Difference between revisions of "Team:Harvard BioDesign"

 
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               <span class="harvardLogo"><a href="https://2015.igem.org/Team:Harvard_BioDesign"><img src="https://static.igem.org/mediawiki/2015/9/94/HarvardBioDesign2015Logo2.png"alt="Harvard Logo" style="width:212px;height:144px;"/></a> </span>
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               <span class="harvardLogo"><a href="https://2015.igem.org/Team:Harvard_BioDesign"><img src="https://static.igem.org/mediawiki/2015/9/94/HarvardBioDesign2015Logo2.png"alt="Harvard Logo" style="width:275px;height:200px;margin-left:-50px;"/></a></span>
 
             <!-- <h1 id="title">Harvard BioDesign 2015</h1>-->
 
             <!-- <h1 id="title">Harvard BioDesign 2015</h1>-->
 
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<h4> Content </h4>
 
<h4> Content </h4>
 
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                 <li><a href="#top" id="top-link" class="skel-layers-ignoreHref"><span class="icon fa-home">Welcome</span></a></li>
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                 <li><a href="https://2015.igem.org/Team:Harvard_BioDesign#top" id="top-link" class="skel-layers-ignoreHref"><span class="icon fa-home">Welcome</span></a></li>    
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                 <li><a href="#sitemap" id="sitemap-link" class="skel-layers-ignoreHref"><span class="icon fa-user">Site Map</span></a></li>
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                 <li><a href="https://2015.igem.org/Team:Harvard_BioDesign#teampage" id="teampage-link" class="skel-layers-ignoreHref"><span class="icon fa-user">Page Overviews</span></a></li>
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                <li><a href="#teampage" id="teampage-link" class="skel-layers-ignoreHref"><span class="icon fa-user">Page Overviews</span></a></li>
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<li><a class="curPage" href="https://2015.igem.org/Team:Harvard_BioDesign">Home</a></li>  
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            <ul>
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<li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Project">Project</a></li>  
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                <li><a class="curPage" href="https://2015.igem.org/Team:Harvard_BioDesign">Home</a></li>
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<li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Results">Results</a></li>  
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                <li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Team">Team</a></li>
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<li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Notebook">Notebook</a></li>  
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                <li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Project">Project</a></li>
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                <li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Results">Results</a></li>
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<li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Practices">Practices</a></li>  
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                <li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Notebook">Notebook</a></li>
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                <li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Parts">Parts</a></li>
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<li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Collaborations">Collaborations</a></li>
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                <li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Collaborations">Collaborations</a></li>
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<li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Team">Team</a></li>
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                <li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Attributions">Attributions</a></li>
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<li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Attributions">Attributions</a></li>  
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                <li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Practices">Practices</a></li>
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                <li><a href="https://2015.igem.org/Team:Harvard_BioDesign/Safety">Safety</a></li>
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               <header>
 
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                <h2 class="alt">Welcome to the <strong>Harvard BioDesign 2015</strong> wiki!</h2><br/>
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              <img src="https://static.igem.org/mediawiki/2015/9/94/HarvardBioDesign2015Logo2.png"alt="Harvard Logo"/>
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                <p>The "official" place where flocculation happens and llamas are appreciated.</p>
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<img src="https://static.igem.org/mediawiki/2015/3/38/HarvardLlamaoutline.png" alt="Email Logo" style="width:127px;height:150px;">
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               </header>
 
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  <p>Colon cancer is the second leading cause of cancer death in the United States. Each year, almost 140,000 people are diagnosed with colon cancer, and 50,000 people die from the disease<sup>1</sup>. Diagnosis and treatment often require invasive procedures, including colonoscopies and surgery. Less invasive treatments such as chemotherapy cause unpleasant side effects. We turn to synthetic biology to develop a better colon cancer therapy. An ideal cell-based therapy would have two significant components: a way to kill cancer cells, and a way to specifically target them. In our quest to find a way to specifically target cancer cells, we found that the problem of controlling a cell’s interaction with its physical environment extended beyond cancer therapy into a myriad of biological contexts. Harvard iGEM 2015 focuses on building a platform for controlling specific bacterial adhesion in a variety of biological settings, including colon cancer therapy.
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            Curious?<br/>
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<a href="#sitemap" style="font-family:'Lato';color:#C1E8DE;font-size:23px;"><h4 class="mid" style="color:#000;">Start Here</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
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<a href="#top" style="font-family:'Lato';color:#9DE8BD;font-size:23px;"><h4 class="mid" style="font-size:90%;">Start Here</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
 
