Difference between revisions of "Team:Peking"

 
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{{Peking}}
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<h2><center>Welcome to Peking iGEM 2015!</center></h2>
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<!--<p>Your team has been approved and you are ready to start the iGEM season! </p>
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<h4>Before you start: </h4>
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<p> Please read the following pages:</p>
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<li> <a href="https://2015.igem.org/Requirements">Requirements page </a> </li>
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<li> <a href="https://2015.igem.org/Wiki_How-To">Wiki Requirements page</a></li>
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<h4> <center>Project Description</center> </h4>
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<p>Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i>, remains one of the world’s most serious public health problems. Although tuberculosis is curable and the treatment success rate is high, it is still the second most common cause of death from infectious disease (after HIV). Most of the deaths occur in developing countries that are lack of effective identification of those in need of therapy. In 2014 there were 5 million active cases, 1.5 million new cases in China. About 80% cases occurred in rural area, with an enormous amount of delayed or failed diagnosis.</p>
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                            <i class="fa"><img  style="margin-left:0;height:30px;"src="https://static.igem.org/mediawiki/2015/4/45/Peking-Hambergur-1.png" ></i>
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<p>Case detection is currently the rate-limiting step in disease control. A diagnostic tool with high sensitivities and specificities is desired urgently, and it is supposed to be used at the point-of-care (POC) within a clinic or in the community. </p>  
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                        <a class="navbar-brand" href="https://2015.igem.org/Team:Peking">
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                            <img alt="Peking iGEM 2015" src="https://static.igem.org/mediawiki/2015/8/8b/Peking-header-logo-1.png" style="height:55px;margin-top:7px">
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<p>To obviate such problems, Peking iGEM team is developing a novel <!--<i>Mycobacterium tuberculosis</i>-->pathogen detection system that can transform biomarkers of the disease into optical signal or electric signal. Combined with our work in software and hardware development, we believe this new advanced system can be turned out as a powerful tool in disease diagnosis, with high sensitivities and specificities.</p>
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                            <li>
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                                <a href="https://2015.igem.org/Team:Peking/JudgingCriteria">Achievements</a>
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                                <ul class="dropdown">
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                                    <li><a href="https://2015.igem.org/Team:Peking/JudgingCriteria">Judging Criteria</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Parts">Parts</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Collaborations">Collaborations</a>
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                                    </li>
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                                </ul>
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                            </li>
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                            <li>
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                                <a href="https://2015.igem.org/Team:Peking/Design">Project</a>
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                                <ul class="dropdown">
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                                    <li><a href="https://2015.igem.org/Team:Peking/Design">Overview</a>
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                                    </li>
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<li><a href="https://2015.igem.org/Team:Peking/Design/PC_Reporter">Paired<span style="text-transform:lowercase"> d</span>Cas9 Reporter</a>                                   
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</li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Design/Isothermal">Iso-<span style="text-transform:lowercase">t</span>hermal Amplification</a></li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Device">Hardware</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Design/Speculation">Speculation</a>
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                                    </li>
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                                </ul>
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                            </li>
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                            <li>
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                                <a href="https://2015.igem.org/Team:Peking/Modeling">Modeling</a>
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                                <ul class="dropdown">
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                                    <li><a href="https://2015.igem.org/Team:Peking/Modeling">Array Design</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Modeling/Analysis">Analysis Algorithm</a>
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                                    </li>
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                                </ul>
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                            </li>
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                            <li>
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                                <a href="https://2015.igem.org/Team:Peking/Practices">Practices</a>
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                                <ul class="dropdown">
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                                    <li><a href="https://2015.igem.org/Team:Peking/Practices">Overview</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Practices/Background">TB Facts</a>
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                                    </li>
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                                    <li><a  href="https://2015.igem.org/Team:Peking/Practices/Consultation">Consultation and Interview</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Practices/Engagement">Public Engagement</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Practices/Outreach">Ethics and Economics Issues</a>
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                                    </li>
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                                </ul>
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                            </li>
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                            <li>
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                                <a href="https://2015.igem.org/Team:Peking/Team">Lab</a>
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                                <ul>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Team">Team</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Notebook">Notebook</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Attributions">Attributions</a>
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                                    </li>
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                                    <li><a href="https://2015.igem.org/Team:Peking/Safety">Safety</a>
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                                    </li>
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                                </ul>
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<p> <a href="https://2015.igem.org/wiki/index.php?title=Team:Peking&action=edit"> Click here to edit this page! </a></p>
 
