Difference between revisions of "Team:Waterloo/Modeling/Cas9 Dynamics"

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             <h3>Parameters</h3>
 
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                    <p>Fill in this table more, pals!</p>
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<p> Talk about where all the probabilities come from </p>
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                          <th>Value</th>
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                          <th>Units</th>
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                          <th>Description</th>
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                          <td>$k_v$</td>
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                          <td>0.1</td>
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                          <td>min$^{-1}$</td>
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                          <td>Rate at which virions produced by the cell reinfect the nucleus.</td>
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                          <td>$d_{max}$</td>
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                          <td>100/vol</td>
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                          <td>Maximum concentration of viral genomes in the nucleus.</td>
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     <section id="results" title="Results">
 
     <section id="results" title="Results">
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         <h3>Model Validation</h3>
 
         <h3>Model Validation</h3>
 
<p>Include notes on how the model matches reality/our expectations of reality in this section.</p>
 
<p>Include notes on how the model matches reality/our expectations of reality in this section.</p>
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<p>Simulate w/ targets that mismatch to different extents.</p>
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        <h3>Effect of sgRNA Strength</h3>
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<p>Matt visualizations for different sgRNAs.</p>
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<p>Graph of 3 different sgRNA designs of different strengths, show % functional</p>
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        <h3>Importance of Large Deletions</h3>
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<p>Include notes on how the model matches reality/our expectations of reality in this section.</p>
 +
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        <h3>Effect of Cas9 Concentration</h3>
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<p>Include notes on how the model matches reality/our expectations of reality in this section.</p>
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        <h3>Plant Defence by CRISPR/Cas9</h3>
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<p>Show % funcitonal for P6/time over many simulations.</p>
  
 
     </section>
 
     </section>

Revision as of 21:44, 15 September 2015

Modelling Genomic Effects of CRISPR/Cas9

This page contains all our information about the Cas9 Dynamics Model.

Model Formation

Biology of Genomic Cutting, Repair and Deletions by CRISPR/Cas9

Assumptions

Pseudocode

Parameters

Talk about where all the probabilities come from

Results

Model Validation

Include notes on how the model matches reality/our expectations of reality in this section.

Simulate w/ targets that mismatch to different extents.

Effect of sgRNA Strength

Matt visualizations for different sgRNAs.

Graph of 3 different sgRNA designs of different strengths, show % functional

Importance of Large Deletions

Include notes on how the model matches reality/our expectations of reality in this section.

Effect of Cas9 Concentration

Include notes on how the model matches reality/our expectations of reality in this section.

Plant Defence by CRISPR/Cas9

Show % funcitonal for P6/time over many simulations.

Discussion

References

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