Difference between revisions of "Team:LASATX"

 
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<li class="menu-item"><a href="https://2015.igem.org/Team:LASATX/Medal Recs">Medals</a></li>
 
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Thousands of people are injured from unintentional carbon monoxide poisoning each year. CO causes anoxia when inhaled, a condition characterized by severe deprivation of oxygen to the brain and blood; further cognitive impairments may develop as well. As this toxic, odorless gas can be produced by fuel-emitting vehicles or kitchen appliances, CO detectors are essential in every domestic and industrial setting.
 
  
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Thousands of people are injured from unintentional carbon monoxide poisoning each year. CO causes anoxia when inhaled, a condition characterized by severe deprivation of oxygen to the brain and blood; further cognitive impairments may develop as well. As this toxic, odorless gas can be produced by fuel-emitting vehicles or kitchen appliances, CO detectors are essential in every domestic and industrial setting.
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Carbon monoxide (CO) is a toxic colorless and odorless gas that results in thousands of fatalities a year, yet most detectors are based upon sight and sound that exclude the blind and the deaf. Furthermore, current sensors rely upon upon the presence of electricity and power, and are thus unable to act in scenarios of natural disasters when CO leaks are most likely.
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Most commercially available CO detectors change color and sound alarms in the presence of a deleterious accumulation of the substance. However, while this may provide protection to some, we wanted to extend this system of defense to those who might not benefit from this mechanism (e.g. those who are blind and deaf). Our project aims to create a CO sensor that can give a fragrance to this odorless gas and thus warn those nearby through their sense of smell.
 
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This project introduces a CO-sensing mechanism into E.coli using a CooA transcription activator and corresponding pCooF promoter to regulate the expression of a methyl salicylate pathway (pchBA and BSMT genes). The pathway converts the endogenous molecule chorismate into salicylic acid and then methyl salicylate, producing a wintergreen smell in the presence of CO. This CO sensor has implications for not only the disabled, but also commercial use in cases of natural disaster due to its cost efficiency and transportability.
  
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We introduced a carbon monoxide-sensing mechanism and a wintergreen fragrance (methyl salicylate) pathway into E. coli so that in the presence of CO, our engineered bacteria will emit a wintergreen smell. With a CO-induced wintergreen pathway, we hope to provide a working CO sensor that is useful not only to the general public but especially to those who find current CO sensors impractical.
 
 
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<h1><center>iGEM 2015 Results</center></h1>
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<p> Gold medalist </p>
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<p> Nominated for Best Wiki, High School </p>
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<p> Nominated for Best Poster, High School </p>
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<p> Nominated for Best Presentation, High School </p>
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<p> (For more information, click <a href = "https://2015.igem.org/Results">here </a>) </p>
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Latest revision as of 01:22, 2 October 2015




Liberal Arts and Science Academy High School

Thousands of people are injured from unintentional carbon monoxide poisoning each year. CO causes anoxia when inhaled, a condition characterized by severe deprivation of oxygen to the brain and blood; further cognitive impairments may develop as well. As this toxic, odorless gas can be produced by fuel-emitting vehicles or kitchen appliances, CO detectors are essential in every domestic and industrial setting.

Carbon monoxide (CO) is a toxic colorless and odorless gas that results in thousands of fatalities a year, yet most detectors are based upon sight and sound that exclude the blind and the deaf. Furthermore, current sensors rely upon upon the presence of electricity and power, and are thus unable to act in scenarios of natural disasters when CO leaks are most likely.

This project introduces a CO-sensing mechanism into E.coli using a CooA transcription activator and corresponding pCooF promoter to regulate the expression of a methyl salicylate pathway (pchBA and BSMT genes). The pathway converts the endogenous molecule chorismate into salicylic acid and then methyl salicylate, producing a wintergreen smell in the presence of CO. This CO sensor has implications for not only the disabled, but also commercial use in cases of natural disaster due to its cost efficiency and transportability.

iGEM 2015 Results

Gold medalist

Nominated for Best Wiki, High School

Nominated for Best Poster, High School

Nominated for Best Presentation, High School


(For more information, click here )