br /><span class="tekst1">COMBs are the backbone of the modular biosensor platform we designed. Click this image to read more on COMBs.</span></div>
 
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<img class="linkImg" src="https://static.igem.org/mediawiki/2015/f/f0/TU_Eindhoven_Expression_System.png" alt="Expression System"/>
 
<img class="linkImg" src="https://static.igem.org/mediawiki/2015/f/f0/TU_Eindhoven_Expression_System.png" alt="Expression System"/>
 
<div class="linkTxt"><span class="tekst1"><h3>Expression System</h3><br /><span class="tekst1">Read how we obtain bacteria expressing our non-natural COMBs here.</span></div>
 
<div class="linkTxt"><span class="tekst1"><h3>Expression System</h3><br /><span class="tekst1">Read how we obtain bacteria expressing our non-natural COMBs here.</span></div>
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<div class="linkTxt"><span class="tekst1"><h3>Experimental Approach</h3><br /><span class="tekst1">To test the viability of our COMBs, we have designed a few experiments. An overview of these experiments is shown on this page.</span></div>
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<div class="linkTxt"><span class="tekst1"><h3>Protocols</h3><br /><span class="tekst1">All the protocols we have used during our iGEM Project are listed on this page. These include cloning protocols but also protocols for our experiments.</span></div>
 
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<div class="linkTxt"><span class="tekst1"><h3>Expression System</h3><br /><span class="tekst1">To test the viability of our COMBs, we have designed a few experiments. An overview of these experiments is shown on this page.</span></div>
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<div class="linkTxt"><span class="tekst1"><h3>Timeline</h3><br /><span class="tekst1">During the iGEM competition, teams conduct research in a very limited timeframe. Visit this page to read how we managed to squeeze all wetwork in our summer.</span></div>
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<a href="#reft1" name="ref1">[1]</a> American Cancer Society. Colorectal Cancer Facts & Figures 2011-2013. Atlanta: American Cancer Society, 2011. <br />
 
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Latest revision as of 16:23, 22 November 2015






Clickable Outer Membrane Biosensors (COMBs)

- An aptamer-based approach to a universal and modular biosensor platform


Ground-breaking drug discoveries are at the forefront of society. The success rate of curing, however, highly depends on an accurate and early diagnosis of disease .
An illustrating example is intestinal cancer. The survival rate of patients diagnosed with intestinal cancer in the early stage is 90%, whereas the survival rate of patients diagnosed in the critical stage is a meagre 13% [1]. An accurate and early diagnosis saves lives.
An approach to diagnose disease is through the use of analytical instruments. Even though these instruments provide rich information which can lead to sound diagnoses, analytical instruments suffer from long processing and waiting times, as samples often need to be pre-treated and the instruments are frequently occupied. To overcome the long processing and waiting times, biosensors have been developed. These biosensors can be used on-site and are easy-to-use, but a universal approach in these biosensors is lacking. That is where we come in, as we have developed a universal membrane sensor platform for biosensors, which we call Clickable Outer Membrane Biosensors (COMBs).
Project Description

Project Description


We dive a little deeper into the concept of COMBs in our Project Description. Click this image to read it!
COMBs overview image

COMBs


COMBs are the backbone of the modular biosensor platform we designed. Click this image to read more on COMBs.
Expression System

Expression System


Read how we obtain bacteria expressing our non-natural COMBs here.
Epxerimental Approach

Experimental Approach


To test the viability of our COMBs, we have designed a few experiments. An overview of these experiments is shown on this page.
Protocols

Protocols


All the protocols we have used during our iGEM Project are listed on this page. These include cloning protocols but also protocols for our experiments.
Project Timeline

Timeline


During the iGEM competition, teams conduct research in a very limited timeframe. Visit this page to read how we managed to squeeze all wetwork in our summer.




[1] American Cancer Society. Colorectal Cancer Facts & Figures 2011-2013. Atlanta: American Cancer Society, 2011.