Difference between revisions of "Team:ETH Zurich/Modeling/Reaction-diffusion"

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<h1>Full Model</h1>
 
<h1>Full Model</h1>
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<h2>1D model in MATLAB</h2>
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<h2>3D model in COMSOL with reaction-diffusion</h2>
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<h3>Four cases</h3>
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<h3>Assumptions</h3>
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<ul>
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<li>Target mammalian cell located in the center of the well</li>
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<li>Constant rate of lactate production</li>
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<li><i>E. coli</i> bound to target cell abstracted into homogeneous layer around target cell</li>
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<li>Lactate represented as two states: inside and outside <i>E. coli</i>, denoted $Lac_int$ and $Lac_ext$, respectively</li>
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<ul>
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<li>$Lac_int$ can diffuse freely through medium and membranes, $Lac_ext$ cannot</li>
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<li>Use to simulate different import and export rates of lactate into <i>E. coli</i></li>
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</ul>
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</ul>
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<h3>Results</h3>
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<h2>1D and 2D COMSOL models</h2>
  
 
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Revision as of 15:52, 18 August 2015

"What I cannot create I do not understand."
- Richard Feynmann

Full Model

1D model in MATLAB

3D model in COMSOL with reaction-diffusion

Four cases

Assumptions

  • Target mammalian cell located in the center of the well
  • Constant rate of lactate production
  • E. coli bound to target cell abstracted into homogeneous layer around target cell
  • Lactate represented as two states: inside and outside E. coli, denoted $Lac_int$ and $Lac_ext$, respectively
    • $Lac_int$ can diffuse freely through medium and membranes, $Lac_ext$ cannot
    • Use to simulate different import and export rates of lactate into E. coli

Results

1D and 2D COMSOL models