Difference between revisions of "Team:IIT Madras/Results"

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<h2> Project Results</h2>
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<h1>In-Silico</h1>
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<br><br>
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<h2>Predicting structure of a neutralising protein</h2>
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<p> To achieve our goal of achieving an antimicrobial free environment, it was necessary to inactivate the antimicrobial peptide Alyteserin. When a protein interacts with another protein, its structure is altered. This prevents the protein from performing from it's usual function. This was what we set out to do-design a small peptide that would interact with Alyteserin favourably under specified conditions. We also tried to simulate the interaction between the two peptides using GROMACS, and the results will be discussed later on on this page. First let's analyse the structure of Alyteserin.
  
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<p>Here you can describe the results of your project and your future plans. </p>
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<br></br>
  
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<h5>What should this page contain?</h5>
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<h2>Structural Features of Alyteserin and Naly</h2>
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<li> Clearly and objectively describe the results of your work.</li>
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<li> Future plans for the project </li>
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<li> Considerations for replicating the experiments </li>
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<img height="350px" width="350px" src="https://static.igem.org/mediawiki/2015/7/7a/Alyteserin_structural_feature.png">
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<img height="350px" width="350px" src = "https://static.igem.org/mediawiki/2015/7/72/Naly_structural_feature.png">
  
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<h2>Interactions</h2>
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<div style="text-align:center"><img height="486px" width="633px" src = "https://static.igem.org/mediawiki/2015/a/ad/Aly_naly_interaction.png"></div>
  
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<h4> Project Achievements </h4>
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<h2>GROMACS Simulation</h2>
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<div style="text-align:center"><img height="372px" width="650px" src = "https://static.igem.org/mediawiki/2015/0/05/Igem.gif"></div>
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<p>You can also include a list of bullet points (and links) of the successes and failures you have had over your summer. It is a quick reference page for the judges to see what you achieved during your summer.</p>
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<figcaption>Molecular Dynamics Simulation of the interactions between Alyteserin(red) and NAly(green)</figcaption>
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<li>A list of linked bullet points of the successful results during your project</li>
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<li>A list of linked bullet points of the unsuccessful results during your project. This is about being scientifically honest. If you worked on an area for a long time with no success, tell us so we know where you put your effort.</li>
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<h4>Inspiration</h4>
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<p>See how other teams presented their results.</p>
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<li><a href="https://2014.igem.org/Team:TU_Darmstadt/Results/Pathway">2014 TU Darmstadt </a></li>
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<li><a href="https://2014.igem.org/Team:Imperial/Results">2014 Imperial </a></li>
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<li><a href="https://2014.igem.org/Team:Paris_Bettencourt/Results">2014 Paris Bettencourt </a></li>
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Revision as of 14:56, 15 September 2015

In-Silico



Predicting structure of a neutralising protein

To achieve our goal of achieving an antimicrobial free environment, it was necessary to inactivate the antimicrobial peptide Alyteserin. When a protein interacts with another protein, its structure is altered. This prevents the protein from performing from it's usual function. This was what we set out to do-design a small peptide that would interact with Alyteserin favourably under specified conditions. We also tried to simulate the interaction between the two peptides using GROMACS, and the results will be discussed later on on this page. First let's analyse the structure of Alyteserin.

Structural Features of Alyteserin and Naly



Interactions



GROMACS Simulation

Molecular Dynamics Simulation of the interactions between Alyteserin(red) and NAly(green)