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<p>See tips on how to edit your wiki on the <a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation</a> page.</p>
 
  
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      <h3 align="center" style="font-size:24px;color:#00afd1;"> Project Description</h3>
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<p> This year we have created templates for teams to use freely. More information on how to use and edit the templates can be found on the  
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      <div id="project-description" class="title-desc" style="max-width:75%; margin:auto;">
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<a href="https://2015.igem.org/TemplatesforTeams_Code_Documentation">Template Documentation </a> page.</p>  
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        <p>Tuberculosis, caused by <i>Mycobacterium tuberculosis</i>, remains one of the world's most serious public health problems. Although tuberculosis is curable and the treatment success rate is high, it is still the second most common cause of death from infectious disease (after HIV). It causes more than 1.3 million deaths annually, and most of the deaths occur in developing countries that are lack of effective identification of those in need of therapy, with an enormous amount of delayed or failed diagnosis.<br></p>
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        <p><br/>Case detection is currently the rate-limiting step in disease control. The available Nucleic Acid Detection (NAD) Method is sensitive and fast, but does not reach the requirement of specificity and reliability.<br>  
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      <p><br/>To obviate such problems, Peking iGEM team is developing a novel PC Reporters system that can transform biomarkers of the disease into optical signal. Combined with array design and statistical analysis, the presence of <i>Mycobacterium tuberculosis</i> can be easily verified. It can also be easily used in developing areas with designed hardware development. We believe this new advanced system can turn  out as a powerful tool in disease diagnosis, with high specificity and reliability.
  
