Difference between revisions of "Team:HSNU-TAIPEI/Project/Mercury"
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<h2><font color="#008b8b"> ✡ Introduction</font></h2> | <h2><font color="#008b8b"> ✡ Introduction</font></h2> | ||
| − | <p> (1)為何偵測此毒物? </p> | + | <p><font face="Comic Sans MS"> (1)為何偵測此毒物? </font></p> |
| − | <p> 通常食用油中是不會含有如此超標的重金屬汞。食用油裡會含有超標的汞</p> | + | <p><font face="Comic Sans MS"> 通常食用油中是不會含有如此超標的重金屬汞。食用油裡會含有超標的汞</font></p> |
| − | <p> 原因是動物攝入甲基汞後囤積於內臟（註1），而餿水油是由內臟油加工</p> | + | <p><font face="Comic Sans MS"> 原因是動物攝入甲基汞後囤積於內臟（註1），而餿水油是由內臟油加工</font></p> |
| − | <p> 製成，但汞不容易被人體代謝掉進而累積在體內造成嚴重的疾病，所以我</p> | + | <p><font face="Comic Sans MS"> 製成，但汞不容易被人體代謝掉進而累積在體內造成嚴重的疾病，所以我</font></p> |
| − | <p> 們才會偵測汞這個重金屬。</p> | + | <p><font face="Comic Sans MS"> 們才會偵測汞這個重金屬。</font></p> |
| − | <p> (2)此毒物的危害 </p> | + | <p><font face="Comic Sans MS"> (2)此毒物的危害 </font></p> |
| − | <p> 甲基汞是已知的神經毒物，會抑制神經細胞的分裂及電離子的移動並干擾</p> | + | <p><font face="Comic Sans MS"> 甲基汞是已知的神經毒物，會抑制神經細胞的分裂及電離子的移動並干擾</font></p> |
| − | <p> 發育中的腦部結構，除此之外，甲基汞還能引起心血管疾病包括心肌梗塞</p> | + | <p><font face="Comic Sans MS"> 發育中的腦部結構，除此之外，甲基汞還能引起心血管疾病包括心肌梗塞</font></p> |
| − | <p> 與缺血性心臟病、高血壓及心律不整（註2）。</p> | + | <p><font face="Comic Sans MS"> 與缺血性心臟病、高血壓及心律不整（註2）。</font></p> |
| − | <p> (3)相關法規 </p> | + | <p><font face="Comic Sans MS"> (3)相關法規 </font></p> |
| − | <p> 食用油脂類衛生標準第二條：重金屬及芥酸之最大容許量：汞0.05 ppm</p> | + | <p><font face="Comic Sans MS"> 食用油脂類衛生標準第二條：重金屬及芥酸之最大容許量：汞0.05 ppm</font></p> |
| − | <p> 食米重金屬限量標準第二條：食米中重金屬含量應符合以下限量：0.05ppm。</p> | + | <p><font face="Comic Sans MS"> 食米重金屬限量標準第二條：食米中重金屬含量應符合以下限量：0.05ppm。</font></p> |
</div> | </div> | ||
<div> | <div> | ||
<h2><font color="#008b8b"> ✡ Circuit Design</font></h2> | <h2><font color="#008b8b"> ✡ Circuit Design</font></h2> | ||
<img src="https://static.igem.org/mediawiki/2015/7/7e/2015hsnu-mercury1.png" height="250" width="400"> | <img src="https://static.igem.org/mediawiki/2015/7/7e/2015hsnu-mercury1.png" height="250" width="400"> | ||
| + | <p><font face="Comic Sans MS"> MerR可以和汞結合然後改變DNA的結構好讓RNA聚合酶方便轉入。</font></p> | ||
| + | <p><font face="Comic Sans MS"> PmerT可以被MerR控制。PmerT步行進行轉錄是因為MerR會改變PmerT的</font></p> | ||
| + | <p><font face="Comic Sans MS"> 形狀。總而言之，只要汞與MerR結合，後續反應就可進行。(註3)(註4)</font></p> | ||
| + | <img src="https://static.igem.org/mediawiki/2015/b/b2/2015hsnu-mercury_2.png" height="250" width="550"> | ||
</div> | </div> | ||
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<h2><font color="#008b8b"> ✡ Reference</font></h2> | <h2><font color="#008b8b"> ✡ Reference</font></h2> | ||
| + | <p><font face="Comic Sans MS"> (註1)Metabolism of mercury, administered as methylmercuric chloride or mercuric chloride, by lactating ruminants.</font></p> | ||
| + | <p><font face="Comic Sans MS"> (註2)台北醫學大學公共衛生學系碩士班碩士論文Graduate Institute.</font></p> | ||
| + | <p><font face="Comic Sans MS"> (註3)Brown, N. L., J. V. Stoyanov, et al. (2003). "The MerR family of transcriptional regulators." FEMS Microbiol Rev 27(2-3): 145-163.</font></p> | ||
| + | <p><font face="Comic Sans MS"> (註4)Park, S. J., J. Wireman, et al. (1992). "Genetic analysis of the Tn21 mer operator-promoter." J Bacteriol 174(7): 2160-2171.</font></p> | ||
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Latest revision as of 12:13, 30 August 2015
Mercury
✡ Introduction
(1)為何偵測此毒物?
通常食用油中是不會含有如此超標的重金屬汞。食用油裡會含有超標的汞
原因是動物攝入甲基汞後囤積於內臟（註1），而餿水油是由內臟油加工
製成，但汞不容易被人體代謝掉進而累積在體內造成嚴重的疾病，所以我
們才會偵測汞這個重金屬。
(2)此毒物的危害
甲基汞是已知的神經毒物，會抑制神經細胞的分裂及電離子的移動並干擾
發育中的腦部結構，除此之外，甲基汞還能引起心血管疾病包括心肌梗塞
與缺血性心臟病、高血壓及心律不整（註2）。
(3)相關法規
食用油脂類衛生標準第二條：重金屬及芥酸之最大容許量：汞0.05 ppm
食米重金屬限量標準第二條：食米中重金屬含量應符合以下限量：0.05ppm。
✡ Circuit Design
MerR可以和汞結合然後改變DNA的結構好讓RNA聚合酶方便轉入。
PmerT可以被MerR控制。PmerT步行進行轉錄是因為MerR會改變PmerT的
形狀。總而言之，只要汞與MerR結合，後續反應就可進行。(註3)(註4)
✡ Result
✡ Reference
(註1)Metabolism of mercury, administered as methylmercuric chloride or mercuric chloride, by lactating ruminants.
(註2)台北醫學大學公共衛生學系碩士班碩士論文Graduate Institute.
(註3)Brown, N. L., J. V. Stoyanov, et al. (2003). "The MerR family of transcriptional regulators." FEMS Microbiol Rev 27(2-3): 145-163.
(註4)Park, S. J., J. Wireman, et al. (1992). "Genetic analysis of the Tn21 mer operator-promoter." J Bacteriol 174(7): 2160-2171.