Difference between revisions of "Team:SZU China"
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<link href="https://2015.igem.org/Template:SZU_China/Playground/custom/CSS?action=raw&ctype=text/css" rel="stylesheet"> | <link href="https://2015.igem.org/Template:SZU_China/Playground/custom/CSS?action=raw&ctype=text/css" rel="stylesheet"> | ||
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| − | <div class="inner-content"> | + | <div class="inner-content" style="background-color:#39f; height:600px;"> |
<div class="texts"> | <div class="texts"> | ||
<p id="heading">Bladder Cancer Sniper</p> | <p id="heading">Bladder Cancer Sniper</p> | ||
<p id="brief">Combine Biological Unnatural Amino Acid（UAA）Orthogonal | <p id="brief">Combine Biological Unnatural Amino Acid（UAA）Orthogonal | ||
<br>genectical system with logic "AND" gate gene circuit | <br>genectical system with logic "AND" gate gene circuit | ||
| − | <br>to | + | <br>to kill bladder cancer cells precisely</p> |
</div> | </div> | ||
<div class="banner"> | <div class="banner"> | ||
| − | <img src="https://static.igem.org/mediawiki/2015/7/79/SZU_China_banner.png"> | + | <img src="https://static.igem.org/mediawiki/2015/7/79/SZU_China_banner.png" style="position:absolute;right:10%;top:169px;"> |
| + | <img src="https://static.igem.org/mediawiki/2015/3/30/SZU_China_target.png" id="xz"> | ||
</div> | </div> | ||
</div> | </div> | ||
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<div class="md-modal md-effect-1" id="modal-1"> | <div class="md-modal md-effect-1" id="modal-1"> | ||
<div class="md-content" style="background-color:#39f;width:630px;"> | <div class="md-content" style="background-color:#39f;width:630px;"> | ||
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<h4 style="font-size:1.6em;text-align:center">Why is sniper?</h4> | <h4 style="font-size:1.6em;text-align:center">Why is sniper?</h4> | ||
<p>Sniper means to shoot the target precisely. Distinguish from the conventional therapy such as radiotherapy and chemical therapy, the synthesizing system we construct target bladder cancer cell specifically without harming the healthy cells.</p> | <p>Sniper means to shoot the target precisely. Distinguish from the conventional therapy such as radiotherapy and chemical therapy, the synthesizing system we construct target bladder cancer cell specifically without harming the healthy cells.</p> | ||
| − | <button style="position:absolute;left:1px;border-radius:0 80px 80px 0;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page1',' | + | <button style="position:absolute;left:1px;border-radius:0 80px 80px 0;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page1','page5')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;"><</p></button> |
<button style="position:absolute;right:1px;border-radius:80px 0 0 80px;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page1','page2')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;">></p></button> | <button style="position:absolute;right:1px;border-radius:80px 0 0 80px;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page1','page2')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;">></p></button> | ||
<p style="font-size:0.8em;text-align:center;color:#ddd;font-weight:100;position:relative;top:42px;">1/6</p> | <p style="font-size:0.8em;text-align:center;color:#ddd;font-weight:100;position:relative;top:42px;">1/6</p> | ||
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<h4 style="font-size:1.6em;text-align:center">Background</h4> | <h4 style="font-size:1.6em;text-align:center">Background</h4> | ||
<p>Nowadays,bladder cancer is one of the urologic tumours in the world. However, the conventional therapy have focused on mass cell killing without specific targeting. Therefore, targeted and specific therapeutic strategy turns out to be a promising approach to the treatment of bladder cancer.</p> | <p>Nowadays,bladder cancer is one of the urologic tumours in the world. However, the conventional therapy have focused on mass cell killing without specific targeting. Therefore, targeted and specific therapeutic strategy turns out to be a promising approach to the treatment of bladder cancer.</p> | ||
| + | <a href="https://2015.igem.org/Team:SZU_China/Background" style="color:#eee;text-align:center;font-size:0.8em;padding:40px;">learn more>></a> | ||
<button style="position:absolute;left:1px;border-radius:0 80px 80px 0;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page2','page1')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;"><</p></button> | <button style="position:absolute;left:1px;border-radius:0 80px 80px 0;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page2','page1')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;"><</p></button> | ||
<button style="position:absolute;right:1px;border-radius:80px 0 0 80px;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page2','page3')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;">></p></button> | <button style="position:absolute;right:1px;border-radius:80px 0 0 80px;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page2','page3')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;">></p></button> | ||
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<div id="page3" style="display:none;"> | <div id="page3" style="display:none;"> | ||
<img src="https://static.igem.org/mediawiki/2015/6/68/SZU_China_QV4.png"> | <img src="https://static.igem.org/mediawiki/2015/6/68/SZU_China_QV4.png"> | ||