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            <h3 style="font-size:24px"><span class="accent-color">Awards</span></br>
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                          Best New Composite Part<br/>
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              Best Part Collection
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            </h3>
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            <h3 style="font-size:24px"><span class="accent-color">Poster</span></br>
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            97 - Zone 4 - Hall C</br>
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            <span class="accent-color">Presentation</span></br>
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            9/26/2015 - Room 302 - 11:30 AM
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            </h3>
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            <p class="title-desc" style="margin-top:30px; font-size:22px;font-weight:bold" >Thanks for your attention!</p>
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                <a href="https://2015.igem.org/Team:Peking/Design/PC_Reporter"><img src="https://static.igem.org/mediawiki/2015/3/32/Peking-feature-1.png" style="max-width:180px"></a>
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              </div>
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              <div>
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                <p align="center" style="margin-top:10px"><b>Specificity</b></p>
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                <p style="padding-left:5px;padding-right:5px">A nucleic-acid-based, sequence-specific detection system named "paired dCas9" (PC) reporter was built. Its specificity and sensitivity proved to be enough to detect real MTB genome.</p>
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                <a href="https://2015.igem.org/Team:Peking/Design/PC_Reporter#array"><img src="https://static.igem.org/mediawiki/2015/7/79/Peking-feature-2.png" style="max-width:180px"></a>
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              </div>
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              <div>
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                <p align="center" style="margin-top:10px"><b>Reliability</b></p>
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                <p style="padding-left:5px;padding-right:5px">An array of MTB-specific markers was designed to use information from the entire genome of MTB to improve the reliability of diagnosis. By statistics, we are able to present the readouts in a quantitative way.</i></p>
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                <a href="https://2015.igem.org/Team:Peking/Device"><img src="https://static.igem.org/mediawiki/2015/0/0c/Peking-feature-3.png" style="max-width:180px"></a>
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              </div>
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              <div>
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                <p align="center" style="margin-top:10px"><b>Portability</b></p>
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                <p style="padding-left:5px;padding-right:5px">Noticing that most TB cases occur in developing areas, we built an electronic device that was portable, affordable, and easy to use.</p>
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                <a href="https://2015.igem.org/Team:Peking/Practices"><img src="https://static.igem.org/mediawiki/2015/2/2a/Peking-feature-4.png" style="max-width:180px"></a>
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              </div>
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              <div>
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                <p align="center" style="margin-top:10px"><b>Bench to Bedside</b></p>
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                <p style="padding-left:5px;padding-right:5px">Coming from bedside to bench, we set out to apply our bench achievements back to bedside. With consultation, survey and feedback from clinical practice, we are still working on improving our detection system!</p>
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              <a href="https://2015.igem.org/Team:Peking/Design/PC_Reporter"><i class="fa"><img src="https://static.igem.org/mediawiki/2015/3/32/Peking-feature-1.png" style="max-width:50%"></i></a>
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              <h4>Specificity</h4>
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              <p><br>Designed the novel Paired dCas9 (PC) Reporter system to improve the specificty and tested on <span style="color:#00afd1">real TB genome</span>.</p>
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              <h4>Reliability</h4>
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              <p><br>Combine <span style="color:#00afd1">array design</span> and <span style="color:#00afd1">statistical analysis</span> to verify the presence of <i>Mycobacterium tuberculosis</i>.</p>
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              <a href="https://2015.igem.org/Team:Peking/Device"><i class="fa"><img src="https://static.igem.org/mediawiki/2015/0/0c/Peking-feature-3.png" style="max-width:50%"></i></a>
 +
            </div>
 +
            <div class="service-content">
 +
              <h4>Portability</h4>
 +
              <p>Designed a <span style="color:#00afd1">cheap and portable</span> prototype to be used in developing regions.</p>
 +
            </div>
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              <a href="https://2015.igem.org/Team:Peking/Practices"><i class="fa"><img src="https://static.igem.org/mediawiki/2015/2/2a/Peking-feature-4.png" style="max-width:50%"></i></a>
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            </div>
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            <div class="service-content">
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              <h4>Bench to Bedside</h4>
 +
              <p><br>Come from bedside to bench, and <span style="color:#00afd1">back to bedside</span> again.</p>
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            </div>
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      <!--FOOTER************FOOTER*******************FOOTER***************FOOTER************-->
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        <div class="row footer-widgets" style="padding:0:margin:0">
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          <!-- Start Subscribe & Social Links Widget -->
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                            <h4>Share This<span class="head-line"></span></h4>
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                            </ul>
 +
                        </div>
  
−
<h4>Tips</h4>
+
                        <div class="col-md-12 footer-widget social-widget row">
−
<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
+
                            <h4>Follow Us<span class="head-line"></span></h4>
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<ul>
+
                            <ul class="social-icons" style="padding-top:0:padding-bottom:0;margin-top:0;margin-bottom:0">
−
<li>State your accomplishments! Tell people what you have achieved from the start. </li>
+
                                <li style="padding-top:0:padding-bottom:0;margin-top:0;margin-bottom:0">
−
<li>Be clear about what you are doing and how you plan to do this.</li>
+
                                    <a class="twitter" href="https://twitter.com/iGEM_Peking"><i class="fa"><img src="https://static.igem.org/mediawiki/2015/d/d0/Peking-twitter.png" style="height:20px; margin-top:7px;"></i></a>
−
<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
+
                                </li>
−
<li>Make sure information is easy to find; nothing should be more than 3 clicks away. </li>
+
                                <li style="padding-top:0:padding-bottom:0;margin-top:0;margin-bottom:0">  
−
<li>Avoid using very small fonts and low contrast colors; information should be easy to read. </li>
+
                                    <a class="facebook" href="https://www.facebook.com/pekingigem"><i class="fa"><img src="https://static.igem.org/mediawiki/2015/0/0e/Peking-facebook.png" style="height:20px; margin-top:7px;"></i></a>
−
<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2015.igem.org/Calendar_of_Events">iGEM 2015 calendar</a> </li>
+
                                </li>
−
<li>Have lots of fun! </li>
+
                                <li style="padding-top:0:padding-bottom:0;margin-top:0;margin-bottom:0">
−
</ul>  
+
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 +
                                </li>
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 +
                            </li>
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 +
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                        </ul>
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                        </div>
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                    <div class="col-md-3">
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                        <div class="footer-widget" style="padding:0:margin:0" >
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                        <h4>Contact us<span class="head-line" ></span></h4>
 +
                        <div class="footer-widget contact-widget">
 +
                            <img src="https://static.igem.org/mediawiki/2015/e/e1/Peking-footer-logo-1.png" style="max-height:100px;margin-top:10px;margin-bottom:10px" class="img-responsive" alt="Peking iGEM 2015 Logo" >
 +
                           