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                <h2>How to navigate our site</h2>
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<img src="https://static.igem.org/mediawiki/2015/8/85/Harvard_2015_Project.png" alt="Project Logo" style="width:200px;height:200px;"/>
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<header><h3>Learn what we are all about. Here you can learn how we set up and conducted our research.</h3></header>
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              <h6>Here is an easy guide to finding information on our wiki site. On the top of every page you will see a flask. When you click on it, it will open up the main navigation menu. The top section includes links of the different sections on the current page. The lower links are to switch to a new page. You can see all the pages by looking at our site map listed below. You can also get a brief idea of what you'll find on each page by scrolling down.</h6>
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              <br/>
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              <p><a href="https://static.igem.org/mediawiki/2015/c/ce/Harvard2015SiteMap.png" target="_blank">Click Here</a> to see our site map</p>
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<section id="teampage" class="four"><div class="container"></div>
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<img src="https://static.igem.org/mediawiki/2015/e/e2/Harvard2015_Team.png" alt="Team Logo" style="width:200px;height:200px;"/></a>  
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<header><h3>See who participated on this year’s iGEM team.</h3></header>
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<footer>
 
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Team" style="font-family:'Lato';color:#CDFCFF;"><h4 class="mid" style="color:#000;">Team</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Project" style="font-family:'Lato';color:#ADFFB7;"><h4 class="mid">Project</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
 
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<img src="https://static.igem.org/mediawiki/2015/7/74/Harvard2015_Accomplish.png" alt="Accomplish Logo" style="width:200px;height:200px;"/></a>
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<header><h3>Learn what we are all about. Here you can learn how we set up and conducted our research.</h3></header>
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<header><h3>Find our major accomplishments here and where we plan to go with them.</h3></header>
 
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Results" style="font-family:'Lato';color:#E0FFD5;"><h4 class="mid">Results</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
 
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<img src="https://static.igem.org/mediawiki/2015/4/40/Harvard2015_Results.png" alt="Results Logo" style="width:200px;height:200px;"/></a>  
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<img src="https://static.igem.org/mediawiki/2015/5/53/Harvard2015_Notebook.png" alt="Notebook Logo" style="width:200px;height:200px;"/></a>
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<header><h3>Find our major accomplishments here and where we plan to go with them.</h3></header>
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<header><h3>The story of our hard work.</h3></header>
 
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Results" style="font-family:'Lato';color:#E0FFD5;"><h4 class="mid" style="color:#000;">Results</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Notebook" style="font-family:'Lato';color:#E1FFEE;"><h4 class="mid">Notes</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
 
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<img src="https://static.igem.org/mediawiki/2015/b/b1/Harvard2015_Parts.png" alt="Parts Logo" style="width:200px;height:200px;"/></a>  
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<img src="https://static.igem.org/mediawiki/2015/b/b1/Harvard2015_Parts.png" alt="Parts Logo" style="width:200px;height:200px;"/></a>
 
<header><h3>View the parts we created.</h3></header>
 
<header><h3>View the parts we created.</h3></header>
 
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Parts" style="font-family:'Lato';color:#B9FFEE;"><h4 class="mid" style="color:#000;">Parts</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Parts" style="font-family:'Lato';color:#B9FFEE;"><h4 class="mid">Parts</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
 
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<img src="https://static.igem.org/mediawiki/2015/5/53/Harvard2015_Notebook.png" alt="Notebook Logo" style="width:200px;height:200px;"/></a>  
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<img src="https://static.igem.org/mediawiki/2015/c/c8/Harvard2015_Practices.png" alt="Practices Logo" style="width:200px;height:200px;"/></a>
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<header><h3>The story of our hard work.</h3></header>
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<header><h3>A guide to how to take research to the next level.</h3></header>
 
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Notebook" style="font-family:'Lato';color:#E1FFEE;"><h4 class="mid" style="color:#000;">Notes</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Practices" style="font-family:'Lato';color:#C1E8DE;font-size:23px;"><h4 class="mid">Practices</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
 
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<img src="https://static.igem.org/mediawiki/2015/8/82/Harvard2015_Collabs.png" alt="Collabs Logo" style="width:200px;height:200px;"/></a>  
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<img src="https://static.igem.org/mediawiki/2015/4/44/Harvard2015_Safety.png" alt="Safety Logo" style="width:200px;height:200px;"/></a>
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<header><h3>Outreach to our fellow iGEMers.</h3></header>
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<header><h3>Safety is what really matters.</h3></header>
 
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Collaborations" style="font-family:'Lato';color:#9DE3E8;"><h4 class="mid" style="color:#000;">Collabs</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Safety" style="font-family:'Lato';color:#9DE8BD;"><h4 class="mid">Safety</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
 
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<img src="https://static.igem.org/mediawiki/2015/c/c8/Harvard2015_Practices.png" alt="Practices Logo" style="width:200px;height:200px;"/></a>  
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<img src="https://static.igem.org/mediawiki/2015/8/82/Harvard2015_Collabs.png" alt="Collabs Logo" style="width:200px;height:200px;"/></a>
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<header><h3>A guide to how to take research to the next level.</h3></header>
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<header><h3>Outreach to our fellow iGEMers.</h3></header>
 