| − | <h4 style="font-size:1.6em;text-align:center"> | + | <h4 style="font-size:1.6em;text-align:center">AND GATE</h4> |
| − | <p> | + | <p>AND gate is the synthesizing gene circuit which only operates in bladder cancer cells that behaves as a logical AND gate on two input promoters. It activates an output only when both promoters are capable of driving gene expression in the tested cell lines.</p> |
| − | <a href="https://2015.igem.org/Team:SZU_China/ | + | <a href="https://2015.igem.org/Team:SZU_China/Design" style="color:#eee;text-align:center;font-size:0.8em;padding:40px;">learn more>></a> |
<button style="position:absolute;left:1px;border-radius:0 80px 80px 0;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page3','page2')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;"><</p></button> | <button style="position:absolute;left:1px;border-radius:0 80px 80px 0;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page3','page2')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;"><</p></button> | ||
<button style="position:absolute;right:1px;border-radius:80px 0 0 80px;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page3','page4')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;">></p></button> | <button style="position:absolute;right:1px;border-radius:80px 0 0 80px;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page3','page4')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;">></p></button> | ||
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<div id="page4" style="display:none;"> | <div id="page4" style="display:none;"> | ||
<img src="https://static.igem.org/mediawiki/2015/0/09/SZU_China_QV5.png"> | <img src="https://static.igem.org/mediawiki/2015/0/09/SZU_China_QV5.png"> | ||
| − | <h4 style="font-size:1.6em;text-align:center;"> | + | <h4 style="font-size:1.6em;text-align:center;">Orthogonal System</h4> |
| − | <p> | + | <p>Parallel and independent orthogonal system is one of the foundations of synthetic biology with no or little cross with the natural biological system. The orthogonal system enable the unnatural amino acids to generate protein without affecting other parts'work.</p> |
| − | <a href="https://2015.igem.org/Team:SZU_China/ | + | <a href="https://2015.igem.org/Team:SZU_China/Design" style="color:#eee;text-align:center;font-size:0.8em;padding:40px;">learn more>></a> |
<button style="position:absolute;left:1px;border-radius:0 80px 80px 0;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page4','page3')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;"><</p></button> | <button style="position:absolute;left:1px;border-radius:0 80px 80px 0;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page4','page3')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;"><</p></button> | ||
<button style="position:absolute;right:1px;border-radius:80px 0 0 80px;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page4','page5')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;">></p></button> | <button style="position:absolute;right:1px;border-radius:80px 0 0 80px;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page4','page5')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;">></p></button> | ||
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<img src="https://static.igem.org/mediawiki/2015/1/18/SZU_China_QV6.png"> | <img src="https://static.igem.org/mediawiki/2015/1/18/SZU_China_QV6.png"> | ||
<h4 style="font-size:1.6em;text-align:center">Result</h4> | <h4 style="font-size:1.6em;text-align:center">Result</h4> | ||
| − | <p> | + | <p>The result shows that the expression of the output reporter gene being detected in bladder cancer cells were significantly higher that of other cell types, which suggests our circuit can selectively perform its function in bladder cancer cells. Our orthogonal system is also verified to work in high efficiency since it only demonstrated significant activity in bladder cancer cells with Ack.</p> |
<a href="https://2015.igem.org/Team:SZU_China/Result" style="color:#eee;text-align:center;font-size:0.8em;padding:40px;">learn more>></a> | <a href="https://2015.igem.org/Team:SZU_China/Result" style="color:#eee;text-align:center;font-size:0.8em;padding:40px;">learn more>></a> | ||
<button style="position:absolute;left:1px;border-radius:0 80px 80px 0;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page5','page4')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;"><</p></button> | <button style="position:absolute;left:1px;border-radius:0 80px 80px 0;width:21px;height:42px;padding:59px 29.5px;" onclick="next('page5','page4')"><p style="font-size:5em;position:relative;left:-21px;top:-63px;"><</p></button> | ||
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</body> | </body> | ||
</html> | </html> | ||
| + | {{Template:SZU_China/Playground/footer}} | ||
Latest revision as of 22:00, 18 September 2015
Bladder Cancer Sniper
Combine Biological Unnatural Amino Acid（UAA）Orthogonal
genectical system with logic "AND" gate gene circuit
to kill bladder cancer cells precisely
Quick View
Why is sniper?
Sniper means to shoot the target precisely. Distinguish from the conventional therapy such as radiotherapy and chemical therapy, the synthesizing system we construct target bladder cancer cell specifically without harming the healthy cells.
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