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                            <ul  style="font-size:12px;color:#b4b4b4">
 +
                                <li><span>Email:</span> <a href="Mailto:pekingigem@gmail.com&amp;Subject=Hello&amp;Body=Hi, Peking iGEM!"style="color:#b4b4b4">pekingigem@gmail.com</li>
 +
                                <li><span>Website:</span> <a href="2015.igem.org/Team:Peking" style="color:#b4b4b4"> 2015.igem.org/Team:Peking</a></li>
 +
                                <li><span>Address:</span> Peking University, <br>No.5 Yiheyuan Road Haidian District, <br>Beijing, P.R.China 100871</li>
 +
                            </ul>
 +
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                            <p class="text-center">&copy; 2015 Peking iGEM -  All Rights Reserved. Based on <a href="http://getbootstrap.com/"style="color:#b4b4b4">Bootstrap</a> and Margo template.</p>
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−
<h4>Inspiration</h4>
 
−
<p> You can also view other team wikis for inspiration! Here are some examples:</p>
 
−
<ul>
 
−
<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
 
−
<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
 
−
<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
 
−
<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
 
−
<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
 
−
<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
 
−
</ul>
 
  
−
<h4> Uploading pictures and files </h4>
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<p> You can upload your pictures and files to the iGEM 2015 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
+
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When you upload, set the "Destination Filename" to <code>Team:YourOfficialTeamName/NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)</p>
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Latest revision as of 12:42, 17 November 2015

Peking iGEM 2015

Project Description

Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the world's most serious public health problems. Although tuberculosis is curable and the treatment success rate is high, it is still the second most common cause of death from infectious disease (after HIV). It causes more than 1.3 million deaths annually, and most of the deaths occur in developing countries that are lack of effective identification of those in need of therapy, with an enormous amount of delayed or failed diagnosis.


Case detection is currently the rate-limiting step in disease control. The available Nucleic Acid Detection (NAD) Method is sensitive and fast, but does not reach the requirement of specificity and reliability.


To obviate such problems, Peking iGEM team is developing a novel PC Reporters system that can transform biomarkers of the disease into optical signal. Combined with array design and statistical analysis, the presence of Mycobacterium tuberculosis can be easily verified. It can also be easily used in developing areas with designed hardware development. We believe this new advanced system can turn out as a powerful tool in disease diagnosis, with high specificity and reliability.

Awards
Best New Composite Part
Best Part Collection

Poster
97 - Zone 4 - Hall C
Presentation
9/26/2015 - Room 302 - 11:30 AM

Thanks for your attention!

Specificity

A nucleic-acid-based, sequence-specific detection system named "paired dCas9" (PC) reporter was built. Its specificity and sensitivity proved to be enough to detect real MTB genome.

Reliability

An array of MTB-specific markers was designed to use information from the entire genome of MTB to improve the reliability of diagnosis. By statistics, we are able to present the readouts in a quantitative way.

Portability

Noticing that most TB cases occur in developing areas, we built an electronic device that was portable, affordable, and easy to use.

Bench to Bedside

Coming from bedside to bench, we set out to apply our bench achievements back to bedside. With consultation, survey and feedback from clinical practice, we are still working on improving our detection system!