<footer>
 
<footer>
 
<div id="buttonbox">
 
<div id="buttonbox">
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Practices" style="font-family:'Lato';color:#C1E8DE;font-size:23px;"><h4 class="mid" style="color:#000;">Practices</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Collaborations" style="font-family:'Lato';color:#9DE3E8;"><h4 class="mid">Collabs</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
 
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<section id="teampage" class="nine">
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<img src="https://static.igem.org/mediawiki/2015/4/44/Harvard2015_Safety.png" alt="Safety Logo" style="width:200px;height:200px;"/></a>  
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<div class="container"></div>
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<header><h3>Safety is what really matters.</h3></header>
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<img src="https://static.igem.org/mediawiki/2015/e/e2/Harvard2015_Team.png" alt="Team Logo" style="width:200px;height:200px;"/></a>
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<header><h3>See who participated on this year’s iGEM team.</h3></header>
 
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Safety" style="font-family:'Lato';color:#9DE8BD;"><h4 class="mid" style="color:#000;">Safety</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Team" style="font-family:'Lato';color:#CDFCFF;"><h4 class="mid">Team</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
 
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<img src="https://static.igem.org/mediawiki/2015/1/1b/Harvard2015_Attributions.png" alt="Attributions Logo" style="width:200px;height:200px;"/></a>  
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<img src="https://static.igem.org/mediawiki/2015/1/1b/Harvard2015_Attributions.png" alt="Attributions Logo" style="width:200px;height:200px;"/></a>
 
<header><h3>A shoutout to those who made us possible.</h3></header>
 
<header><h3>A shoutout to those who made us possible.</h3></header>
 
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Attributions" style="font-family:'Lato';color:#C1E8C5;"><h4 class="mid" style="color:#000;">Thanks</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
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<a href="https://2015.igem.org/Team:Harvard_BioDesign/Attributions" style="font-family:'Lato';color:#C1E8C5;"><h4 class="mid">Thanks</h4><img class="rot" src="https://static.igem.org/mediawiki/2015/6/64/Harvard_Circle_Outside.png"/></a>
 
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         <!-- Copyright -->
 
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             <li><a href="https://static.igem.org/mediawiki/2015/c/ce/Harvard2015SiteMap.png" target="_blank">Site Map</a></li><li>Site template designed by: <a href="http://html5up.net">HTML5 UP</a></li><h5>
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             </li><li>Site template designed by: <a href="http://html5up.net">HTML5 UP</a></li><h5>
 
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                <h2>About our project</h2>
 
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              <p>Our team is engineering <i>E. coli</i> to bind to colon cancer cells through the use of their type I pili, which are hair-like appendages
 
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              that have an adhesive domain. Naturally, the strains in <i>E. coli</i> that produce pili bind to alpha-D-mannose, which can cause urinary tract infections.
 
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              However, our team is altering a non-harmful strain to produce pili using a modified Fim gene in order to localize the bacteria as a tool. For treatment of cancer,
 
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              once the bacteria are localized on the cells, the next step is to make them <E. coli</i> capable of producing a concentrated toxin or to administer a therapeutic.
 
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              Other potential applications for our <i>E. coli </i> include water pollution clean up through methods such as flocculation and targeting areas through GFP.</p>
 
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                      <h3>Ipsum Feugiat</h3>
 
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                      <h3>Magna Nullam</h3>
 
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                      <h3>Dolor Penatibus</h3>
 
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                      <h3>Orci Convallis</h3>
 
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Latest revision as of 03:18, 19 September 2015


Prologue by HTML5 UP

Harvard Logo

Colon cancer is the second leading cause of cancer death in the United States. Each year, almost 140,000 people are diagnosed with colon cancer, and 50,000 people die from the disease1. Diagnosis and treatment often require invasive procedures, including colonoscopies and surgery. Less invasive treatments such as chemotherapy cause unpleasant side effects. We turn to synthetic biology to develop a better colon cancer therapy. An ideal cell-based therapy would have two significant components: a way to kill cancer cells, and a way to specifically target them. In our quest to find a way to specifically target cancer cells, we found that the problem of controlling a cell’s interaction with its physical environment extended beyond cancer therapy into a myriad of biological contexts. Harvard iGEM 2015 focuses on building a platform for controlling specific bacterial adhesion in a variety of biological settings, including colon cancer therapy.

Project Logo

Learn what we are all about. Here you can learn how we set up and conducted our research.

Accomplish Logo

Find our major accomplishments here and where we plan to go with them.

Notebook Logo

The story of our hard work.

Parts Logo

View the parts we created.

Practices Logo

A guide to how to take research to the next level.

Safety Logo

Safety is what really matters.

Collabs Logo

Outreach to our fellow iGEMers.

Team Logo

See who participated on this year’s iGEM team.

Attributions Logo

A shoutout to those who made us possible.