Team:SZU China

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Part Documentation

Nowadays,Bladder cancer is one of the most urologic tumours in the world. However, the conventional therapy of cancer such as chemotherapy and radiation,have focused on mass cell killing without specific targeting and often cause side effects and frequent failures. Therefore,targeted and specific therapeutic strategy based on human cancer gene therapy turns out to be a promising approach to the treatment of bladder cancer.

Here we present the Synthesizing AND GATE genetic circuit based on UAA (Unnatural Amino Acid) and Orthogonal system that will detect and induce  the apoptosis of bladder cancer cell. The system encompasses two parts. One is the synthesizing gene circuit which only operates in bladder cancer cells that behaves as a logical AND gate on two input promoters.The AND gate activates an output that produces a cellular phenotype only when both promoters are capable of driving gene expression in the tested cell lines. Another part is to insert the synthesized unnatural amino acids in the bladder cancer cell to continue the protein translation at TAG(amber mutation) in order to activate the effectors. This methodology is based on the orthogonal system which enable the unnatural amino acids to generate protein without affecting other parts’ work. As a result, the output gene will hinder the tumour growth and induce apoptosis.

Note

Note that parts must be documented on the Registry. This page serves to showcase the parts you have made. Future teams and other users and are much more likely to find parts by looking in the Registry than by looking at your team wiki.

Adding parts to the registry

You can add parts to the Registry at our Add a Part to the Registry link.

We encourage teams to start completing documentation for their parts on the Registry as soon as you have it available. The sooner you put up your parts, the better you will remember all the details about your parts. Remember, you don't need to send us the DNA sample before you create an entry for a part on the Registry. (However, you do need to send us the DNA sample before the Jamboree. If you don't send us a DNA sample of a part, that part will not be eligible for awards and medal criteria.)