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                         <p>Understand our project in the smallest details and explore with us the world of CRISPR-dCas9.</p>
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Revision as of 14:17, 12 August 2015

EPFL 2015 iGEM bioLogic Logic Orthogonal gRNA Implemented Circuits EPFL 2015 iGEM bioLogic Logic Orthogonal gRNA Implemented Circuits

Bio LOGIC

Logic Orthogonal gRNA Implemented Circuits

Engineering transcriptional logic gates to program cellular behavior remains an important challenge for synthetic biology. Currently, genetic circuits reproducing digital logic are limited in scalability and robustness by output discrepancies and crosstalk between transcriptional pathways. We propose to address these issues using RNA-guided dCas9 fused to a transcription activation domain as a programmable transcription factor.

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Project

Background

Discover what brought us the idea of our project. Starting from the boolean logic and ending with the complete explication of a biologic logic gate.

Description

Understand our project in the smallest details and explore the world of CRISPR-dCas9 with us.

Applications

Need a biosensor? Want a bacteria that could depollute a lake? Here are a few examples of how you could apply our technology for your own designs

Modelling

Having a robust system is the key to devise a new concept and testing it in silico before commanding the expensive parts

EPFL 2015 iGEM bioLogic Logic Orthogonal gRNA Implemented Circuits